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EC 1.14.13.164 Details
show Brenda entryEC number
1.14.13.164
Accepted name
carotenoid isomerooxygenase
Reaction
zeaxanthin + 2 O2 + 2 NADH + 2 H+ = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal + 2 NAD+ + 2 H2O
Other name(s)
ninaB (gene name)
Systematic name
zeaxanthin:oxygen 15,15′-oxidoreductase (bond-cleaving, cis-isomerizing)
Comment
The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary carotenoids in insects. The enzyme accepts different all-trans carotenoids, including β-carotene, α-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.
History
created 2012, deleted 2012
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
