Literature summary for 3.4.22.B80 extracted from

Patchett, S.; Lv, Z.; Rut, W.; Bekes, M.; Drag, M.; Olsen, S.K.; Huang, T.T.
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease (2021), Cell Rep., 36, 109754 .

Search for more literature for 3.4.22.B80

Protein Variants

Protein Variants	Comment	Organism
K232Q	mutation alters activity on ubiquitin	Severe acute respiratory syndrome coronavirus 2

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome coronavirus 2	P0DTD1	SARS-CoV-2	-

Synonyms

Synonyms	Comment	Organism
PLpro	-	Severe acute respiratory syndrome coronavirus 2
SARS-CoV-2 papain-like protease	-	Severe acute respiratory syndrome coronavirus 2

General Information

General Information	Comment	Organism
drug target	the enzyme is a target for antiviral drug development	Severe acute respiratory syndrome coronavirus 2
physiological function	the enzyme is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (Ubl) conjugates. The S1 sensor region within the S1 Ub-binding site of PLpro is a potential hotspot of variability that could alter host antiviral immune responses to newly emerging SARS-CoV-2 lineages	Severe acute respiratory syndrome coronavirus 2

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)