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EC 1.14.13.136 Details
show Brenda entryEC number
1.14.13.136
Accepted name
2-hydroxyisoflavanone synthase
Reaction
(1) liquiritigenin + O2 + NADPH + H+ = 2,4′,7-trihydroxyisoflavanone + H2O + NADP+;;(2) (2S)-naringenin + O2 + NADPH + H+ = 2,4′,5,7-tetrahydroxyisoflavanone + H2O + NADP+
Other name(s)
CYP93C,
IFS,
isoflavonoid synthase
Systematic name
liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration)
Comment
Requires cytochrome P-450. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively.
History
created 2011, modified 2013, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
