Literature summary for 3.4.22.B80 extracted from

Li, S.W.; Wang, C.Y.; Jou, Y.J.; Huang, S.H.; Hsiao, L.H.; Wan, L.; Lin, Y.J.; Kung, S.H.; Lin, C.W.
SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6 (2016), Int. J. Mol. Sci., 17, 678 .

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Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome-related coronavirus	-	human, i.e. SARS-CoV	-

Synonyms

Synonyms	Comment	Organism
SARS coronavirus papain-like protease	-	Severe acute respiratory syndrome-related coronavirus
SARS-CoV PLpro	-	Severe acute respiratory syndrome-related coronavirus

General Information

General Information	Comment	Organism
metabolism	the enzyme significantly inhibits imiquimod-induced cytokine production through suppressing the activation of transcription factors IRF-3, NF-kappaB and AP-1. Western blot analysis with anti-Lys48 and anti-Lys63 ubiquitin antibodies indicates the SARS-CoV PLPro removes Lys63-linked ubiquitin chains of TRAF3 and TRAF6, but not Lys48-linked ubiquitin chains in un-treated and treated cells. The decrease in the activated state of TRAF3 and TRAF6 correlates with the inactivation of TBK1 in response to imiquimod by papain-like protease (PLPro). The results reveal that the antagonism of SARS-CoV PLPro on TLR7-mediated innate immunity is associated with the negative regulation of TRAF3/6-TBK1-IRF3/NF-kappaB/AP1 signals	Severe acute respiratory syndrome-related coronavirus

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Release 2023.1 (January 2023)