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EC 1.14.13.195 Details
show Brenda entryEC number
1.14.13.195
Accepted name
L-ornithine N5-monooxygenase (NADPH)
Reaction
L-ornithine + NADPH + H+ + O2 = N5-hydroxy-L-ornithine + NADP+ + H2O
Other name(s)
CchB,
ornithine hydroxylase,
EtcB,
PvdA,
Af-OMO,
dffA (gene name)
Systematic name
L-ornithine,NADPH:oxygen oxidoreductase (N5-hydroxylating)
Comment
A flavoprotein (FAD). The enzyme is involved in biosynthesis of N5-hydroxy-L-ornithine, N5-formyl-N5-hydroxy-L-ornithine or N5-acetyl-N5-hydroxy-L-ornithine. These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). The enzyme is specific for NADPH. cf. EC 1.14.13.196, L-ornithine N5-monooxygenase [NAD(P)H].
History
created 2014
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
