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Literature summary for 3.4.22.B80 extracted from

  • Cho, C.C.; Li, S.G.; Lalonde, T.J.; Yang, K.S.; Yu, G.; Qiao, Y.; Xu, S.; Ray Liu, W.
    Drug repurposing for the SARS-CoV-2 papain-like protease (2021), ChemMedChem, 17, e202100455 .
    View publication on PubMed
Search for more literature for 3.4.22.B80

Inhibitors

Inhibitors Comment Organism Structure
(9E)-9-prop-2-enoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile i.e. DUB-IN-3 Severe acute respiratory syndrome coronavirus 2
2-(pyridin-3-yl)naphthalo(-2,3-d)oxazole-4,9-dione i.e. SJB3-019 A Severe acute respiratory syndrome coronavirus 2
2-phenylbenzo[f][1,3]benzoxazole-4,9-dione i.e. SJB2-043 Severe acute respiratory syndrome coronavirus 2
4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
-
 Severe acute respiratory syndrome coronavirus 2
5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide i.e. GRL0617 Severe acute respiratory syndrome coronavirus 2
N-[3-(diethylamino)propyl]-7-oxo-7H-dibenzo[de,g]quinoline-4-carboxamide i.e. PR-619; i.e.S130 Severe acute respiratory syndrome coronavirus 2

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-LRGG-7-amido-4-methylcoumarin + H2O
-
 Severe acute respiratory syndrome coronavirus 2 benzyloxycarbonyl-LRGG + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
PLpro
-
 Severe acute respiratory syndrome coronavirus 2
SARS-CoV-2 papain-like protease
-
 Severe acute respiratory syndrome coronavirus 2

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00056
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
0.00137
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
0.0061
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 N-[3-(diethylamino)propyl]-7-oxo-7H-dibenzo[de,g]quinoline-4-carboxamide
0.00642
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
0.00815
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
0.0125
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 (9E)-9-prop-2-enoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
0.035
-
 pH 8.5, 37°C Severe acute respiratory syndrome coronavirus 2 N-[3-(diethylamino)propyl]-7-oxo-7H-dibenzo[de,g]quinoline-4-carboxamide

General Information

General Information Comment Organism
physiological function Papain-like protease (PLpro) is a cysteine protease with deubiquitination and deISGylation activities, and is essential for SARS-CoV-2 replication and pathogenesis Severe acute respiratory syndrome coronavirus 2