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EC 1.14.13.108 Details
EC number
1.14.13.108
Accepted name
abieta-7,13-diene hydroxylase
Reaction
abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O
Other name(s)
abietadiene hydroxylase (ambiguous)
Systematic name
abieta-7,13-diene,NADPH:oxygen oxidoreductase (18-hydroxylating)
Comment
A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase [1]. Activity is induced by wounding of the plant tissue [2].
History
created 2009, modified 2012, deleted 2018
EC Tree
1.14.13.45 created 1992, deleted 2003