Reference on EC 3.4.22.B80 - SARS-CoV papain-like protease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Niemeyer, D.; Moesbauer, K.; Klein, E.; Sieberg, A.; Mettelman, R.; Mielech, A.; Dijkman, R.; Baker, S.; Drosten, C.; Mueller, M.
The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
PLoS Pathog.
14
e1007296
2018
Severe acute respiratory syndrome-related coronavirus
Li, S.; Wang, C.; Jou, Y.; Yang, T.; Huang, S.; Wan, L.; Lin, Y.; Lin, C.
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta via ROS/p38 MAPK/STAT3 pathway
Sci. Rep.
6
25754
2016
Severe acute respiratory syndrome-related coronavirus
Malik, A.; Alsenaidy, M.A.
MERS-CoV papain-like protease (PLpro) expression, purification, and spectroscopic/thermodynamic characterization
3 Biotech
7
100
2017
Middle East respiratory syndrome-related coronavirus (JX869059), Middle East respiratory syndrome-related coronavirus
Freitas, B.T.; Durie, I.A.; Murray, J.; Longo, J.E.; Miller, H.C.; Crich, D.; Hogan, R.J.; Tripp, R.A.; Pegan, S.D.
Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
ACS Infect. Dis.
6
2099-2109
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947.3), Severe acute respiratory syndrome coronavirus 2
Wu, C.; Liu, Y.; Yang, Y.; Zhang, P.; Zhong, W.; Wang, Y.; Wang, Q.; Xu, Y.; Li, M.; Li, X.; Zheng, M.; Chen, L.; Li, H.
Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods
Acta Pharm. Sin. B
10
766-788
2020
Severe acute respiratory syndrome coronavirus 2
Lin, M.H.; Moses, D.C.; Hsieh, C.H.; Cheng, S.C.; Chen, Y.H.; Sun, C.Y.; Chou, C.Y.
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
Antiviral Res.
150
155-163
2018
Middle East respiratory syndrome-related coronavirus, Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Procacci, P.; Macchiagodena, M.; Pagliai, M.; Guarnieri, G.; Iannone, F.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Chem. Commun. (Camb.)
56
8854-8856
2020
Severe acute respiratory syndrome coronavirus 2
Li, S.W.; Wang, C.Y.; Jou, Y.J.; Huang, S.H.; Hsiao, L.H.; Wan, L.; Lin, Y.J.; Kung, S.H.; Lin, C.W.
SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6
Int. J. Mol. Sci.
17
678
2016
Severe acute respiratory syndrome-related coronavirus
Clemente, V.; DArcy, P.; Bazzaro, M.
Deubiquitinating enzymes in coronaviruses and possible therapeutic opportunities for COVID-19
Int. J. Mol. Sci.
21
3492
2020
Severe acute respiratory syndrome coronavirus 2
Amin, S.A.; Ghosh, K.; Gayen, S.; Jha, T.
Chemical-informatics approach to COVID-19 drug discovery Monte Carlo based QSAR, virtual screening and molecular docking study of some in-house molecules as papain-like protease (PLpro) inhibitors
J. Biomol. Struct. Dyn.
2020
1-10
2020
Severe acute respiratory syndrome coronavirus 2
Naidoo, D.; Roy, A.; Kar, P.; Mutanda, T.; Anandraj, A.
Cyanobacterial metabolites as promising drug leads against the Mpro and PLpro of SARS-CoV-2 an in silico analysis
J. Biomol. Struct. Dyn.
2020
1-13
2020
Severe acute respiratory syndrome coronavirus 2
Quimque, M.T.J.; Notarte, K.I.R.; Fernandez, R.A.T.; Mendoza, M.A.O.; Liman, R.A.D.; Lim, J.A.K.; Pilapil, L.A.E.; Ong, J.K.H.; Pastrana, A.M.; Khan, A.; Wei, D.Q.; Macabeo, A.P.G.
Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms
J. Biomol. Struct. Dyn.
2020
1-18
2020
Severe acute respiratory syndrome coronavirus 2
Kandeel, M.; Abdelrahman, A.H.M.; Oh-Hashi, K.; Ibrahim, A.; Venugopala, K.N.; Morsy, M.A.; Ibrahim, M.A.A.
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease
J. Biomol. Struct. Dyn.
2020
1-8
2020
Severe acute respiratory syndrome coronavirus 2
Park, J.; Ko, J.; Kim, D.; Kim, Y.; Kwon, H.; Jeong, H.; Kim, C.; Park, K.; Lee, W.; Ryu, Y.
