Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
acyl-CoA + sn-glycerol 3-phosphate
CoA + 2-acyl-sn-glycerol 3-phosphate
reaction of EC 2.3.1.198, glycerol-3-phosphate 2-O-acyltransferase
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + lysophosphatidic acid
acyl-[acyl-carrier protein] + glycerol-3-phosphate
[acyl-carrier protein] + lysophosphatidic acid
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
arachidonoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
arachidoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-arachidoyl-sn-glycerol 3-phosphate
-
-
-
-
?
cis-vaccenoyl-CoA + sn-glycerol 3-phosphate
CoA + cis-vaccenoyl-sn-glycerol 3-phosphate
cis-vaccenoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-cis-vaccenoyl-sn-glycerol 3-phosphate
dicarboxylic acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-dicarboxylic acyl-sn-glycerol 3-phosphate
-
-
-
?
dicarboxylic acyl-CoA + sn-glycerol 3-phosphate
CoA + 2-dicarboxylic acyl-sn-glycerol 3-phosphate
reaction of EC 2.3.1.198, glycerol-3-phosphate 2-O-acyltransferase
-
-
?
docosahexaenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-docosahexaenoyl-sn-glycerol 3-phosphate
eicosapentaenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-eicosapentaenoyl-sn-glycerol 3-phosphate
-
-
-
?
erucoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-erucoyl-sn-glycerol 3-phosphate
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
glycerol 3-phosphate + palmitoyl-CoA
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
lauroyl-CoA + glycerol-3-phosphate
CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
-
-
-
?
lauroyl-CoA + sn-glycerol 3-phosphate
CoA + 1-lauroyl-sn-glycerol 3-phosphate
linolenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linolenoyl-sn-glycerol 3-phosphate
linoleoyl-CoA + glycerol 3-phosphate
CoA + 1-linoleoyl-glycerol 3-phosphate
linoleoyl-CoA + glycerol-3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
n-decanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-decanoyl-sn-glycerol 3-phosphate
-
-
-
?
n-dodecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-dodecanoyl-sn-glycerol 3-phosphate
octanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-octanoyl-sn-glycerol 3-phosphate
-
very low activity
-
?
oleic acid-[acyl-carrier protein] + glycerol-3-phosphate
?
GPAT from chilling-resistant plants prefer 18:1-[acyl-carrier protein], oleic acid, to 16:0-[acyl-carrier protein], palmitic acid, as a substrate
-
-
?
oleoyl-CoA + glycerol 3-phosphate
CoA + 1-oleoyl-glycerol 3-phosphate
oleoyl-CoA + glycerol-3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
omega-hydroxy acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-omega-hydroxy acyl-sn-glycerol 3-phosphate
-
-
-
?
omega-hydroxy-acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-omega-hydroxy-acyl-sn-glycerol 3-phosphate
-
-
-
?
omega-hydroxy-acyl-CoA + sn-glycerol 3-phosphate
CoA + 2-omega-hydroxy-acyl-sn-glycerol 3-phosphate
reaction of EC 2.3.1.198, glycerol-3-phosphate 2-O-acyltransferase
-
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
palmitoyl-CoA + glycerol 3-phosphate
CoA + 1-palmitoyl-glycerol 3-phosphate
palmitoyl-CoA + glycerol-3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
preferred substrate is palmitoyl-CoA
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + palmitoyl-glycerol 3-phosphate
palmitoyl-[acyl carrier protein] + sn-glycerol 3-phosphate
holo-[acyl-carrier protein] + 1-palmitoylglycerol 3-phosphate
palmitoyl-[acyl-carrier protein] + glycerol-3-phosphate
[acyl-carrier protein] + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
stearoyl-CoA + glycerol 3-phosphate
CoA + 1-stearoyl-glycerol 3-phosphate
-
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
stearoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-stearoyl-sn-glycerol 3-phosphate
undecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-undecanoyl-sn-glycerol 3-phosphate
-
-
-
?
vaccenoyl-[acyl carrier protein] + sn-glycerol 3-phosphate
holo-[acyl-carrier protein] + 1-vaccenoylglycerol 3-phosphate
-
-
-
-
?
additional information
?
-
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
acyl-selectivity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
acyl-selectivity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
very low activity with butanoyl-CoA and hexanoyl-CoA
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
first committed step in biosynthesis of fatty acid biosynthesis, the enzyme is responsible for incorporation of saturated and unsaturated fatty-acyl chains into chloroplast membranes
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate, ethylene glycol phosphate and 1,3-propanediol phosphate can replace glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
preference for saturated fatty acyl-CoAs
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
temperature-dependent specificity of reconstituted enzyme
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated acyl-CoAs preferred
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
initial step in membrane phospholipid biosynthesis
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated acyl-CoAs preferred
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
key enzyme in de novo triacylglycerol synthesis
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
acyl-CoA specificity of GPAT1 is 16:0 > 18:0 > 18:1
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT2 shows no acyl-CoA specificity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT3 shows a specificity for 16:0, 18:1, 18:2 acyl-CoAs
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT3 uses oleoyl-CoA as the preferred substrate compared to all other acyl-CoAs such as palmitoyl-CoA, myristoyl-CoA, and stearoyl-CoA
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT4 shows no acyl-CoA specificity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
i.e. lysophosphatidic acid
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
no activity with hexanoyl-CoA, enzyme prefers saturated fatty acyl-CoAs
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
enzyme catalyzes the initial and rate-limiting step of glycerolipid synthesis with long-chain acyl-CoAs
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
key enzyme in de novo triacylglycerol synthesis
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
acylation of sn-glycerol 3-phosphate with longchain acyl-CoA
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
acyl-CoA specificity of GPAT1 is 16:0 > 18:0 > 18:1
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT2 shows no acyl-CoA specificity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT3 shows a specificity for 16:0, 18:1, 18:2 acyl-CoAs
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
GPAT4 shows no acyl-CoA specificity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
pulmonary enzyme acetylates C-1 and C-2-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
chloroplastic enzyme has no strict acyl-CoA specificity
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated acyl-CoAs preferred
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
initial reaction of glycolipid biosynthesis
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
no acyl-donors are hexanoyl-CoA, octanoyl-CoA
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated acyl-CoAs preferred
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated acyl-CoAs preferred
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
initial reaction of phosphoglycerol biosynthesis
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
the enzyme catalyzes the first and committed step in the synthesis of glycerophospholipids and TAG from sn-glycerol-3-phosphate
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
the enzyme catalyzes the first and committed step in the synthesis of glycerophospholipids and triacylglycerol from sn-glycerol-3-phosphate
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
broad specificity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
enzyme has both 3-glycerophosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activity
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
enzyme has both 3-glycerophosphate acyltransferase and dihydroxyacetonephosphate acyltransferase activity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
broad specificity
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
chloroplastic enzyme has no strict acyl-CoA specificity
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
dihydroxyacetone phosphate is ineffective as acyl-acceptor
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
initial reaction of glycolipid biosynthesis
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
first committed step in biosynthesis of fatty acid biosynthesis, the enzyme is responsible for incorporation of saturated and unsaturated fatty-acyl chains into chloroplast membranes
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
saturated and unsaturated acyl-CoAs are substrates
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
exclusively acylates glycerol 3-phosphate at the C-1-position
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
initial reaction of cocoa butter biosynthesis
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
the enzyme exhibits preference for medium length, unsaturated fatty acyl-CoAs, i.e. palmitoyl-CoA
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
the enzyme exhibits preference for medium length, unsaturated fatty acyl-CoAs, i.e. palmitoyl-CoA
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
acyl-CoA + sn-glycerol 3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
-
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
acyl-[acyl-carrier-protein] is probably the physiological substrate
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate, ACP-thioesters preferred over CoA-thioester
-
?
