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EC 1.14.13.185 Details
show Brenda entryEC number
1.14.13.185
Accepted name
pikromycin synthase
Reaction
(1) narbomycin + NADPH + H+ + O2 = pikromycin + NADP+ + H2O;;(2) narbomycin + NADPH + H+ + O2 = neopikromycin + NADP+ + H2O;;(3) narbomycin + 2 NADPH + 2 H+ + 2 O2 = novapikromyin + 2 NADP+ + 2 H2O;;(4) 10-deoxymethymycin + NADPH + H+ + O2 = methymycin + NADP+ + H2O;;(5) 10-deoxymethymycin + NADPH + H+ + O2 = neomethymycin + NADP+ + H2O;;(6) 10-deoxymethymycin + 2 NADPH + 2 H+ + 2 O2 = novamethymycin + 2 NADP+ + 2 H2O
Other name(s)
PikC,
CYP107L1
Systematic name
narbomycin,reduced ferredoxin [iron-sulfur] cluster:oxygen oxidoreductase (pikromycin-forming)
Comment
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.
History
created 2014, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
