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EC 1.14.13.242 Details
show Brenda entryEC number
1.14.13.242
Accepted name
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
Reaction
3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2 = 2-(acetamidomethylidene)succinate + NAD(P)+
Other name(s)
MHPCO,
3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing),
methylhydroxypyridinecarboxylate oxidase (misleading),
2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase (incorrect),
methylhydroxypyridine carboxylate dioxygenase (incorrect),
3-hydroxy-3-methylpyridinecarboxylate dioxygenase [incorrect],
3-hydroxy-2-methylpyridinecarboxylate dioxygenase (incorrect)
Systematic name
3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (ring-opening)
CAS registry number
37256-69-2
Comment
Contains FAD. The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have shown that it is a monooxygenase, incorporating only one oxygen atom from molecular oxygen. The second oxygen atom that is incorporated into the product originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation.
History
created 2018 (EC 1.14.12.4 created 1972, incorporated 2018)
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
