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Information on EC 2.4.2.60 - cysteine-dependent adenosine diphosphate thiazole synthase

for references in articles please use BRENDA:EC2.4.2.60
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EC Tree
IUBMB Comments
This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo . The homologous enzyme in archaea (EC 2.4.2.59, sulfide-dependent adenosine diphosphate thiazole synthase) uses sulfide as sulfur donor.
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The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
Synonyms
cypbp37, thi-4, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
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PATHWAY SOURCE
PATHWAYS
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