2.4.2.60: cysteine-dependent adenosine diphosphate thiazole synthase
This is an abbreviated version!
For detailed information about cysteine-dependent adenosine diphosphate thiazole synthase, go to the full flat file.
Reaction
Synonyms
ADP-thiazole synthase, CyPBP37, NCU06110, Thi-4, THI1, Thi4
ECTree
2.4.2.60 cysteine-dependent adenosine diphosphate thiazole synthaseAdvanced search results
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Substrates Products on EC 2.4.2.60 - cysteine-dependent adenosine diphosphate thiazole synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
-
-
-
-
?
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
-
-
-
-
?
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
-
-
-
?
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
-
-
-
-
?
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
-
-
-
?
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
-
-
-
-
?
additional information
?
-
Thi4 is a suicidal enzyme undergoing only a single turnover
-
-
?
additional information
?
-
mechanism starts with cleavage of the N-glycosyl bond of NAD followed by ring opening, tautomerization and loss of water. Reaction continues with imine formation, tautomerization, sulfide addition and cyclization. Elimination of two water molecules followed by a tautomerization completes the formation of the thiazole moiety
-
-
?
additional information
?
-
mechanism starts with cleavage of the N-glycosyl bond of NAD followed by ring opening, tautomerization and loss of water. Reaction continues with imine formation, tautomerization, sulfide addition and cyclization. Elimination of two water molecules followed by a tautomerization completes the formation of the thiazole moiety
-
-
?
