EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
cerebellum |
- |
740503 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
cerebellum |
- |
654196 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
cerebellum |
post-mortem semi-quantitative expression analysis in brain of control individuals and Parkinson disease patients, SPR expression is increased in Parkinson patients, but not in the other genes involved in the tetrahydrobiopterin biosynthesis, overview |
685875 |
1.1.1.27 | L-lactate dehydrogenase |
cerebellum |
- |
685322 |
1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase |
cerebellum |
- |
722472 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
cerebellum |
6% mRNA expression of Rdh5 compared to liver |
690797 |
1.1.1.330 | very-long-chain 3-oxoacyl-CoA reductase |
cerebellum |
- |
721750 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
cerebellum |
- |
688956 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
cerebellum |
high expression |
685803 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
cerebellum |
- |
712993 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
cerebellum |
and longissimus dorsi muscle, similar expression pattern that is at a low level at birth and increasing with aging to the highest level at postnatal day 8 in longissinus doris muscle and postnatal day 14 in cerebrum. Weaning decreases the expression level of the GPD1 gene |
712993 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
cerebellum |
- |
654196 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
cerebellum |
- |
671327, 697470 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
cerebellum |
white matter |
688464 |
1.11.1.9 | glutathione peroxidase |
cerebellum |
- |
677215, 686868 |
1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |
cerebellum |
abundantly expressed in neurons of |
658410 |
1.13.11.34 | arachidonate 5-lipoxygenase |
cerebellum |
- |
684399 |
1.13.11.34 | arachidonate 5-lipoxygenase |
cerebellum |
high level of expression |
439477 |
1.13.11.34 | arachidonate 5-lipoxygenase |
cerebellum |
highest expresion of the enzyme in brain |
-, 689167 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
cerebellum |
- |
743037 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
cerebellum |
- |
700466, 726330 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
cerebellum |
of the fetus |
695432 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
cerebellum |
high expression in adult mouse brain |
764386 |
1.14.13.29 | 4-nitrophenol 2-monooxygenase |
cerebellum |
- |
673929 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
cerebellum |
- |
-, 440194, 440196, 440197, 440198, 440199, 440202, 440203, 440211, 440220, 440232, 440236, 686293, 765779 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
cerebellum |
nNOS |
687358 |
1.14.14.154 | sterol 14alpha-demethylase |
cerebellum |
- |
673147 |
1.14.14.19 | steroid 17alpha-monooxygenase |
cerebellum |
- |
-, 715984 |
1.14.14.25 | cholesterol 24-hydroxylase |
cerebellum |
cerebellar interneurons and Purkinje cells |
687987 |
1.14.15.4 | steroid 11beta-monooxygenase |
cerebellum |
cerebellar granule layer |
688009 |
1.14.16.2 | tyrosine 3-monooxygenase |
cerebellum |
ataxic and control, high enzyme expression level in ataxic mice, dramatic difference in cerebellar tyrosine hydroxylase immunoreactivity between mutant pogo, wild-type, and mutant p35-/- and p39-/- mice, overview |
688960 |
1.14.16.5 | alkylglycerol monooxygenase |
cerebellum |
- |
688220 |
1.14.17.1 | dopamine beta-monooxygenase |
cerebellum |
- |
727633 |
1.14.19.3 | acyl-CoA 6-desaturase |
cerebellum |
neurons |
438421 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
cerebellum |
- |
673515, 686417, 698086 |
1.17.1.4 | xanthine dehydrogenase |
cerebellum |
- |
644557, 644558 |
1.17.1.4 | xanthine dehydrogenase |
cerebellum |
high rate of dehydrogenase activity |
644557, 644558 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
cerebellum |
- |
673870, 675552, 676088, 762740 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
cerebellum |
- |
685334 |
1.2.1.25 | branched-chain alpha-keto acid dehydrogenase system |
cerebellum |
within the cerebellum, there is punctate labelling in the processes of cells within the Purkinje cell layer, most likely to be Bergmann astrocytes. The Purkinje cells themselves are unlabelled (12/18 brains examined) or weakly immunopositive. Within the granule cell layer, rosette like structures (glomeruli) are immunopositive. Within the deep cerebellar nuclei, there is strong granular immunopositivity in small glial cells in contrast to the largely immunonegative neurons |
763513 |
1.2.1.48 | long-chain-aldehyde dehydrogenase |
cerebellum |
- |
725656 |
1.2.3.1 | aldehyde oxidase |
cerebellum |
- |
390422 |
1.2.4.2 | oxoglutarate dehydrogenase (succinyl-transferring) |
cerebellum |
- |
699606 |
1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) |
cerebellum |
- |
725082 |
1.21.1.1 | iodotyrosine deiodinase |
cerebellum |
- |
701712 |
1.21.99.3 | thyroxine 5-deiodinase |
cerebellum |
isozyme type III |
-, 644807 |
1.21.99.3 | thyroxine 5-deiodinase |
cerebellum |
Purkinje cells |
-, 644807 |
1.3.1.24 | biliverdin reductase |
cerebellum |
- |
711794, 724423, 725769 |
1.3.3.6 | acyl-CoA oxidase |
cerebellum |
- |
712822 |
