Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.B80 extracted from

  • Ma-Lauer, Y.; Carbajo-Lozoya, J.; Hein, M.; Mueller, M.; Deng, W.; Lei, J.; Meyer, B.; Kusov, Y.; Von Brunn, B.; Bairad, D.; Huenten, S.; Drosten, C.; Hermeking, H.; Leonhardt, H.; Mann, M.; Hilgenfeld, R.; Von Brunn, A.
    P53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1 (2016), Proc. Natl. Acad. Sci. USA, 113, E5192-E5201 .
No PubMed abstract available
Search for more literature for 3.4.22.B80

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus
-
 human, i.e. SARS-CoV
-

Purification (Commentary)

Purification (Comment) Organism
-
 Severe acute respiratory syndrome-related coronavirus

Synonyms

Synonyms Comment Organism
SARS-CoV PLpro
-
 Severe acute respiratory syndrome-related coronavirus

General Information

General Information Comment Organism
physiological function the papain-like protease physically interacts with and stabilizes E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCHY1), and thus triggers degradation of endogenous host antiviral factor p53,which impairs viral replication Severe acute respiratory syndrome-related coronavirus