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EC 1.14.13.99 Details
EC number
1.14.13.99
Accepted name
24-hydroxycholesterol 7α-hydroxylase
Reaction
(24R)-cholest-5-ene-3β,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3β,7α,24-triol + NADP+ + H2O
Other name(s)
24-hydroxycholesterol 7α-monooxygenase, CYP39A1, CYP39A1 oxysterol 7α-hydroxylase
Systematic name
(24R)-cholest-5-ene-3β,24-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating)
CAS registry number
288309-90-0
Comment
A heme-thiolate protein (P-450) that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24R)-cholest-5-ene-3β,24-diol as substrate.
History
created 2005, deleted 2016
EC Tree
1.14.13.45 created 1992, deleted 2003