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate
-
specific for glycerol 3-phosphate, ACP-thioesters preferred over CoA-thioester
-
?
arachidonoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
-
20% of the reaction rate with palmitoyl-CoA
-
?
arachidonoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
-
-
-
?
arachidonoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
arachidonoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
cis-vaccenoyl-CoA + sn-glycerol 3-phosphate
CoA + cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
-
?
cis-vaccenoyl-CoA + sn-glycerol 3-phosphate
CoA + cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
?
cis-vaccenoyl-CoA + sn-glycerol 3-phosphate
CoA + cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
-
?
cis-vaccenoyl-CoA + sn-glycerol 3-phosphate
CoA + cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
?
cis-vaccenoyl-CoA + sn-glycerol 3-phosphate
CoA + cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
-
?
cis-vaccenoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
?
cis-vaccenoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-cis-vaccenoyl-sn-glycerol 3-phosphate
-
-
-
?
docosahexaenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-docosahexaenoyl-sn-glycerol 3-phosphate
-
-
-
?
docosahexaenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-docosahexaenoyl-sn-glycerol 3-phosphate
-
-
-
?
docosahexaenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-docosahexaenoyl-sn-glycerol 3-phosphate
-
-
-
?
erucoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-erucoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
erucoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-erucoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
erucoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-erucoyl-sn-glycerol 3-phosphate
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
long-chain fatty acyl-CoA
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
?
fatty acyl-CoA + glycerol-3-phosphate
CoA + lysophosphatidic acid
-
-
-
-
?
glycerol 3-phosphate + palmitoyl-CoA
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
glycerol 3-phosphate + palmitoyl-CoA
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
-
?
lauroyl-CoA + sn-glycerol 3-phosphate
CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
-
-
-
?
lauroyl-CoA + sn-glycerol 3-phosphate
CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
-
-
-
?
lauroyl-CoA + sn-glycerol 3-phosphate
CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
-
-
-
?
linolenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linolenoyl-sn-glycerol 3-phosphate
-
-
-
?
linolenoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linolenoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + glycerol 3-phosphate
CoA + 1-linoleoyl-glycerol 3-phosphate
-
preferred substrate linoleoyl-CoA (equal to palmitoyl-CoA)
-
-
?
linoleoyl-CoA + glycerol 3-phosphate
CoA + 1-linoleoyl-glycerol 3-phosphate
-
and palmitoyl-CoA, best substrates
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
40% of the reaction rate with palmitoyl-CoA
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
no substrate for DTNB-resistant isozyme
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
high activity
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
2% of activity with palmitoyl-CoA
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
linoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-linoleoyl-sn-glycerol 3-phosphate
-
-
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
-
-
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
-
-
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
i.e. tetradecanoyl-CoA
-
?
myristoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-myristoyl-sn-glycerol 3-phosphate
-
20% of activity with oleoyl-CoA
-
?
n-dodecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-dodecanoyl-sn-glycerol 3-phosphate
-
-
-
?
n-dodecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-dodecanoyl-sn-glycerol 3-phosphate
-
i.e. lauroyl-CoA, poor substrate
-
?
n-dodecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-dodecanoyl-sn-glycerol 3-phosphate
-
i.e. lauroyl-CoA, poor substrate
-
?
n-dodecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-dodecanoyl-sn-glycerol 3-phosphate
-
i.e. lauroyl-CoA, poor substrate
-
?
n-dodecanoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-n-dodecanoyl-sn-glycerol 3-phosphate
-
very low activity
-
?
oleoyl-CoA + glycerol 3-phosphate
CoA + 1-oleoyl-glycerol 3-phosphate
-
-
-
-
?
oleoyl-CoA + glycerol 3-phosphate
CoA + 1-oleoyl-glycerol 3-phosphate
-
moderate activity with oleoyl-CoA
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
preferred over palmitoyl-CoA with a ratio of approx. 3:1
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
preferred over palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
50% of the reaction rate with palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
isoenzyme AT1, preferred over palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
16% of the reaction rate with palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
16% of the reaction rate with palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
high activity
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
preferred substrate
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
preferred substrate
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
i.e. octadecenoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
preferred in an equimolar mixture of palmitoyl-CoA, stearoyl-CoA and oleoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
high activity
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
7% of activity with palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
low activity
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
slight preference over palmitoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
preferred in an equimolar mixture of palmitoyl-CoA, stearoyl-CoA and oleoyl-CoA
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
best acyl-donor
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
oleoyl-[acyl-carrier-protein] is preferred over palmitoyl-[acyl-carrier-protein]
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
no preference over palmitoyl- acyl-carrier-protein
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
most active acyl donor
-
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
best substrate
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
best substrate
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
-
-
?
oleoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-oleoyl-sn-glycerol 3-phosphate
-
best substrate
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
high activity
-
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
-
?
palmitoleoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + glycerol 3-phosphate
CoA + 1-palmitoyl-glycerol 3-phosphate
-
preferred substrate palmitoyl-CoA (equal to linoleoyl-CoA)
-
-
?
palmitoyl-CoA + glycerol 3-phosphate
CoA + 1-palmitoyl-glycerol 3-phosphate
-
and lineoyl-CoA, best substrates
-
-
?
palmitoyl-CoA + glycerol 3-phosphate
CoA + 1-palmitoyl-glycerol 3-phosphate
-
-
-
-
?
palmitoyl-CoA + glycerol-3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
-
?
palmitoyl-CoA + glycerol-3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
activity assay
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
wild-type acyltransferase uses palmitoyl-CoA and oleoyl-CoA at comparable rates, recombinant mutant acyltransferase prefers oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
stromal acyltransferase, preferred acyl-donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
4fold better substrate than oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
4fold better substrate than oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
high activity
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
recombinant mitochondrial acyltransferase prefers palmitoyl-CoA over oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
best acyl-donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
preferred substrate of isozyme mtGPAT1, not of isozyme mtGPAT2
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
microsomal enzyme, preferred over oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
i.e. lysophosphatidic acid
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
best acyl donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
best acyl donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
mitochondrial enzyme, preferred over oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
palmitoyl-CoA is preferred over oleoyl-CoA only in presence of albumin or acyl-CoA binding protein ACBP in young rat livers
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
best acyl donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
best acyl donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
preferred acyl-donor
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
i.e. n-hexadecanoyl-CoA, best substrate
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
20% of activity with oleoyl-CoA
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + palmitoyl-glycerol 3-phosphate
-
-
-
?
palmitoyl-CoA + sn-glycerol 3-phosphate
CoA + palmitoyl-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl carrier protein] + sn-glycerol 3-phosphate
holo-[acyl-carrier protein] + 1-palmitoylglycerol 3-phosphate
-
-
-
-
?
palmitoyl-[acyl carrier protein] + sn-glycerol 3-phosphate
holo-[acyl-carrier protein] + 1-palmitoylglycerol 3-phosphate
-
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
palmitoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-palmitoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
i.e. n-octadecanoyl-CoA, 30% of the reaction rate with palmitoyl-CoA
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
high activity
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
less than 20% of activity with palmitoyl-CoA
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
poor substrate
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
low activity
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-CoA + sn-glycerol 3-phosphate
CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
20% of activity with oleoyl-CoA
-
?
stearoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
stearoyl-[acyl-carrier protein] + sn-glycerol 3-phosphate
acyl-carrier protein + 1-stearoyl-sn-glycerol 3-phosphate
-
-
-
?
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
acyl-CoA ist the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-1 before sn-2
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
dicarboxylic acyl-CoA is the preferred substrate. The isozyme shows a regiospecificity that is equally sn-2 and sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
omega-hydroxy-acyl-CoA is the preferred substrate compared to dicarboxylic acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
regiospecificity of GPAT9, the majority of the acylation reactions catalyzed by this enzyme takes place at the sn-1 position rather than the sn-2 position (5.3:1 ratio)
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
the isozyme prefers very-long-chain (C22) acyl-Co as substrate compared to dicarboxylic acyl-CoA and omega-hydroxy acyl-CoA. The isozyme shows a regiospecificity that prefers sn-2 before sn-1
-
-
-
additional information
?
-
PLAT2 is a GPAT that transfers DHA to G3P in vivo as well as in vitro, substrate specificity, detailed overview
-
-
-
additional information
?
-
-
PLAT2 is a GPAT that transfers DHA to G3P in vivo as well as in vitro, substrate specificity, detailed overview
-
-
-
additional information
?
