Cheng, Y.; Borum, R.; Clark, A.; Jin, Z.; Moore, C.; Fajtova, P.; ODonoghue, A.; Carlin, A.; Jokerst, J.
A dual-color fluorescent probe allows simultaneous imaging of main and papain-like proteases of SARS-CoV-2-infected cells for accurate detection and rapid inhibitor screening (2022), Angew. Chem. Int. Ed. Engl., 61, e202113617 .
No PubMed abstract available
Application
Application |
Comment |
Organism |
analysis |
development of a dual-color probe for the simultaneous detection of Mpro and PLpro by FRET in vitro and in cells. The probe produces fluorescence from both the Cy3 and Cy5 fluorophores that are cleaved by Mpro and PLpro |
Severe acute respiratory syndrome coronavirus 2 |
Organism
Organism |
UniProt |
Comment |
Textmining |
Severe acute respiratory syndrome coronavirus 2 |
P0DTD1 |
replicase polyprotein 1ab |
- |