EC Explorer
[browse EC tree] - [search]
EC 1.14.13.148 Details
show Brenda entryEC number
1.14.13.148
Accepted name
trimethylamine monooxygenase
Reaction
N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O
Other name(s)
flavin-containing monooxygenase 3,
FMO3,
tmm (gene name)
Systematic name
N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming)
Comment
A flavoprotein. The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy [1,4]. The mammalian enzyme is involved in detoxification of trimethylamine. Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome) [2,3].
History
created 2012
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
