Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
C204A | partially active mutant | Saccharomyces cerevisiae |
H200N | partially active mutant | Saccharomyces cerevisiae |
R301Q | inactive | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | iron-dependent sulfide transfer reaction from the protein to a reaction intermediate | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | Thi4 is a suicidal enzyme undergoing only a single turnover | ? | - |
? | |
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine | Saccharomyces cerevisiae | - |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P32318 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Thi4 is a suicidal enzyme undergoing only a single turnover | Saccharomyces cerevisiae | ? | - |
? | |
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine | - |
Saccharomyces cerevisiae | nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Thi4 | - |
Saccharomyces cerevisiae |