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EC 1.14.13.173 Details
show Brenda entryEC number
1.14.13.173
Accepted name
11-oxo-β-amyrin 30-oxidase
Reaction
11-oxo-β-amyrin + 3 O2 + 3 NADPH + 3 H+ = glycyrrhetinate + 3 NADP+ + 4 H2O (overall reaction);;(1a) 11-oxo-β-amyrin + O2 + NADPH + H+ = 30-hydroxy-11-oxo-β-amyrin + NADP+ + H2O;;(1b) 30-hydroxy-11-oxo-β-amyrin + O2 + NADPH + H+ = glycyrrhetaldehyde + NADP+ + 2 H2O;;(1c) glycyrrhetaldehyde + O2 + NADPH + H+ = glycyrrhetinate + NADP+ + H2O
Other name(s)
CYP72A,
CYP72A154
Systematic name
11-oxo-β-amyrin,NADPH:oxygen oxidoreductase (30-hydroxylating)
Comment
A heme-thiolate protein (cytochrome P-450). The enzyme is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice). The enzyme from the plant Medicago truncatula can also hydroxylate β-amyrin.
History
created 2013, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