-
PLAT2 is a GPAT that transfers DHA to G3P in vivo as well as in vitro, substrate specificity, detailed overview
-
-
-
additional information
?
-
plastidial lysophosphatidic acid acyltransferase (CrLPAAT1, EC 2.3.1.51) is found to be interacting with the water-soluble plastidial glycerol-3-phosphate acyltransferase (CrGAPTcl) via its two transmembrane domains in vitro. The interaction between CrLPAAT1 and CrGPATcl can be negatively regulated by both the acyl-CoAs and lysophosphatidic acid in a dosage-dependent manner. Recombinant CrLPAAT1(wild-type) and CrLPAAT1(mut) and the control Trx-S-His6-tag protein in concentration gradients are incubated with the immobilized CrGPATcl, respectively. These recombinant proteins except CrGPATcl have the S tag and can be detected by anti-S tag antibody. Simultaneously, anti-CrGPATcl antibody is used for interaction detection in Western blotting. Kinetics of the CrLPAAT1-CrGPATcl interaction, overview. The stability of CrLPAAT1-CrGPATcl complex is inversely proportional to the concentrations of acyl donors used in the assays, and it is most sensitive to the high-concentration of C18:1 (n9)-CoA among various acyl donors
-
-
-
additional information
?
-
-
the content of cis-unsaturated fatty acids in the plastidial phosphatidyl glycerol determines the degree of sensitivity to chilling, the higher it is the more tolerant are the plants to chilling, squash is chilling-sensitive, overview
-
-
?
additional information
?
-
-
substrate specificity of wild-type and chimeric mutant enzymes, overview
-
-
?
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
the isozyme GPAT3 possesses both AGPAT and GPAT activities. Microsomal GPAT3 catalyzes a broad range of reactions using long-chain acyl-CoA as substrates, including saturated and unsaturated FAs. GPAT3 uses oleoyl-CoA as the preferred substrate compared to all other acyl-CoAs such as palmitoyl-CoA, myristoyl-CoA, and stearoyl-CoA
-
-
-
additional information
?
-
the isozyme GPAT3 possesses both AGPAT and GPAT activities. Microsomal GPAT3 catalyzes a broad range of reactions using long-chain acyl-CoA as substrates, including saturated and unsaturated FAs. GPAT3 uses oleoyl-CoA as the preferred substrate compared to all other acyl-CoAs such as palmitoyl-CoA, myristoyl-CoA, and stearoyl-CoA
-
-
-
additional information
?
-
the isozyme GPAT3 possesses both AGPAT and GPAT activities. Microsomal GPAT3 catalyzes a broad range of reactions using long-chain acyl-CoA as substrates, including saturated and unsaturated FAs. GPAT3 uses oleoyl-CoA as the preferred substrate compared to all other acyl-CoAs such as palmitoyl-CoA, myristoyl-CoA, and stearoyl-CoA
-
-
-
additional information
?
-
-
enzyme important for the synthesis of triacylglycerol but not essential for virulence
-
-
?
additional information
?
-
-
the mitochondrial and microsomal isozymes show different substrate specificity
-
-
?
additional information
?
-
-
mtGPAT1 is essential for normal acyl-CoA metabolism: The absence of hepatic mtGPAT1 results in the partitioning of fatty acids away from triacylglycerol synthesis and toward oxidation and ketogenesis
-
-
?
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway
-
-
-
additional information
?
-
-
aging and acyl-CoA binding protein alter mitochondrial enzyme activity
-
-
?
additional information
?
-
-
in biochemical studies, saturated fatty acyl-CoAs are preferred approximately 2fold over unsaturated fatty acyl-CoAs as GPAT1 substrates. Esterification occurs at the sn-1 position of glycerol 3-phosphate
-
-
?
additional information
?
-
in biochemical studies, saturated fatty acyl-CoAs are preferred approximately 2fold over unsaturated fatty acyl-CoAs as GPAT1 substrates. Esterification occurs at the sn-1 position of glycerol 3-phosphate
-
-
?
additional information
?
-
-
the content of cis-unsaturated fatty acids in the plastidial phosphatidyl glycerol determines the degree of sensitivity to chilling, the higher it is the more tolerant are the plants to chilling, spinach is chilling-insensitive, while squash is chilling-sensitive, overview
-
-
?
additional information
?
-
-
substrate specificity of the chimeric mutant enzymes, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
evolution
GPAT9 is the homologue of a microsomal GPAT involved in the production of storage oil in mammalian cells
evolution
phylogenetic analysis of GPAT homologues
evolution
phylogenetic analysis of MS33
evolution
PLAT2 is highly homologous to the GPAT isozymes 3 and 4
evolution
-
phylogenetic analysis of GPAT homologues
-
evolution
-
PLAT2 is highly homologous to the GPAT isozymes 3 and 4
-
malfunction
GPAT1 -/- mice contain reduced amounts of C16:0 and increased C18:0 and C18:1 in liver phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholine and phosphatidylethanolamine in Gpat1-/- liver also contain 40% more C20:4 at the sn-2 position, suggesting that esterification at the sn-2 position is influenced by fatty acids at the sn-1 position. GPAT1 overexpression in liver of mice leads to increased incorporation of C16:0 fatty acids into lysophosphatidic acid, diacylglycerol, triacylglycerol
malfunction
GPAT1 overexpression in rat primary hepatocytes results in the increased incorporation of exogenous fatty acids into triacylglycerol and phospholipids and reduced rate of beta-oxidation
malfunction
GPAT1-deficient mice fed a high-fat/high sucrose diet have reduced hepatic triacylglycerol but increased plasma beta-hydroxybutyrate and liver acylcarnitine levels, suggesting enhanced beta-oxidation. In the high-fat-fed GPAT1-deficient mice, elevated beta-oxidation is associated with increased hepatic acyl-CoA content and activation state of AMP-activated protein kinase. These results suggest that enhanced beta-oxidation represents increased energy flow to fatty acid oxidation caused by a blockage of the glycerolipid synthesis pathway. In GPAT1-overexpressing mice, liver fatty acid oxidation measured ex vivo is decreased. Due to the enhanced beta-oxidation in Gpat1-/- mice, liver mitochondria exhibit a greater mitochondrial dysfunction (oxidative stress, increased hepatocyte apoptosis, lower level odf DNA repair genes)
malfunction
GPAT3 overexpression in human embryonic kidney (HEK)-293 cells leads to increased incorporation of exogenous oleic acid into triacylglycerol but not into phospholipids. GPAT3 overexpression in HEK-293 cells increases phosphorylation of p70 S6 kinase and 4E-binding protein 1 in an mTOR (mammalian target of rapamycin)-dependent manner, suggesting the possible involvement of lipid intermediates of TAG synthesis, such as lysophosphatidic acid and phosphatidic acid (PA), in the mTOR pathway
malfunction
Gpat4-/- mice have severely impaired lactation, a reduced size and number of alveoli, reduced numbers of fat droplets in mammary gland, and reduced triacylglycerol and diacylglycerol content in milk. Gonadal white adipose tissue mass and plasma leptin levels are reduced in Gpat4-/- mice, and subdermal adipose tissue, is nearly absent. The reduced body weight of Gpat4-/- mice is associated with increased energy expenditure
malfunction
in GPAT1-overexpressing rats, hepatic acyl-CoA content and plasma beta-hydroxybutyrate concentration are similar to those of control rats
malfunction
-
livers and hearts from mice deficient in GPAT1 (Gpat1 -/-) have a decreased content of glycerolipid intermediates and triacylglycerol, an altered composition of liver phospholipids, and elevated markers of oxidative stress. Compared with control C57BL/6 mice, infection of Gpat1 -/- mice with coxsackievirus B3 results in higher mortality, an 50% increase in heart pathology, a significant increase in liver viral titers, and a 100fold increase in heart viral titers. Heart mRNA levels for proinflammatory cytokines TNF-alpha, IL-6, and IL-1B are increased in the Gpat1-/- mice. Loss of Gpat1 also results in dysregulation of specific immune cells
malfunction
-
loss of function of Gat1p and Gat2p is masked by the compensatory effect of their redundant partner. The complete lack of GPAT results in cell death, with multibudded cells containing divided nuclei
malfunction
-
T-lymphocyte proliferation is inhibited and activation induced apoptosis is increased in GPAT-1 knockout mice. Th-1 (IL-2 and IFN-gamma) cytokine secretion is reduced, and Th-2 (IL-4 and IL-10) cytokine secretion is increased. An increased arachidonate content and subsequent increased prostaglandin E2 secretion is shown in knockout mice, which may inhibit T-lymphocyte proliferation
