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Information on EC 1.21.99.3 - thyroxine 5-deiodinase
for references in articles please use BRENDA:EC1.21.99.3
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EC Tree 1 Oxidoreductases
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.99 With unknown physiological acceptors
1.21.99.3 thyroxine 5-deiodinase
IUBMB Comments
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
The enzyme appears in viruses and cellular organisms
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
-
deiodination
- pituitary
-
euthyroidism
- 3,5,3'-triiodothyronine
- adipose
-
5'-deiodination
- propylthiouracil
- l-thyroxine
-
prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
-
selenoproteins
-
selenoenzyme
-
iopanoic
- methimazole
-
dlk1-dio3
-
pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
- amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
Reaction Schemes
showSynonyms
5'-deiodinase, type iii deiodinase, type 3 iodothyronine deiodinase, deiodinase 3, t4-5'-deiodinase, type iii iodothyronine deiodinase, dio3b, iodothyronine monodeiodinase, deiodinase-3, dio3a, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D3
deiodinase
deiodinase 3
deiodinase, thyroxine 5-
-
-
-
-
diiodothyronine 5'-deiodinase
-
-
-
-
Dio
Dio3
EC 1.97.1.11
-
-
formerly
-
iodothyronine 5-deiodinase
-
-
-
-
iodothyronine inner ring monodeiodinase
-
-
-
-
thyroxine 5-deiodinase
type 3 deiodinase
type 3 iodothyronine deiodinase
type III iodothyronine deiodinase
type III iodothyronine deiodinase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
all 3 isozyme types contain a selenocysteine residue at the active site
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
enzyme has both thyroxine 5-deiodinase and thyroxine 5'-deiodinase activities
-
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
inner ring deiodination
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
both 5'-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site
-
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
thyroid hormone metabolism I (via deiodination)
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SYSTEMATIC NAME
IUBMB Comments
3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
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CAS REGISTRY NUMBER
COMMENTARY
74506-30-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,3',5'-triido-L-thyronine + AH
3,3'-diiodothyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5'-triido-L-thyronine + iodide + A + H+
L-thyroxine + AH2
-
Substrates: assay at pH 7.2
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + reduced acceptor
3,3'-diiodo-L-thyronine + iodide + acceptor + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
Substrates: -
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
?
-
Substrates: assay at pH 7.0, 37Ā°C
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
3,5,3'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
Substrates: radioactive and unlabeled T3,in presence of 1 6-N-propylthiouracil, the products of deiodination are quantified by HPLC
Products: -
Products: -
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5',3'-triiodothyronine + iodide + A + H+
-
Substrates: i.e. thyroxine, reaction of isozyme Dio3
Products: i.e. reverse triiodothyrosine
Products: i.e. reverse triiodothyrosine
?
L-3,5,3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
Substrates: 5-deionination by isozyme Dio1
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triido-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: prefers T3 over T4 as substrate, bisubstrate sequential-type reaction mechanism
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: D3 terminates thyroid hormone action by by inactivating T3
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: type 3 deiodinase terminates thyroid hormone action by inactivating T3
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: no activity
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: type I isozyme
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: type I isozyme
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
Substrates: -
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
Substrates: -
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: best substrate
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: best substrate
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: selenocysteine residue in the active site is essential for efficient inner ring deiodination
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: best substrate
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: best substrate
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: best substrate
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: best substrate
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: no detectable activity in vivo, isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
Substrates: about 14% of the activity with 3,3',5-triiodo-L-thyronine
Products: -
Products: -
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
Substrates: highest substrate affinity for 3,5,3'-triiodo-L-thyronine
Products: -
Products: -
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
-
Substrates: phenolic ring deiodination of 3',5'-T2 by Dio2
Products: -
Products: -
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
-
Substrates: phenolic ring deiodination of 3',5'-T2 by Dio2
Products: -
Products: -
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
-
Substrates: tyrosyl ring deiodination of 3-iodothyronamine by isozyme Dio3
Products: -
Products: -
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
-
Substrates: tyrosyl ring deiodination of 3-iodothyronamine by isozyme Dio3
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: 5-deiodinase activity
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: selenocysteine residue in the active site is absolutely essential for efficient inner ring deiodination
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: in pre- and prometamorphic tadpoles, undetectable during metamorphic climax
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: very low activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: preferred substrate
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: type I isozyme
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: 5-deiodinase activity
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active
Products: from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: i.e. 3,3',5,5'-tetraiodo-L-thyronine
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: low activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5'-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: in vivo after entering metamorphic climax, low 5'-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
Substrates: no activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: preferred substrate
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5'-deiodinase activity
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5'-deiodinase activity
Products: from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
Products: from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type II
Products: -
Products: -
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type I
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme performs inactivation of thyroid hormones
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III is a oncofetal enzyme, regulation
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III is a oncofetal enzyme, regulation
Products: -
Products: -
?
additional information
?
-
-
Substrates: thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
additional information
?
-
-
Substrates: selenium-level of cells influences the enzyme activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme Dio1 exhibits both phenolic and tyrosyl ring deiodination activity while isozyme Dio2 catalyzes only deiodinations of the phenolic ring, isozyme Dio3 catalyzes only deiodinations of the tyrosyl ring. T3, 3,3'-T2, and 3,5-T2 are also not deiodinated by Dio1 from HepG2 lysates
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme activity is developmentally regulated, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III is a oncofetal enzyme, regulation
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
additional information
?
-
-
Substrates: thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme Dio1 from mouse liver membrane fractions catalyzes a weak 3'-deiodination of 3,3'-T2 as well as faint 5-deiodinations of both T3 and 3,5-T2
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III is a oncofetal enzyme, regulation
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
additional information
?
-
-
Substrates: 5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism
Products: -
Products: -
?
additional information
?
-
-
Substrates: placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme performs inactivation of thyroid hormones
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III is a oncofetal enzyme, regulation
Products: -
Products: -
?
additional information
?
-
-
Substrates: L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,3',5'-triiodo-L-thyronine + reduced acceptor
3,3'-diiodo-L-thyronine + iodide + acceptor + H+
-
Substrates: -
Products: -
Products: -
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: -
Products: -
?
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
Substrates: -
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
Substrates: -
Products: -
Products: -
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
Substrates: -
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: selenocysteine residue in the active site is essential for efficient inner ring deiodination
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
Substrates: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: hormonally inactive
Products: hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: isozyme type III
Products: i.e. 3,3'-diiodo-L-thyronine
Products: i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: no detectable activity in vivo, isozyme type III
Products: -
Products: -
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
Substrates: -
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: hormonally inactive
Products: hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
Substrates: 5-deiodinase activity
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
Substrates: 5-deiodinase activity
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
Products: enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?