1.3.5.1 | succinate dehydrogenase |
cerebellum |
significant decrease in activity following aluminium exposure. Post-treatment with centrophenoxine restores the altered enzyme activity |
675951 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
cerebellum |
low enzyme level |
713150 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
cerebellum |
low level both of expression and activity |
713150 |
1.4.3.1 | D-aspartate oxidase |
cerebellum |
- |
742426, 743140 |
1.4.3.3 | D-amino-acid oxidase |
cerebellum |
- |
679652, 688608, 690048, 696139, 699164, 723920, 723921, 743131, 763218 |
1.4.3.3 | D-amino-acid oxidase |
cerebellum |
Bermann glia |
699644 |
1.4.3.3 | D-amino-acid oxidase |
cerebellum |
higher expression of DAO mRNA in the cerebellum, but lower expression of DAO protein in the cerebellum compared to the other brain regions studied. DAO mRNA levels are positively correlated with age <2 years in the cerebellum and amygdala |
763093 |
1.4.3.5 | pyridoxal 5'-phosphate synthase |
cerebellum |
13.3% of the activity in liver detected in left cerebellum, 25.0% of the activity in liver detected in the right cerebellum |
655483 |
1.5.1.21 | 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) |
cerebellum |
- |
741580 |
1.5.1.25 | thiomorpholine-carboxylate dehydrogenase |
cerebellum |
- |
741580 |
1.5.3.16 | spermine oxidase |
cerebellum |
splice variant mSMO |
692157 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
cerebellum |
- |
658473 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
cerebellum |
the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls |
660005 |
1.6.99.1 | NADPH dehydrogenase |
cerebellum |
- |
673464 |
1.8.3.2 | thiol oxidase |
cerebellum |
- |
659578 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
cerebellum |
- |
686598 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
cerebellum |
high MsrA expression level |
668581 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
cerebellum |
- |
657722, 711940 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
cerebellum |
isozyme MsrB2 |
669008 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
cerebellum |
- |
394027 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
cerebellum |
myelin sheet |
394026 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
cerebellum |
within the myelin sheets |
394026 |
2.1.1.10 | homocysteine S-methyltransferase |
cerebellum |
low expression level |
756095 |
2.1.1.2 | guanidinoacetate N-methyltransferase |
cerebellum |
- |
687352 |
2.1.1.203 | tRNA (cytosine34-C5)-methyltransferase |
cerebellum |
NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum |
718539 |
2.1.1.6 | catechol O-methyltransferase |
cerebellum |
- |
685455 |
2.3.1.108 | alpha-tubulin N-acetyltransferase |
cerebellum |
- |
736795 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
cerebellum |
moderate expression |
701623 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
cerebellum |
- |
755989 |
2.3.1.24 | sphingosine N-acyltransferase |
cerebellum |
- |
-, 754045 |
2.3.1.286 | protein acetyllysine N-acetyltransferase |
cerebellum |
- |
739439 |
2.3.1.297 | very-long-chain ceramide synthase |
cerebellum |
- |
-, 754045 |
2.3.1.299 | sphingoid base N-stearoyltransferase |
cerebellum |
- |
754045 |
2.3.1.42 | glycerone-phosphate O-acyltransferase |
cerebellum |
- |
658362 |
2.3.1.50 | serine C-palmitoyltransferase |
cerebellum |
granule cells, neuronal cells |
487169 |
2.3.1.50 | serine C-palmitoyltransferase |
cerebellum |
Purkinje cells |
487177 |
2.3.1.6 | choline O-acetyltransferase |
cerebellum |
- |
756641 |
2.3.1.6 | choline O-acetyltransferase |
cerebellum |
33% of activity membrane associated |
660007 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
cerebellum |
- |
-, 736082, 758981 |
2.3.2.2 | gamma-glutamyltransferase |
cerebellum |
- |
487930 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
cerebellum |
- |
735738 |
2.3.3.1 | citrate (Si)-synthase |
cerebellum |
- |
720554 |
2.4.1.149 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase |
cerebellum |
very weak expression of beta3GnT7 |
-, 638581 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
cerebellum |
IGnT is highly expressed in adult cerebellum |
638567 |
2.4.1.206 | lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
cerebellum |
- |
-, 638234, 638235, 721936 |
2.4.1.206 | lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
cerebellum |
distinct cellular layers: Purkinje cell layer, molecular cell layer, granule cell layer + white matter |
638234, 638236 |
2.4.1.206 | lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
cerebellum |
neonatal |
638232 |
2.4.1.212 | hyaluronan synthase |
cerebellum |
- |
693368 |
2.4.1.214 | glycoprotein 3-alpha-L-fucosyltransferase |
cerebellum |
- |
661837 |
2.4.1.275 | neolactotriaosylceramide beta-1,4-galactosyltransferase |
cerebellum |
specific activities of Gal-Tr in the granule cell layer and white matter is approximately 66% of that in the molecular layer. Gal-Tr in the homogenate of cerebellum declines by approximately 35-45% from postnatal day 3 to 14. Gal-Tr activity in the granule cells does not change with age. The relative Gal-Tr activity in granule cells to homogenate is between 0.13 and 0.23 |
638234 |
2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase |
cerebellum |
- |
658240 |