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EC 1.14.13.223 Details
EC number
1.14.13.223
Accepted name
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
Reaction
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + NADH + H+ + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + NAD+ + H2O
Other name(s)
sibG (gene name)
Systematic name
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein],NADH:oxygen oxidoreductase (5-hydroxylating)
Comment
A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate.
History
created 2016
EC Tree
1.14.13.45 created 1992, deleted 2003