1.14.14.87: 2-hydroxyisoflavanone synthase

This is an abbreviated version!
For detailed information about 2-hydroxyisoflavanone synthase, go to the full flat file.

Reaction

Synonyms

2-HIS, 2-hydroxyisoflavanone synthase, 2-hydroxyisoflavanone synthase 1, 2HI synthase, CYP93C, Cyp93C1, CYP93C18, CYP93C2, Cyp93C20, CYT93C, EC 1.14.13.136, EC 1.14.13.86, GmIFS, GmIFS1, IFS, IFS1, IFS2, IFS2-12, isoflavone synthase, isoflavone synthase 2

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.87 2-hydroxyisoflavanone synthase

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Results	in table
1	Activating Compound
19	AA Sequence
1	Application
9	Cloned(Commentary)
6	Cofactor
3	Expression
10	General Information
5	Inhibitors
4	KM Value [mM]
8	Localization
1	Metals/Ions
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
22	Organism
5	Pathway
2	pH Optimum
2	pH Range
9	Protein Variants
2	Reaction
21	Reference
7	Source Tissue
20	Substrates and Products (Substrate)
2	Subunits
37	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.14.87 - 2-hydroxyisoflavanone synthase

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SYSTEMATIC NAME

IUBMB Comments

liquiritigenin, [reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (hydroxylating, aryl migration)

A cytochrome P-450 (heme thiolate) protein found in plants. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively.