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Literature summary for 3.4.22.B80 extracted from

  • Reynolds, N.D.; Aceves, N.M.; Liu, J.L.; Compton, J.R.; Leary, D.H.; Freitas, B.T.; Pegan, S.D.; Doctor, K.Z.; Wu, F.Y.; Hu, X.; Legler, P.M.
    The SARS-CoV-2 SSHHPS recognized by the papain-like protease (2021), ACS Infect. Dis., 7, 1483-1502 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B80

Inhibitors

Inhibitors Comment Organism Structure
Zn2+
-
 Severe acute respiratory syndrome coronavirus 2

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FOXP3 + H2O cleavage site: LLIALRGG-/-KI Severe acute respiratory syndrome coronavirus 2 ?
-
 ?
IRF-3 + H2O cleavage site: VLSCLGGG-/-LALWR Severe acute respiratory syndrome coronavirus 2 ?
-
 ?
additional information sequences cleaved by the SARS-CoV-2 papain-like protease (PLpro) are identified in vitro within human MYH7 and MYH6 (two cardiac myosins linked to several cardiomyopathies), FOXP3 (an X-linked Treg cell transcription factor), ErbB4 (HER4), and vitamin-K-dependent plasma protein S (PROS1), an anticoagulation protein that prevents blood clots Severe acute respiratory syndrome coronavirus 2 ?
-
-
MYH6 + H2O cleavage site: IALKGG-/-K Severe acute respiratory syndrome coronavirus 2 ?
-
 ?
MYH7 + H2O cleavage site: RDLRGG-/-A Severe acute respiratory syndrome coronavirus 2 ?
-
 ?
PROS1 + H2O cleavage site: LTEILNGG-/-V Severe acute respiratory syndrome coronavirus 2 ?
-
 ?
ULK1 + H2O cleavage site: RKLSLGGG-/-RPY Severe acute respiratory syndrome coronavirus 2 ?
-
 ?

Synonyms

Synonyms Comment Organism
PLpro
-
 Severe acute respiratory syndrome coronavirus 2
SARS-CoV-2 papain-like protease
-
 Severe acute respiratory syndrome coronavirus 2