malfunction
a knockout mutant of isoform GPAT9 demonstrates both male and female gametophytic lethality phenotypes
malfunction
-
enzyme deficiency results in altered or dysfunctional mitochondria
malfunction
-
enzyme deficiency results in an inherent defect in Jurkat T cell function and glycerophospholipid composition
malfunction
-
enzyme knockdown significantly impairs the ability of females to attract males
malfunction
in hepatocytes, the absence of isoform GPAT-1, but not GPAT-4, increases fatty acid oxidation and increases ketogenesis during fasting
malfunction
alteration of constitutive GPAT9 expression has no obvious effects on surface lipid biosynthesis. But overexpression and downregulation of GPAT9 in Arabidopsis thaliana results in changes in seed size, as well as seed oil content and composition. Altering the constitutive expression of GPAT9 in Arabidopsis enhances production of lipid droplets in pollen grains. Knockout of gpat9 has been shown to result in a male gametophytic lethality phenotype
malfunction
changes in fatty acid composition regulated by overexpression of GPAT, changes in fatty acid composition in transgenic and wild-type microalgae, overview
malfunction
gene disruption Gpat3-/- mutant mice exhibit attenuated plasma triglyceride excursion and accumulate lipid in the enterocytes, and a lack of lipids in the lamina propria and intercellular space in Gpat3-/- mice. Gpat3-/- enterocytes display a compensatory increase in the synthesis of phospholipid and cholesteryl ester. When fed a Western-type diet, hepatic triglyceride and cholesteryl ester accumulation is significantly higher in Gpat3-/- mice compared with the wild-type mice accompanied by elevated levels of alanine aminotransferase, a marker of liver injury. Dysregulation of bile acid metabolism is also evident in Gpat3-null mice. Although wild-type mice show marked lipid staining in the lamina propria, Gpat3-/- mice exhibit a striking reduction in transitory lipids. Phenotype overview. Analysis of effects of GPAT3 deletion on intestinal lipid profile, gene expression, and gut nutrient sensing
malfunction
GPAT activity is reduced by disruption of the PLAT2 gene in Aurantiochytrium limacinum, resulting in a decrease in DHA-containing lysophosphatidic acid (LPA 22:6). Conversely, overexpression of PLAT2 increases both GPAT activity and LPA 22:6. Overexpression of the PLAT2 gene increases the production of a two DHA-containing diacylglycerol (DG 44:12), followed by an increase in the three DHA-containing triacylglycerol (TG 66:18), two-DHA-containing TG (TG 60:12), and two DHA-containing phosphatidylcholine (PC 44:12). Overexpression of PLAT2 does not increase DHA-free DG (DG32:0), which is preferentially converted to three 16:0-containing TG (TG 48:0) but not two 16:0-containing PC (PC 32:0)
malfunction
GPAT2 mutant seeds show reduced germination rates and root lengths compared to wild-type in presence of 50-150 mM salt. Overexpression of glycerol-3-phosphate acyltransferase from Suaeda salsa improves salt tolerance in Arabidopsis thaliana deficient in GPAT2. In the seedling stage, chlorophyll content, the photochemical efficiency of PSII, PSI oxidoreductive activity (1I/Io), and the unsaturated fatty acid content of PG decrease less in overexpressing strains and more in mutant strains than that in wild-type under salt stress. The overexpression of SsGPAT alleviates the photoinhibition of PSII and PSI under salt stress by improving the unsaturated fatty acid content of phosphatidylglycerol (PG)
malfunction
Gpat3-/- mice have about 80% reduction in GPAT activity in white adipose tissue, are resistant to weight gain and have improved insulin sensitivity in response to a high-fat diet. In enterocytes from Gpat3-/- mice, excess fatty acids are oxidized and esterified to cholesterol, which are stored and secreted in chylomicrons. Gpat3-/- mice fed a high-fat diet have decreased weight gain, fat mass and enlarged livers, indicating an important role in fatty acid storage in white adipose tissue. Liver enlargement in Gpat3-/- mice is due to cholesterol ester storage resulting from dysregulation of intestinal cholesterol secretion. Overexpression of endoplasmic reticulum-localized GPAT3 or GPAT4 in cultured cells does not affect incorporation of exogenous fatty acids into the major phospholipid classes
malfunction
knockdown of GPAT3 and 4 almost completely prevents the formation of lipid droplets. Deficiency of GPAT greatly reduces TAG synthesis and impairs adipogenesis
malfunction
knockdown of GPAT3 and 4 almost completely prevents the formation of lipid droplets. Deficiency of GPAT greatly reduces TAG synthesis and impairs adipogenesis. Phenotype of GPAT4 knockout mice, overview. The body weight is significantly lower (25%) in GPAT4-/- mice fed with normal chow diet compared to that of the mice in the wild-type group. High fat diet-fed GPAT4-null mice exhibit increased thermogenic gene expression in brown adipose tissue and perform a dramatic hyper-metabolism. The levels of triacylglycerol and diacylglycerol of milk decreases by 90% in GPAT4-null mice due to an extraordinary decline in the number and size of fat droplets in mammary epithelial acinars and ducts. Pups nursed by GPAT4-/- mice die within 48 h after birth unless wild-type mice replace the GPAT4-/- mice to feed the pups. GPAT4 overexpression in hepatocytes leads to impaired insulin-suppressed gluconeogenesis and decreased insulin-stimulated glycogen synthesis, as well as inhibited phosphorylation of Akt (Ser473 and Thr308) stimulated by insulin. Eventually, the changes lead to the impaired glucose homeostasis. Overexpression of GPAT4 inhibits the association between rictor and the mTOR, and even the mTORC2 (mTOR complex 2) activity. Like GPAT1, overexpression of GPAT4 increases the content of phosphatidic acid, which is produced in triacylglycerol synthesis pathway, particularly di16:0-phosphatidic acid. The lipid signal (such as di16:0PA) produced by GPAT4 interferes with the insulin signaling in hepatocytes of mice, which results in hepatic insulin resistance and impaired glucose homeostasis
malfunction
knockdown of GPAT3 and 4 almost completely prevents the formation of lipid droplets. Deficiency of GPAT greatly reduces TAG synthesis and impairs adipogenesis. The activity of GPAT decreases dramatically with GPAT3-specific siRNA knockdown in 3T3-L1 cells, which directly inhibits lipid synthesis. GPAT3-/- mice have increased energy expenditure, improved glucose homeostasis (lower fed glucose level, but not fasting glucose and insulin levels), decreased fat pad size, altered serum lipid levels (increased plasma free cholesterol, especially the low-density lipoprotein cholesterol level, and decreased plasma TAG), but enlarged liver size with increased plasma ALT/AST levels. Inhibition of GPAT3 may improve lipid and glucose metabolism, and provide beneficial effects in the treatment of metabolic diseases. Though increased energy expenditure is observed in both female and male mice. A sexual dimorphism in the GPAT3-deficient phenotype is demonstrated. GPAT3-/- female mice are protected from dietary-induced obesity (DIO) and the hepatic cholesterol metabolism is primarily altered only in GPAT3-/- male mice
malfunction
lipid profile analyses of the transgenic yeasts validate the acylation function of LiGPAT and also indicate that mutation R195H leads to an increase in the phospholipid level in yeast, caused by the enlarged accessible surface of the phosphate group binding pocket when Arg195 is mutated to His
malfunction
loss of function of OsGPAT3 expression in tapetum and microspores disrupts tapetum development and metabolism, leading to defective anther cuticle and pollen exine formation. Compared with wild-type plants, the osgpat3 mutant displays smaller, pale yellow anthers with defective anther cuticle, degenerated pollen with defective exine, and abnormal tapetum development and degeneration. Anthers of the osgpat3 mutant have dramatic reductions of all aliphatic lipid contents. The defective cuticle and pollen phenotype coincide well with the down-regulation of sets of genes involved in lipid metabolism and regulation of anther development. The enzyme-deficient osgpat3 mutant exhibits normal vegetative development and inflorescence morphology, but has pale yellow to white and much smaller anthers compared with those of the wild-type and lacks mature pollen grains at the late stages of anther development, phenotype, detailed overview
malfunction
loss-of-function mutant atgpat9 displays a lethal embryo phenotype, suggesting the essential role of GPAT9 in membrane lipid synthesis
malfunction
overexpression of endoplasmic reticulum-localized GPAT3 or GPAT4 in cultured cells does not affect incorporation of exogenous fatty acids into the major phospholipid classes
malfunction
-
overexpression of glycerol-3-phosphate acyltransferase from Suaeda salsa improves salt tolerance in Arabidopsis thaliana deficient in GPAT (Arabidopsis thaliana mutants of gpat2 and gpat6)
malfunction
overexpression of GPAT1 in CHO, HEK-293 and primary rodent hepatocytes is sufficient to increase fatty acid incorporation into triglycerides and phospholipids. Gpat1-/- mice have a severe block in hepatic de novo synthesis of total phospholipids. Knockout of GPAT1 activity in cardiomyocytes and hepatocytes increases the arachidonate and oleate content of phosphocholine and phosphoethanolamine. Gpat1-/- mice are less susceptible to carcinogen-induced liver tumorigenesis. Gpat1-/- mice fed a high-sucrose diet to stimulate de novo lipogenesis have a 50% reduction in hepatic and plasma triglycerides, increased hepatic content of long-chain acylcarnitines and reduced very low density lipoprotein (VLDL) secretions. Liver-specific adenoviral expression of GPAT1 results in triglycerides and diacylglycerol accumulation, decreased fatty acid beta-oxidation, and hyperlipidemia
malfunction
overexpression of GPAT1 in CHO, HEK-293 and primary rodent hepatocytes is sufficient to increase fatty acid incorporation into triglycerides and phospholipids. Knockout of GPAT1 activity in cardiomyocytes and hepatocytes increases the arachidonate and oleate content of phosphocholine and phosphoethanolamine
malfunction
the alteration of lipid composition in GPAT1-/- mice decreases the susceptibility to carcinogen-induced liver tumorigenesis. Furthermore, although the changes in cellular metabolism associated with increased GPAT1 expression lead to overall ameliorative survival in breast cancer
malfunction
the enzyme mutant plants show substantial reduction in wax and cutin in ms33 anthers compared to wild-type. The maize male-sterile mutant shrinking anther 1 (sa1), which is allelic to the classic mutant male sterile 33 (ms33), displays defective anther cuticle development and premature microspore degradation. Male-sterile mutant sa1 phenotype compared to wild-type, overview. Female fertility is not affected in sa1, but the microspores of sa1 appear irregular, the anther layers appear collapsed, and the microspores are defective. At the mature pollen grain stage, in wild-type anthers, many pollen grains are present in the anther locule, whereas in sa1 anthers, no pollen grains are observed, and only some residual debris remain. Comparison of cutin and wax compositions of wild-type and mutant enzymes
malfunction
the enzyme null mutant exhibits a slight decrease in phosphatidylethanolamine biosynthesis that is compensated with a modest increase in production of ether phosphatidylcholine. TbGAT null mutant in Trypanosoma brucei procyclic forms lacks glycerol-3-phosphate acyltransferase activity, but remains viable and exhibits similar growth rate as the wild-type
malfunction
the gene is silenced in vivo by inoculating lentiviral particles carrying the sequence of a short-hairpin RNA targeting Gpat2 mRNA into mouse testis. Histological and gene expression analysis shows impaired spermatogenesis and arrest at the pachytene stage. The enzyme deficiency triggers apoptotic mechanisms and affects reproductive capacity
malfunction
the liver and brown adipose tissue of Gpat4-/- mice have a 65% reduction in NEM-sensitive GPAT activity, but activity in white adipose tissue is unaffected due to high levels of GPAT3 expression. Female Gpat4-/- mice fed a high-fat diet have increased PPARgamma-mediated Ucp1 expression and thermogenesis in brown adipose tissue resulting from elevated acyl-CoAs due to diminished esterification. Incorporation of exogenous oleate into phospholipid is unaffected in tissues of Gpat4-/- mice. Overexpression of endoplasmic reticulum-localized GPAT3 or GPAT4 in cultured cells does not affect incorporation of exogenous fatty acids into the major phospholipid classes
malfunction
the phagocytic capacity of Gpat3-/- and Gpat4-/- bone marrow-derived macrophages is impaired. Additionally, inhibiting fatty acid beta-oxidation reduces phagocytosis only partially, suggesting that lipid accumulation is not necessary for the energy requirements for phagocytosis
malfunction
the phagocytic capacity of Gpat3-/- and Gpat4-/- bone marrow-derived macrophages is impaired. Additionally, inhibiting fatty acid beta-oxidation reduces phagocytosis only partially, suggesting that lipid accumulation is not necessary for the energy requirements for phagocytosis. Gpat4-/- bone marrow-derived macrophages express and release more pro-inflammatory cytokines and chemokines after macrophage activation
malfunction
the T-cell phenotype under GPAT1 deficiency is comparable to that in an older mice, where GPAT1 activity decreases largely due to immune depression and results in increased susceptibility to infections. T-cells harvested from GPAT1-/- mice show significant reduction in interleukin-2 secretion upon antigen stimulation, and induced apoptosis accompanied by altered mass and composition of phospholipids. LPA produced as a result of increased expression of GPAT1 via glucosamine prevents mouse embryonic stem cells from hypoxia-induced apoptosis through the mammalian target of repamycin (mTOR) activation. The alteration of lipid composition in GPAT1-/- mice decreases the susceptibility to carcinogen-induced liver tumorigenesis. GPAT1 deficiency in ob/ob mice leads to a decrease in hepatic steatosis, triacylglycerol (about 59%), and diacylglycerol (about 74%), leading to the improvement of hepatic and systemic insulin sensitivity. The GPAT1-null mice also exhibit significant decreased plasma glucose levels and lowered plasma TAG content in ob/ob background. The levels of acyl-CoA are observed to be elevated. The overexpression of GPAT1 leads to impaired insulin signaling, reduced insulin-induced suppression of gluconeogenesis, substantially prevents mTOR complex2 (mTORC2) activity, and disassembles the link of mTOR/rictor mediated by PA, which induces peripheral and hepatic insulin resistance
malfunction
-
changes in fatty acid composition regulated by overexpression of GPAT, changes in fatty acid composition in transgenic and wild-type microalgae, overview
-
malfunction
-
lipid profile analyses of the transgenic yeasts validate the acylation function of LiGPAT and also indicate that mutation R195H leads to an increase in the phospholipid level in yeast, caused by the enlarged accessible surface of the phosphate group binding pocket when Arg195 is mutated to His
-
malfunction
-
GPAT2 mutant seeds show reduced germination rates and root lengths compared to wild-type in presence of 50-150 mM salt. Overexpression of glycerol-3-phosphate acyltransferase from Suaeda salsa improves salt tolerance in Arabidopsis thaliana deficient in GPAT2. In the seedling stage, chlorophyll content, the photochemical efficiency of PSII, PSI oxidoreductive activity (1I/Io), and the unsaturated fatty acid content of PG decrease less in overexpressing strains and more in mutant strains than that in wild-type under salt stress. The overexpression of SsGPAT alleviates the photoinhibition of PSII and PSI under salt stress by improving the unsaturated fatty acid content of phosphatidylglycerol (PG)
-
malfunction
-
the phagocytic capacity of Gpat3-/- and Gpat4-/- bone marrow-derived macrophages is impaired. Additionally, inhibiting fatty acid beta-oxidation reduces phagocytosis only partially, suggesting that lipid accumulation is not necessary for the energy requirements for phagocytosis
-
malfunction
-
the phagocytic capacity of Gpat3-/- and Gpat4-/- bone marrow-derived macrophages is impaired. Additionally, inhibiting fatty acid beta-oxidation reduces phagocytosis only partially, suggesting that lipid accumulation is not necessary for the energy requirements for phagocytosis. Gpat4-/- bone marrow-derived macrophages express and release more pro-inflammatory cytokines and chemokines after macrophage activation
-
malfunction
-
knockdown of GPAT3 and 4 almost completely prevents the formation of lipid droplets. Deficiency of GPAT greatly reduces TAG synthesis and impairs adipogenesis. Phenotype of GPAT4 knockout mice, overview. The body weight is significantly lower (25%) in GPAT4-/- mice fed with normal chow diet compared to that of the mice in the wild-type group. High fat diet-fed GPAT4-null mice exhibit increased thermogenic gene expression in brown adipose tissue and perform a dramatic hyper-metabolism. The levels of triacylglycerol and diacylglycerol of milk decreases by 90% in GPAT4-null mice due to an extraordinary decline in the number and size of fat droplets in mammary epithelial acinars and ducts. Pups nursed by GPAT4-/- mice die within 48 h after birth unless wild-type mice replace the GPAT4-/- mice to feed the pups. GPAT4 overexpression in hepatocytes leads to impaired insulin-suppressed gluconeogenesis and decreased insulin-stimulated glycogen synthesis, as well as inhibited phosphorylation of Akt (Ser473 and Thr308) stimulated by insulin. Eventually, the changes lead to the impaired glucose homeostasis. Overexpression of GPAT4 inhibits the association between rictor and the mTOR, and even the mTORC2 (mTOR complex 2) activity. Like GPAT1, overexpression of GPAT4 increases the content of phosphatidic acid, which is produced in triacylglycerol synthesis pathway, particularly di16:0-phosphatidic acid. The lipid signal (such as di16:0PA) produced by GPAT4 interferes with the insulin signaling in hepatocytes of mice, which results in hepatic insulin resistance and impaired glucose homeostasis
-
malfunction
-
GPAT activity is reduced by disruption of the PLAT2 gene in Aurantiochytrium limacinum, resulting in a decrease in DHA-containing lysophosphatidic acid (LPA 22:6). Conversely, overexpression of PLAT2 increases both GPAT activity and LPA 22:6. Overexpression of the PLAT2 gene increases the production of a two DHA-containing diacylglycerol (DG 44:12), followed by an increase in the three DHA-containing triacylglycerol (TG 66:18), two-DHA-containing TG (TG 60:12), and two DHA-containing phosphatidylcholine (PC 44:12). Overexpression of PLAT2 does not increase DHA-free DG (DG32:0), which is preferentially converted to three 16:0-containing TG (TG 48:0) but not two 16:0-containing PC (PC 32:0)
-
malfunction
-
the enzyme null mutant exhibits a slight decrease in phosphatidylethanolamine biosynthesis that is compensated with a modest increase in production of ether phosphatidylcholine. TbGAT null mutant in Trypanosoma brucei procyclic forms lacks glycerol-3-phosphate acyltransferase activity, but remains viable and exhibits similar growth rate as the wild-type
-
metabolism
isoform GPAT-1, but not GPAT-4, metabolizes fatty acid synthesized de novo from [14C]acetate and diverts fatty acids away from mitochondrial oxidation
metabolism
-
the enzyme contributes to triacylglycerol biosynthesis, lipid droplet formation, and host invasion in Metarhizium robertsii
metabolism
the enzyme is involved in triacylglycerol biosynthetic pathway
metabolism
de novo fatty acid biosynthesis occurs exclusively in plastids, and glycerolipids are synthesized via prokaryotic pathway in the plastids and eukaryotic pathway in the endoplasmic reticulum. The synthesized fatty acyl-acyl carrier protein (ACP) or acyl-CoA is esterified to glycerol-3-phosphate by glycerol-3-phosphate acyltransferase (GPAT), overview. GPAT9 catalyzes the first step in the synthesis of membrane lipids and triacylglycerol (TAG)
metabolism
enzyme GPAT is involved in the glycerolipid synthesis, it is the first and rate-limiting enzyme of the pathway. Glycerolipid synthesis and GPAT3/GPAT4 activity are induced during macrophage activation. Macrophage activation stimulates lipid droplet formation and increases triacylglycerol and phospholipid content, after Kdo2-lipid A (KLA) activation
metabolism
glycerol-3-phosphate acyltransferase (GPAT) is the critical enzyme that catalyzes the first step of triacylglycerol (TAG) formation, it is involved in the lipid metabolism of the diatom
metabolism
-
glycerol-3-phosphate acyltransferase (GPAT) is the first acyl esterifying enzyme in phosphatidylglycerol (PG) synthesis process
metabolism
glycerol-3-phosphate acyltransferase (GPAT) is the first acyl esterifying enzyme in phosphatidylglycerol (PG) synthesis process
metabolism
GPAT3 is involved in intestinal lipid metabolism, role of the intestinal glycerol 3-phosphate pathway in dietary lipid absorption. During lipid absorption, enterocytes transiently store triglycerides in cytosolic lipid droplets before packaging and secretion in chylomicron particles, isozyme Gpat3 localizes in the proximity to lipid droplets
metabolism
in microalgae, de novo biosynthesis of triacylglycerol (TAG) via the Kennedy pathway involves successive acylation of glycerol-3-phosphate (G-3-P) by glycerol-3-phosphate acyltransferase (GPAT, EC 2.3.1.15), lysophosphatidic acid acyltransferase (LPAAT, EC 2.3.1.51) and diacylglycerol acyltransferase (DGAT, EC 2.3.1.20). Microalgal plastidial lysophosphatidic acid acyltransferase (LPAAT1, EC 2.3.1.51) interacts with upstream glycerol-3-phosphate acyltransferase and defines its substrate selectivity via the two transmembrane domains. The interaction between LPAAT1 and GPATcl can be negatively regulated by both the acyl-CoAs and lysophosphatidic acid, regulation pattern, overview
metabolism
PLAT2 is a rate-limiting enzyme in docosahexaenoic acid (DHA)-rich glycerolipid synthesis in Aurantiochytrium limacinum
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway. These intermediate substrates serve as the critical component of the ubiquitous biological membranes and mediate intercellular signal transduction. Mitochondrial GPAT1 is a critical regulator of triacylglycerol metabolism and systemic energy homeostasis
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway. These intermediate substrates serve as the critical component of the ubiquitous biological membranes and mediate intercellular signal transduction. Mitochondrial GPAT1 is a critical regulator of triacylglycerol metabolism and systemic energy homeostasis
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT2 may play an important role in the regulation of reproductive system
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT3 and GPAT4 enzyme activity can be regulated by insulin upon phosphorylation at the Thr and Ser residues
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT3 and GPAT4 enzyme activity can be regulated by insulin upon phosphorylation at the Thr and Ser residues. Lysophosphatidic acid (LPA) produced by GPAT4 can stimulate mitogenic activity. LPA serves as a mitogen regulating various cellular processes, such as cell proliferation and cytoskeletal reorganization. Like mitochondrial GPAT1, GPAT4 is also associated with hepatic lipid accumulation and contributes to the development of insulin resistance
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT3 is recognized as a major isoform in the adipocytes for the synthesis of triacylglycerol. GPAT3 and GPAT4 enzyme activity can be regulated by insulin upon phosphorylation at the Thr and Ser residues. GPAT3 serves as an enzyme, playing critical roles in dietary lipid absorption, enteric and hepatic lipid homeostasis, as well as entero-endocrine hormone production. GPAT3 has been shown to be involved in the regulation of intestinal lipid metabolism, thyroid-stimulating hormone (TSH) induces lipid production by activating the PPARgamma/AMPK/GPAT3 pathway in a thyroxine-independent manner
metabolism
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, role of GPAT2 in lipid metabolism, overview
metabolism
substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids. The successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid (PA), a precursor for CDP-diacylglycerol-dependent phospholipid synthesis. PA is further dephosphorylated by LIPINs to produce diacylglycerol (DG), a substrate for the synthesis of triglyceride (TG) by DG acyltransferases and a precursor for phospholipid synthesis via the CDP-choline and CDP-ethanolamine (Kennedy) pathways. The channeling of fatty acids into TG for storage in lipid droplets and secretion in lipoproteins or phospholipids for membrane biogenesis is dependent on isoform expression, activity and localization of G3P pathway enzymes, as well as dietary and hormonal and tissue-specific factors. Mechanisms that control partitioning of substrates into lipid products of the G3P pathway, overview
metabolism
substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids. The successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid (PA), a precursor for CDP-diacylglycerol-dependent phospholipid synthesis. PA is further dephosphorylated by LIPINs to produce diacylglycerol (DG), a substrate for the synthesis of triglyceride (TG) by DG acyltransferases and a precursor for phospholipid synthesis via the CDP-choline and CDP-ethanolamine (Kennedy) pathways. The channeling of fatty acids into TG for storage in lipid droplets and secretion in lipoproteins or phospholipids for membrane biogenesis is dependent on isoform expression, activity and localization of G3P pathway enzymes, as well as dietary and hormonal and tissue-specific factors. Mechanisms that control partitioning of substrates into lipid products of the G3P pathway, overview
metabolism
the enzyme catalyzes the initial step of glycerophospholipid biosynthesis in the mycobacterial cell, pathway overview
metabolism
the preference of GPAT9 for acyl-CoA as its substrate, and its sn-1 regio-specificity, provide support that it plays an important role in the Kennedy pathway of glycerolipid biosynthesis
metabolism
-
glycerol-3-phosphate acyltransferase (GPAT) is the critical enzyme that catalyzes the first step of triacylglycerol (TAG) formation, it is involved in the lipid metabolism of the diatom
-
metabolism
-
the enzyme contributes to triacylglycerol biosynthesis, lipid droplet formation, and host invasion in Metarhizium robertsii
-
metabolism
-
glycerol-3-phosphate acyltransferase (GPAT) is the first acyl esterifying enzyme in phosphatidylglycerol (PG) synthesis process
-
metabolism
-
enzyme GPAT is involved in the glycerolipid synthesis, it is the first and rate-limiting enzyme of the pathway. Glycerolipid synthesis and GPAT3/GPAT4 activity are induced during macrophage activation. Macrophage activation stimulates lipid droplet formation and increases triacylglycerol and phospholipid content, after Kdo2-lipid A (KLA) activation
-
metabolism
-
the enzyme catalyzes the initial step of glycerophospholipid biosynthesis in the mycobacterial cell, pathway overview
-
metabolism
-
the enzyme catalyzes the initial step of glycerophospholipid biosynthesis in the mycobacterial cell, pathway overview
-
metabolism
-
relation between three isoforms GPAT1, 3, and 4 and insulin resistance, overview. GPAT3 and GPAT4 enzyme activity can be regulated by insulin upon phosphorylation at the Thr and Ser residues. Lysophosphatidic acid (LPA) produced by GPAT4 can stimulate mitogenic activity. LPA serves as a mitogen regulating various cellular processes, such as cell proliferation and cytoskeletal reorganization. Like mitochondrial GPAT1, GPAT4 is also associated with hepatic lipid accumulation and contributes to the development of insulin resistance
-
metabolism
-
the enzyme is involved in triacylglycerol biosynthetic pathway
-
metabolism
-
PLAT2 is a rate-limiting enzyme in docosahexaenoic acid (DHA)-rich glycerolipid synthesis in Aurantiochytrium limacinum
-
physiological function
a 60% knockdown of Gpat3 mRNA in 3T3-L1 cells with small interfering (si)RNA results in a 55% decrease in fatty acid incorporation into lysophosphatidic acid. Gpat1 mRNA levels also show a large induction during 3T3-L1 adipocyte differentiation, suggesting that this isoform also contributes to GPAT activity in adipocytes
physiological function
-
cis-acting promoter sequences for the mouse GPAT1 gene are identified: promoter 1a which includes part of the classical sequence and the downstream promoter 1b. Promoter 1a facilitates transcription of two alternative GPAT1 transcript variants, GPAT1-V1 and V2, while promoter 1b produces a third transcript variant, GPAT1-V3
physiological function
GC-1 spermatogonia cells show a marked increase in proliferation after transfection with GPAT4. Cell cycle analysis shows a decrease in the percentage of cells in the G0/G1 phase and an increase in the S phase. Thus, GPAT4 might play an important role in spermatogenesis, especially in mid-meiosis
physiological function
Gpat1 mRNA levels increase more than 20fold in mouse liver in an insulin-dependent manner by refeeding of a high-carbohydrate diet after fasting, which is associated with active hepatic lipogenesis
physiological function
Gpat3 mRNA levels in ob/ob mice are decreased by 70% in white adipose tissue and increased 2fold in liver compared with wild-type animals. Treatment of ob/ob mice with rosiglitazone, a potent peroxisome proliferator-activated receptor (PPAR)gamma agonist, increases Gpat3, but not Gpat1, mRNA in white adipose tissue, suggesting that Gpat3 is a PPARgamma target gene
physiological function
in contrast to Gpat1, Gpat2 mRNA does not increase in liver of rats refed a high-sucrose diet after fasting, suggesting less contribution of GPAT2 to diet-induced hepatic TAG synthesis
physiological function
in contrast to other GPATs, GPAT4 overexpression does not increase incorporation of exogenous fatty acids into triacylglycerol in HEK-293 and COS-7 cells, suggesting that lysophosphatidic acid and phosphatidic acid produced from the GPAT4 pathway may consist of a separate pool from that utilized for triacylglycerol synthesis
physiological function
-
overexpression Gat1p in the absence of endogenous GPATs results in elongated cells with a normal cortical edoplasmic reticulum positioned underneath the plasma membrane, while excess Gat2p results in larger and round cells with an irregular layout of membranes, with pronounced invaginations also affecting the plasma membrane morphology
physiological function
the mouse Gpat1 gene promoter region contains three sterol regulatory elements responsible for SREBP-1-mediated transactivation. Ectopic expression of SREBP-1c in 3T3-L1 adipocytes or in liver of transgenic mice dramatically increases Gpat1 mRNA
physiological function
-
treatment of primary rat adipocytes with insulin acutely affects the activity of mtGPAT1 by increasing VMAX and KM for the substrates glycerol-3-phosphate and palmitoyl-CoA
physiological function
isoform GPAT2 overexpression in CHO-K1 cells increased arachidonoyl-CoA esterification and accumulation of triacylglycerols. GPAT2 expression is linked to arachidonoyl-CoA incorporation into triacylglycerols in spermatogenic germ cells
physiological function
-
the knockout mutant causes a massive reduction in seed production. The ablation of enzyme function causes defective tapetum development with reduced endoplasmic reticulum profiles in the tapetum, which largely lead to the abortion of pollen grains and defective pollen wall formation. Pollen germination and pollen tube elongation are affected in the mutant plants. Isoforms GPAT6 and GPAT1 make joint effects on the release of microspores from tetrads and stamen filament elongation
physiological function
upon stable overexpression of isoform Gpat1, lysophosphatidic acid levels in CHO-GPAT1 cells are 6fold higher than in wild-type CHO cells, and the mRNA abundance of CD36, a target of peroxisome proliferator activated receptor PPARgamma, is 2fold higher. PPARgamma activity is higher in the cells that overexpress isoform GPAT1. PPARgamma activity is further enhanced in CHO-GPAT1 cells treated with the PPARgamma ligand troglitazone. Extracellular LPA, phosphatidic acid or a membrane-permeable diacylglycerol have no effect
physiological function
yeast strains lacking isoform Gat1p are sensitive to oleate and fail to accumulate lipid particles induced by this unsaturated fatty acid
physiological function
isoform GPAT1-/- hepatocytes are not able to incorporate de novo synthesized fatty acid into triacylglycerol but oxidize twice as much exogenous fatty acid as controls. The hepatic content of long-chain acylcarnitine in fasted Gpat1-/- mice is 3-fold higher than in controls. When compared with control and isoform Gpat-/- mice, after the fasting-refeeding protocol, Gpat1-/- hepatic triacylglycerol is depleted, and long-chain acylcarnitine content is 3.5fold higher
physiological function
-