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV
J. Enzyme Inhib. Med. Chem.
31
23-30
2016
Severe acute respiratory syndrome-related coronavirus
Bekes, M.; van der Heden van Noort, G.J.; Ekkebus, R.; Ovaa, H.; Huang, T.T.; Lima, C.D.
Recognition of Lys48-linked di-ubiquitin and deubiquitinating activities of the SARS coronavirus papain-like protease
Mol. Cell
62
572-585
2016
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Shin, D.; Mukherjee, R.; Grewe, D.; Bojkova, D.; Baek, K.; Bhattacharya, A.; Schulz, L.; Widera, M.; Mehdipour, A.R.; Tascher, G.; Geurink, P.P.; Wilhelm, A.; van der Heden van Noort, G.J.; Ovaa, H.; Mueller, S.; Knobeloch, K.P.; Rajalingam, K.; Schulman, B.A.; Cinatl, J.; Hummer, G.; Ciesek, S.; Dik, D.i.k.i.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Nature
587
657-662
2020
Severe acute respiratory syndrome coronavirus 2
Ma-Lauer, Y.; Carbajo-Lozoya, J.; Hein, M.; Mueller, M.; Deng, W.; Lei, J.; Meyer, B.; Kusov, Y.; Von Brunn, B.; Bairad, D.; Huenten, S.; Drosten, C.; Hermeking, H.; Leonhardt, H.; Mann, M.; Hilgenfeld, R.; Von Brunn, A.
P53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
Proc. Natl. Acad. Sci. USA
113
E5192-E5201
2016
Severe acute respiratory syndrome-related coronavirus
-
Reynolds, N.D.; Aceves, N.M.; Liu, J.L.; Compton, J.R.; Leary, D.H.; Freitas, B.T.; Pegan, S.D.; Doctor, K.Z.; Wu, F.Y.; Hu, X.; Legler, P.M.
The SARS-CoV-2 SSHHPS recognized by the papain-like protease
ACS Infect. Dis.
7
1483-1502
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Sivakumar, D.; Stein, M.
Binding of SARS-CoV covalent non-covalent inhibitors to the SARS-CoV-2 papain-like protease and ovarian tumor domain deubiquitinases
Biomolecules
11
802
2021
Severe acute respiratory syndrome coronavirus 2
Shan, H.; Liu, J.; Shen, J.; Dai, J.; Xu, G.; Lu, K.; Han, C.; Wang, Y.; Xu, X.; Tong, Y.; Xiang, H.; Ai, Z.; Zhuang, G.; Hu, J.; Zhang, Z.; Li, Y.; Pan, L.; Tan, L.
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
Cell Chem. Biol.
28
855-865.e9
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Patchett, S.; Lv, Z.; Rut, W.; Bekes, M.; Drag, M.; Olsen, S.K.; Huang, T.T.
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
Cell Rep.
36
109754
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Pitsillou, E.; Liang, J.; Hung, A.; Karagiannis, T.C.
Inhibition of interferon-stimulated gene 15 and lysine 48-linked ubiquitin binding to the SARS-CoV-2 papain-like protease by small molecules In silico studies
Chem. Phys. Lett.
771
138468
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Welker, A.; Kersten, C.; Mller, C.; Madhugiri, R.; Zimmer, C.; Mller, P.; Zimmermann, R.; Hammerschmidt, S.; Maus, H.; Ziebuhr, J.; Sotriffer, C.; Schirmeister, T.
Structure-activity relationships of benzamides and isoindolines designed as SARS-CoV protease inhibitors effective against SARS-CoV-2
ChemMedChem
16
340-354
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Cho, C.C.; Li, S.G.; Lalonde, T.J.; Yang, K.S.; Yu, G.; Qiao, Y.; Xu, S.; Ray Liu, W.
Drug repurposing for the SARS-CoV-2 papain-like protease
ChemMedChem
17
e202100455
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Verma, D.; Mitra, D.; Paul, M.; Chaudhary, P.; Kamboj, A.; Thatoi, H.; Janmeda, P.; Jain, D.; Panneerselvam, P.; Shrivastav, R.; Pant, K.; Das Mohapatra, P.K.
Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/3CLpro molecular docking and simulation studies of three pertinent medicinal plant natural components
Curr. Res. Pharmacol. Drug Discov.
2
100038
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Huynh, T.; Cornell, W.; Luan, B.
In silico exploration of inhibitors for SARS-CoV-2s papain-like protease
Front. Chem.
8
624163
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Xu, Y.; Chen, K.; Pan, J.; Lei, Y.; Zhang, D.; Fang, L.; Tang, J.; Chen, X.; Ma, Y.; Zheng, Y.; Zhang, B.; Zhou, Y.; Zhan, J.; Xu, W.
Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease
Int. J. Biol. Macromol.
188
137-146
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Stasiulewicz, A.; Maksymiuk, A.W.; Nguyen, M.L.; Belza, B.; Sulkowska, J.I.
SARS-CoV-2 papain-like protease potential inhibitors-in silico quantitative assessment
Int. J. Mol. Sci.
22
3957
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Jamalan, M.; Barzegari, E.; Gholami-Borujeni, F.
Structure-based screening to discover new inhibitors for papain-like proteinase of SARS-CoV-2 an in silico study
J. Proteome Res.
20
1015-1026
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Razali, R.; Asis, H.; Budiman, C.
Structure-function characteristics of Sars-cov-2 proteases and their potential inhibitors from microbial sources
Microorganisms
9
2481
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Arya, R.; Prashar, V.; Kumar, M.
Evaluating stability and activity of SARS-CoV-2 PLpro for high-throughput screening of inhibitors
Mol. Biotechnol.
64
1-8
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Bera, K.; Reeda, V.; Babila, P.; Dinesh, D.; Hritz, J.; Karthick, T.
An in silico molecular dynamics simulation study on the inhibitors of SARS-CoV-2 proteases (3CLpro and PLpro) to combat COVID-19
Mol. Simul.
47
1168-1184
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
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Osipiuk, J.; Azizi, S.A.; Dvorkin, S.; Endres, M.; Jedrzejczak, R.; Jones, K.A.; Kang, S.; Kathayat, R.S.; Kim, Y.; Lisnyak, V.G.; Maki, S.L.; Nicolaescu, V.; Taylor, C.A.; Tesar, C.; Zhang, Y.A.; Zhou, Z.; Randall, G.; Michalska, K.; Snyder, S.A.; Dickinson, B.C.; Joachimiak, A.
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
Nat. Commun.
12
743
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Li, L.; Ma, L.; Hu, Y.; Li, X.; Yu, M.; Shang, H.; Zou, Z.
Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease
Phytochemistry
193
112984
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Zhao, Y.; Du, X.; Duan, Y.; Pan, X.; Sun, Y.; You, T.; Han, L.; Jin, Z.; Shang, W.; Yu, J.; Guo, H.; Liu, Q.; Wu, Y.; Peng, C.; Wang, J.; Zhu, C.; Yang, X.; Yang, K.; Lei, Y.; Guddat, L.W.; Xu, W.; Xiao, G.; Sun, L.; Zhang, L.; Rao, Z.; Yang, H.
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
Protein Cell
12
877-888
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Mahmoudvand, S.; Shokri, S.
Interactions between SARS coronavirus 2 papain-like protease and immune system A potential drug target for the treatment of COVID-19
Scand. J. Immunol.
94
e13044
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Weglarz-Tomczak, E.; Tomczak, J.M.; Talma, M.; Burda-Grabowska, M.; Giurg, M.; Brul, S.
Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
Sci. Rep.
11
3640
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Ma, C.; Wang, J.
Validation and invalidation of SARS-CoV-2 papain-like protease inhibitors
ACS Pharmacol. Transl. Sci.
5
102-109
2022
Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome coronavirus 2 BetaCoV/Wuhan/WIV04/2019
Cheng, Y.; Borum, R.; Clark, A.; Jin, Z.; Moore, C.; Fajtova, P.; ODonoghue, A.; Carlin, A.; Jokerst, J.
A dual-color fluorescent probe allows simultaneous imaging of main and papain-like proteases of SARS-CoV-2-infected cells for accurate detection and rapid inhibitor screening
Angew. Chem. Int. Ed. Engl.
61
e202113617
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
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Kankariya, R.A.; Chaudhari, A.B.; Dandi, N.D.
Inhibitory efficacy of 2, 4-diacetylphloroglucinol against SARS-COV-2 proteins in silico study
Biologia
2022
1-14
2022
severe acute respiratory syndrome coronavirus (P0C6U8)
Sencanski, M.; Perovic, V.; Milicevic, J.; Todorovic, T.; Prodanovic, R.; Veljkovic, V.; Paessler, S.; Glisic, S.
Identification of SARS-CoV-2 papain-like protease (PLpro) inhibitors using combined computational approach
ChemistryOpen
11
e202100248
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Tian, X.; Zhao, Q.; Chen, X.; Peng, Z.; Tan, X.; Wang, Q.; Chen, L.; Yang, Y.
Discovery of novel and highly potent inhibitors of SARS CoV-2 papain-like protease through structure-based pharmacophore modeling, virtual screening, molecular docking, molecular dynamics simulations, and biological evaluation
Front. Pharmacol.
