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1.14.14.87: 2-hydroxyisoflavanone synthase

This is an abbreviated version!
For detailed information about 2-hydroxyisoflavanone synthase, go to the full flat file.

Word Map on EC 1.14.14.87

Reaction

(2S)-naringenin
+
O2
 +
[reduced NADPH-hemoprotein reductase]
=
2,4',5,7-tetrahydroxyisoflavanone
 +
H2O
 +
[oxidized NADPH-hemoprotein reductase]

Synonyms

2-HIS, 2-hydroxyisoflavanone synthase, 2-hydroxyisoflavanone synthase 1, 2HI synthase, CYP93C, Cyp93C1, CYP93C18, CYP93C2, Cyp93C20, CYT93C, EC 1.14.13.136, EC 1.14.13.86, GmIFS, GmIFS1, IFS, IFS1, IFS2, IFS2-12, isoflavone synthase, isoflavone synthase 2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.87 2-hydroxyisoflavanone synthase

Expression

Expression on EC 1.14.14.87 - 2-hydroxyisoflavanone synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
gene ifs1, recombinant coexpression of Arabidopsis thaliana transcription factor, AtMYB12, and Glycine max isoflavone synthase, GmIFS1, genes in Nicotiana benthamiana leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotective activity
increased expression upon elicitation
the R2R3-type MYB transcription factor GmMYB29 is located in the nucleus and activates the IFS2 (isoflavone synthase 2) gene promoter. Overexpression and RNAi-mediated silencing of GmMYB29 in soybean hairy roots results in increased and decreased isoflavone content, respectively. 11 Natural GmMYB29 polymorphisms are significantly associated with isoflavone contents, and regulation of GmMYB29 expression partially contributes to a phenotypic variation observed after inhibition of GmMYB29