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EC 1.14.13.196 Details
EC number
1.14.13.196
Accepted name
L-ornithine N5-monooxygenase [NAD(P)H]
Reaction
L-ornithine + NAD(P)H + H+ + O2 = N5-hydroxy-L-ornithine + NAD(P)+ + H2O
Other name(s)
SidA (ambiguous)
Systematic name
L-ornithine,NAD(P)H:oxygen oxidoreductase (N5-hydroxylating)
Comment
A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate [3]. cf. EC 1.14.13.195, L-ornithine N5-monooxygenase (NADPH).
History
created 2014
EC Tree
1.14.13.45 created 1992, deleted 2003