13
817715
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Zhang, L.C.; Zhao, H.L.; Liu, J.; He, L.; Yu, R.L.; Kang, C.M.
Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening
Future Med. Chem.
14
393-405
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Swargiary, A.; Mahmud, S.; Saleh, M.
Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2 an in silico approach to combat COVID-19
J. Biomol. Struct. Dyn.
40
2067-2081
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Bhattacharya, K.; Bordoloi, R.; Chanu, N.R.; Kalita, R.; Sahariah, B.J.; Bhattacharjee, A.
In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2
J. Gen. Eng. Biotechnol.
20
43
2022
Severe acute respiratory syndrome coronavirus 2 (P0C6U8)
Ghosh, Ak.; Takayama, J.; Aubin, Y.; Ratia, K.; Chaudhuri, R.; Baez, Y.; Sleeman, K.; Coughlin, M.; Nichols, D.B.; Mulhearn, D.C.; Prabhakar, B.S.; Baker, S.C.; Johnson, M.E.; Mesecar, A.D.
Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease
J. Med. Chem.
52
5228-5240
2009
severe acute respiratory syndrome coronavirus
Ghosh, A.K.; Takayama, J.; Rao, K.V.; Ratia, K.; Chaudhuri, R.; Mulhearn, D.C.; Lee, H.; Nichols, D.B.; Baliji, S.; Baker, S.C.; Johnson, M.E.; Mesecar, A.D.
Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors design, synthesis, protein-ligand X-ray structure and biological evaluation
J. Med. Chem.
53
4968-4979
2010
severe acute respiratory syndrome coronavirus
Baez-Santos, Y.M.; Barraza, S.J.; Wilson, M.W.; Agius, M.P.; Mielech, A.M.; Davis, N.M.; Baker, S.C.; Larsen, S.D.; Mesecar, A.D.
X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases
J. Med. Chem.
57
2393-412
2014
severe acute respiratory syndrome coronavirus
Liu, N.; Zhang, Y.; Lei, Y.; Wang, R.; Zhan, M.; Liu, J.; An, Y.; Zhou, Y.; Zhan, J.; Yin, F.; Li, Z.
Design and evaluation of a novel peptide-drug conjugate covalently targeting SARS-CoV-2 papain-like protease
J. Med. Chem.
65
876-884
2022
severe acute respiratory syndrome coronavirus, Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Amin, S.; Ghosh, K.; Singh, S.; Qureshi, I.; Jha, T.; Gayen, S.
Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery
Mol. Divers.
26
215-228
2022
Severe acute respiratory syndrome coronavirus 2
Rao, P.; Patel, R.; Shukla, A.; Parmar, P.; Rawal, R.; Saraf, M.; Goswami, D.
Identifying structural-functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation
Mol. Divers.
26
309-329
2022
severe acute respiratory syndrome coronavirus (P0C6U8), Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Suleimen, Y.M.; Jose, R.A.; Suleimen, R.N.; Arenz, C.; Ishmuratova, M.; Toppet, S.; Dehaen, W.; Alsfouk, A.A.; Elkaeed, E.B.; Eissa, I.H.; Metwaly, A.M.
Isolation and in silico anti-SARS-CoV-2 papain-like protease potentialities of two rare 2-phenoxychromone derivatives from Artemisia spp
Molecules
27
1216
2022
severe acute respiratory syndrome coronavirus (P0C6U8)
Phong, N.V.; Trang, N.M.; Quyen, C.T.; Anh, H.L.T.; Vinh, L.B.
SARS-CoV-2 main protease and papain-like protease inhibition by abietane-type diterpenes isolated from the branches of Glyptostrobus pensilis using molecular docking studies
Nat. Prod. Res.
2022
1-8
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Ratia, K.; Pegan, S.; Takayama, J.; Sleeman, K.; Coughlin, M.; Baliji, S.; Chaudhuri, R.; Fu, W.; Prabhakar, B.S.; Johnson, M.E.; Baker, S.C.; Ghosh, A.K.; Mesecar, A.D.
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Proc. Natl. Acad. Sci. USA
105
16119-16124
2008
severe acute respiratory syndrome coronavirus
Lewis, D.S.M.; Ho, J.; Wills, S.; Kawall, A.; Sharma, A.; Chavada, K.; Ebert, M.C.C.J.C.; Evoli, S.; Singh, A.; Rayalam, S.; Mody, V.; Taval, S.
Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro
Sci. Rep.
12
2145
2022
Severe acute respiratory syndrome coronavirus 2
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