2.4.2.60: cysteine-dependent adenosine diphosphate thiazole synthase
This is an abbreviated version!
For detailed information about cysteine-dependent adenosine diphosphate thiazole synthase, go to the full flat file.
Reaction
Synonyms
ADP-thiazole synthase, CyPBP37, NCU06110, Thi-4, THI1, Thi4
ECTree
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Engineering
Engineering on EC 2.4.2.60 - cysteine-dependent adenosine diphosphate thiazole synthase
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A140V
E222G
complete loss of activity, leading to disruption of the thiamine biosynthetic route
G77V
complete loss of activity, leading to disruption of the thiamine biosynthetic route
H167F
complete loss of activity, leading to disruption of the thiamine biosynthetic route
C204A
C205S
the mutant is catalytic in the presence of exogenous sulfide
H200N
H237N
the mutant only catalyzes the conversion of ADP-ribose to ADP-ribulose
complete loss of activity, leading to disruption of the thiamine biosynthetic route
A140V
mutant contains more sulfur-containing cysteines than wild-type, and its conformational stability is affected
mutant catalyzes the release of the nicotinamide moiety from NAD to produce ADP-ribose, which is further converted to ADP-ribulose. In the presence of glycine, mutant catalyzes the formation of an advanced intermediate
mutant catalyzes the release of the nicotinamide moiety from NAD to produce ADP-ribose, which is further converted to ADP-ribulose. In the presence of glycine, mutant catalyzes the formation of an advanced intermediate