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Information on EC 1.21.99.3 - thyroxine 5-deiodinase
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1.21.99.3 thyroxine 5-deiodinaseIUBMB Comments
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
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Word Map
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
-
deiodination
- pituitary
-
euthyroidism
- 3,5,3'-triiodothyronine
- adipose
-
5'-deiodination
- propylthiouracil
- l-thyroxine
-
prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
-
selenoproteins
-
selenoenzyme
-
iopanoic
- methimazole
-
dlk1-dio3
-
pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
- amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
5'-deiodinase, type iii deiodinase, type 3 iodothyronine deiodinase, deiodinase 3, t4-5'-deiodinase, type iii iodothyronine deiodinase, dio3b, iodothyronine monodeiodinase, deiodinase-3, dio3a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D3
deiodinase
deiodinase 3
deiodinase, thyroxine 5-
-
-
-
-
diiodothyronine 5'-deiodinase
-
-
-
-
Dio
Dio3
EC 1.97.1.11
-
-
formerly
-
iodothyronine 5-deiodinase
-
-
-
-
iodothyronine inner ring monodeiodinase
-
-
-
-
thyroxine 5-deiodinase
type 3 deiodinase
type 3 iodothyronine deiodinase
type III iodothyronine deiodinase
type III iodothyronine deiodinase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
all 3 isozyme types contain a selenocysteine residue at the active site
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
enzyme has both thyroxine 5-deiodinase and thyroxine 5'-deiodinase activities
-
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
inner ring deiodination
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
both 5'-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site
-
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
-
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SYSTEMATIC NAME
IUBMB Comments
3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
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CAS REGISTRY NUMBER
COMMENTARY
74506-30-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,3',5'-triido-L-thyronine + AH
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triido-L-thyronine + iodide + A + H+
L-thyroxine + AH2
-
assay at pH 7.2
-
-
?
3,3',5'-triiodo-L-thyronine + reduced acceptor
3,3'-diiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
3,5,3'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
radioactive and unlabeled T3,in presence of 1 6-N-propylthiouracil, the products of deiodination are quantified by HPLC
-
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5',3'-triiodothyronine + iodide + A + H+
-
i.e. thyroxine, reaction of isozyme Dio3
i.e. reverse triiodothyrosine
-
?
L-3,5,3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
5-deionination by isozyme Dio1
-
-
?
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
prefers T3 over T4 as substrate, bisubstrate sequential-type reaction mechanism
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
D3 terminates thyroid hormone action by by inactivating T3
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
type 3 deiodinase terminates thyroid hormone action by inactivating T3
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
no activity
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
type I isozyme
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
type I isozyme
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is essential for efficient inner ring deiodination
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
best substrate
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
best substrate
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
hormonally inactive
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
no detectable activity in vivo, isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine sulfate + AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H+
about 14% of the activity with 3,3',5-triiodo-L-thyronine
-
-
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
highest substrate affinity for 3,5,3'-triiodo-L-thyronine
-
-
?
3,5,3'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
-
phenolic ring deiodination of 3',5'-T2 by Dio2
-
-
?
L-3',5'-diiodothyronine + AH2
L-5'-iodothyronine + iodide + A + H+
-
phenolic ring deiodination of 3',5'-T2 by Dio2
-
-
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
-
tyrosyl ring deiodination of 3-iodothyronamine by isozyme Dio3
-
-
?
L-3-iodothyronine + AH2
L-thyronine + iodide + A + H+
-
tyrosyl ring deiodination of 3-iodothyronamine by isozyme Dio3
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive, enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is absolutely essential for efficient inner ring deiodination
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
in pre- and prometamorphic tadpoles, undetectable during metamorphic climax
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
very low activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
preferred substrate
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
type I isozyme
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isozyme type III
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
i.e. 3,3',5,5'-tetraiodo-L-thyronine
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
low activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
in vivo after entering metamorphic climax, low 5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
no activity
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
preferred substrate
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life
-
-
?
additional information
?
-
-
the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
selenium-level of cells influences the enzyme activity
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme Dio1 exhibits both phenolic and tyrosyl ring deiodination activity while isozyme Dio2 catalyzes only deiodinations of the phenolic ring, isozyme Dio3 catalyzes only deiodinations of the tyrosyl ring. T3, 3,3'-T2, and 3,5-T2 are also not deiodinated by Dio1 from HepG2 lysates
-
-
?
additional information
?
-
-
isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions
-
-
?
additional information
?
-
-
enzyme activity is developmentally regulated, overview
-
-
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