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New Features & Functionalities in 2021

  • Adaption of the structure of the main database resulting in faster loading times and the display of more results for several queries
  • Overall number of active enzymes or organisms described in BRENDA can now be accessed via the TaxTree or the organism search.
  • After a manual curation of the enzyme synonyms the search for enzyme names can now be restricted to genes.
  • Advanced search extended by the search for reactions and due to computing time restricted to BRENDA entries.
  • As the Python2 programming language is not supported anymore, a Python3 module has been implemented for BRENDA`s SOAP interface.
  • In order to address topical subjects or to show data sets in advance the entry page has been expanded by a news section showing up to five news entries in a preview.
  • Enzyme Summary Pages extended by
    • Links to the Transporter Classification Database, TCDB
    • results of the Localization Prediction

New Features & Functionalities in 2020

  • Updates of enzymes refering to COVID-19 and SARS-Cov-2, 3.4.17.23 and 3.4.22.69
  • Revolutionized enzyme summary pages and metabolic pathway maps
  • Revised enzyme proposal tool
  • Calculation of expected taxonomic range extended by information derived from UniProt
  • Gene names marked as such on the enzyme summary pages
  • JSMOL-Viewer for the 3D visualization of protein structures changed to NGL-Viewer

New Features & Functionalities in 2019

  • “Localizaton Prediction” determining the subcellular localizaton of eukaryotic proteins automatically
  • Revised metabolic pathway maps
  • Revised enzyme and ligand summary pages

New Features & Functionalities in 2018

  • More userfriendly structure search for ligands extended with a similarity and isomer search
  • BKMS equipped with a new pathway list
  • Ligand summary pages extended by links to PDB IDs
  • Word Maps providing graphical information on terms and perceptions associated with specific taxonomic terms included (accessible via the start page)
  • Result pages for taxonomic terms (accessible via the Word Maps for taxonomic terms)
  • All manually annotated BRENDA data can be downloaded as a single text file. See section 'Download'.

New Features & Functionalities in 2017

  • 15 metabolic pathways were added to the BRENDA pathway maps.
  • TaxonomyTree extended by BRENDA strains
  • Revision of the organism-specific pathways
  • Revision of the ligand summary pages (according to the result pages in release 2016.2)
  • new tutorials (video and pdf)
  • BKMReact extended by SabioRK reactions
  • Links to DoGSiteScorer (software to detect potential binding pockets) and ProToss (fully automated hydrogen prediction tool for protein-ligand complexes) from the result pages of the 3D Structure Search

New Features & Functionalities in 2016

  • New BRENDA pathway maps are online. Pathways can be selected for an indivdual organism or for a taxonomic group.
  • The BRENDA start page is modified in order to present a new and modern easy-to-use interface.
  • Revision of the result pages for a better user experience:
    • Further acceleration of the display..
    • Sortable columns in all data fields.
    • Hide and show data fields.
    • Improved print functions.

New Features & Functionalities in 2015

  • The BRENDA pathway maps are online. 280 pathways can be displayed. They show ~2000 enzyme-catalyzed reactions. All metabolites and cofactors are linked to the BRENDA data.
  • The new MeSH ontology based on www.nlm.nih.gob/mesh now includes diesease terms and enzyme-disease relations
  • Links to the Biochemical Reaction Kinetics Database SABIO RK in the result pages
  • Acceleration of the result page display
  • The BRENDA Web interface is completely modified and presents a new and modern easy-to-use interface.
  • Word Maps are introduced for 3400 EC classes. The more frequently a word is specifically associated with an enzyme in a literature text, the more prominent it will be presented in the word map. Colors and links are used to provide information of the displayed term.
  • The Enzyme Detector (ED) has been upgraded and equipped with a new algorithm. More data are included in the calculation. These improvements lead to better predictions with a better reliability.
  • The BKM (Biochemical Reactions Aligned) website has been improved. It contains ~22,000 unique enzyme-catalyzed reactions on natural substrates i.e. twice as much as any of the three integrated database (BRENDA, KEGG, MetaCyc).

New Features & Functionalities in 2014

  • The human anatomy atlas CAVEman an ontology for body parts, organs and tissues was included. The terms were linked to the BRENDA tissue terms.
  • BRENDA-Professional provides INChI strings for Ligand structures (http://www.genexplain.com).
  • Strain denominations were added to microorganisms. Enzyme information can be searched and displayed for single strains.

New Features & Functionalities since 2009

In 2009 the content of BRENDA has been substantially increased (see also table above). In addition, many new features & functionalities have been added to the web interface.

The most important recent developments are:

  • ca. 30,000 new literature references since 2009
    The total amount of manually evaluated literature references comprises now more than 120,000 enzyme-specific references.

  • DRENDA (Disease Related ENzyme information DAtabase) - Improvement of the disease-centered textmining approach
    Automated detection of many enzyme-disease relationships by an enhanced disease mining approach which increases the number of literature references in this field by more than tenfold (now more than 400,000 references automatically annotated):
    Search Disease/Diagnostics

  • KENDA (Kinetic ENzyme DAta)
    KENDA is a new supplement to the BRENDA database providing an additional overview on functional kinetic data of enzymes.This additional resource is based on a text-mining resource extracting kinetic values and expressions (KM, Ki, kcat, Vmax etc.)
    Search KENDA

  • BKM-react
    BKM-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA (BRaunschweig ENzyme DAtabase), KEGG, and MetaCyc were matched and integrated by aligning substrates and products.
    Search BKM-react

  • New ligand summary view
    This new site enhances the search for the more than 105,000 enzyme ligands (small molecules) contained in BRENDA. It constitutes a ligand-centric view to the BRENDA data as a complement to the enzyme-centric view of the enzyme summary page (see e.g. EC 1.2.3.4):
    Example for a Ligand Summary View

  • Distribution of Functional Enzyme Parameters
    This new site displays the frequency distribution (histogram) of a functional enzyme parameter such as the number of enzymes for different Km value ranges. It also allows to focus on one of the six EC main classes or the three main taxonomic groups (Archaea, Bacteria, Eukaryota):
    Histograms of Functional Enzyme ParametersFunctional Enzyme Parameters

  • Enhanced view of enzyme 3D structure
    The search site for 3D structure/PDB link now offers the possibility to display the protein sequence motifs in the 3D structure of an enzyme.
    It offers e.g. access to 360,987 active sites, 624,866 metal ion-binding sites and 182,223 nucleotide phosphate-binding regions.
    Example for the enhanced 3D enzyme structure view (marked in yellow)

  • New protein-specific display option for enzymes
    The enzyme summary page was expanded by a protein-specific enzyme search/display option which allows to focus on a single enzyme isoform (protein variant) of the organism of interest. The specification is done via the UniProt Acc.:
    Search for UniProt Accessions

  • Inclusion of MetaCyc pathways
    The Search Pathway form was expanded to also include metabolic pathways MetaCyc (in addition to the KEGG pathways):
    Search Pathway

  • New SBML output option for enzyme-kinetic parameters
    The new site allows the construction of organism-specific metabolic models from BRENDA data using the SBML (Systems Biology Markup Language) format:
    SBML Output Site SBML Logo

  • Improvement of the disease-centered textmining approach
    Automated detection of many enzyme-disease relationships by an enhanced disease mining approach which increases the number of literature references in this field by more than tenfold (now more than 400,000 references automatically annotated):
    Search Disease/Diagnostics