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EC 1.14.13.104 Details
show Brenda entryEC number
1.14.13.104
Accepted name
(+)-menthofuran synthase
Reaction
(+)-pulegone + NADPH + H+ + O2 = (+)-menthofuran + NADP+ + H2O
Other name(s)
menthofuran synthase,
(+)-pulegone 9-hydroxylase,
(+)-MFS,
cytochrome P450 menthofuran synthase
Systematic name
(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating)
Comment
A heme-thiolate protein (P-450). The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.13.47, (S)-limonene 3-monooxygenase [1].
History
created 2008, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
