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EC 1.14.13.154 Details
EC number
1.14.13.154
Accepted name
erythromycin 12-hydroxylase
Reaction
erythromycin D + NADPH + H+ + O2 = erythromycin C + NADP+ + H2O
Other name(s)
EryK
Systematic name
erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating)
Comment
The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B [1].
History
created 2012
EC Tree
1.14.13.45 created 1992, deleted 2003