the enzyme is essential for the response to the increased metabolic demands associated with T cell activation
physiological function
-
the enzyme is required for full virulence in Metarhizium robertsii
physiological function
-
the enzyme is required for PBAN-induced sex pheromone biosynthesis and subsequent mating behavior in Bombyx mori
physiological function
the enzyme isoform GPAT-9 plays a role in essential membrane lipid synthesis. The enzyme is responsible for plant membrane lipid and oil biosynthesis
physiological function
the metabolic rate of Gpat4-/- mice fed a 45% fat diet is 12% higher than controls, and core body temperature is 1ºC higher. A 45% fat diet increases the Gpat4-/- brown adipose tissue expression of peroxisome proliferator-activated receptor alpha target genes, Cpt1alpha, Pgc1alpha, and Ucp1, and brown adipose tissue mitochondria oxidize oleate and pyruvate at higher rates than controls. Gpat4-/- neonatal brown adipose tissue preadipocytes differentiated to adipocytes incorporate 33% less fatty acid into triacylglycerol and 46% more into the pathway of beta-oxidation
physiological function
a role for GPAT4 in suppressing inflammatory responses. GPAT4 is required for enhanced glycerolipid synthesis in activated macrophages
physiological function
enzyme GPAT9 has a role for GPAT9 in seed oil biosynthesis and contributes to the biosynthesis of both polar lipids and triacylglycerol (TAG) in developing leaves, as well as lipid droplet production in developing pollen grains. GPAT9 exhibits sn-1 acyltransferase activity with high specificity for acyl-coenzyme A, thus providing further evidence that this GPAT is involved in storage lipid biosynthesis
physiological function
enzyme MS33 (SA1) may play an essential role in anther cuticle and pollen grain/microspore development by affecting lipid polyester biosynthesis in maize. MS33 affects the expression of genes involved in wax and cutin biosynthesis
physiological function
glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step of the glycerophospholipid biosynthetic pathway that synthesizes the lipid precursors for triacylglycerol biosynthesis. GPAT catalyzes the acylation of glycerol-3-phosphate to form lysophosphatidic acid. Role of GPAT in dormancy-associated triacylglycerol synthesis in Mycobacterium tuberculosis
physiological function
glycerol-3-phosphate acyltransferase 3 (OsGPAT3) is required for male fertility in rice. The endoplasmic reticulum-localized isozyme plays an indispensable role in anther development and pollen formation in rice. OsGPAT3 is essential for the timely differentiation and degradation of the tapetum
physiological function
glycerol-3-phosphate acyltransferase 9 (GPAT9), which catalyzes the synthesis of lysophosphatidic acid (LPA) from a glycerol-3-phosphate and acyl-CoA, is isolated from the moss Physcomitrella patens, which produces high levels of very-long-chain polyunsaturated fatty acids (PUFAs) in protonema and gametophores
physiological function
glycerol-3-phosphate acyltransferases (GPAT) catalyze the first and rate-limiting step in the de novo glycerolipid synthesis. Glycerol-3-phosphate acyltransferase 2 is essential for normal spermatogenesis. GPAT is regulated by epigenetic mechanisms in combination with vitamin A derivatives, analysis of GPAT2 role in the developing male germ cells, overview. GPAT2 protein is necessary for the normal development of male gonocytes. GPAT2 is necessary to reach or to complete the pachytene stage in which GPAT2 interacts with MILI to synthesize piRNAs by the primary pathway
physiological function
GPAT1 dictates fatty acid composition at the level of AGPATs or by acyl-chain remodeling by lysophospholipid acyltransferases (LPLATs). GPAT1 determines the metabolic fate of exogenous fatty acids
physiological function
GPAT1 dictates fatty acid composition at the level of AGPATs or by acyl-chain remodeling by lysophospholipid acyltransferases (LPLATs). GPAT1 determines the metabolic fate of exogenous fatty acids
physiological function
GPAT3 is required for enhanced glycerolipid synthesis in activated macrophages
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. GPAT1 preferentially catalyzes saturated fatty acids (FAs) (palmitate or C16:0) and selectively transfers acyl-CoA to the sn-1 position of glycerol 3-phosphate. Subsequently, lysophosphatidic acid, phosphatidic acid, and diacylglycerol are produced in the glycerophospholipid pathway. Mitochondrial isozyme GPAT1 activity has a huge impact on the regulation of TAG synthesis, is responsible for 30-50% of the total GPAT activity in the liver and approximately 30% of the total activity in the heart. GPAT1 is regulated at the transcriptional and posttranscriptional levels, and is highly expressed in adipose tissues and liver cells. Mitochondrial GPAT1 is a critical regulator of triacylglycerol metabolism and systemic energy homeostasis
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. GPAT2 is a murine MILI (mouse Piwi-like)-binding protein and is also involved in the primary biosynthesis of piRNA, which interacts with PIWI. GPAT2 expression is unchanged in fasted or fasted-refed rodents, further implying that GPAT2 is unrelated to triacylglycerol synthesis or energy storage in the liver, and its transcription might not be under the regulation of SREBP1 or ChREBP. GPAT2 may play an important role in the regulation of reproductive system
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. GPAT3 play a crucial role in lipid formation. GPAT3 plays a critical role in regulating glucose, energy, and lipid homeostasis
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. GPAT4 is a positive regulator of body weight
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. GPAT4 plays a unique role in triacylglycerol synthesis and maintains systemic energy balance during lactation in inguinal adipose tissue. GPAT4 is a positive regulator of body weight. GPAT4 plays a critical role in triacylglycerol synthesis during development
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. Isozyme GPAT2 is highly expressed in several cancer types (such as lung, melanoma, breast, and prostate cancer) and cancer-derived human cell lines, in which GPAT2 expression is associated with histological grading of the tumor. The expression level of GPAT2 promotes the proliferation, tumorigenicity, and migration rates of breast tumor cells
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. Microsomal GPAT3 catalyzes a broad range of reactions using long-chain acyl-CoA as substrates, including saturated and unsaturated fatty acids. GPAT3 play a crucial role in lipid formation. GPAT3 serves as an enzyme, playing critical roles in dietary lipid absorption, enteric and hepatic lipid homeostasis, as well as entero-endocrine hormone production. GPAT3 plays a critical role in regulating glucose, energy, and lipid homeostasis
physiological function
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. Mitochondrial isozyme GPAT1 activity has a huge impact on the regulation of triacylglycerol synthesis, is responsible for 30-50% of the total GPAT activity in the liver and approximately 30% of the total activity in the heart. GPAT1 is regulated at the transcriptional and posttranscriptional levels, and is highly expressed in adipose tissues and liver cells. GPAT1 plays a substantial role in modulating the cytokine production and proliferation of murine T-lymphocytes. Mitochondrial GPAT1 is a critical regulator of triacylglycerol metabolism and systemic energy homeostasis
physiological function
isozyme GPAT3 is primarily involved in triglyceride (TG) storage in adipocytes. Contribution of GPATs to acyl-CoA partitioning into glycerolipid synthesis and beta-oxidation
physiological function
isozyme GPAT3 is primarily involved in triglyceride (TG) storage in adipocytes. Contribution of GPATs to acyl-CoA partitioning into glycerolipid synthesis and beta-oxidation, overview
physiological function
isozyme GPAT4 is a primary contributor to lysophosphatidic acid synthesis in liver and brown adipose tissue. Contribution of GPATs to acyl-CoA partitioning into glycerolipid synthesis and beta-oxidation
physiological function
isozyme GPAT4 is a primary contributor to lysophosphatidic acid synthesis in liver and brown adipose tissue. Contribution of GPATs to acyl-CoA partitioning into glycerolipid synthesis and beta-oxidation. GPAT4 expression and high-fat diet-induced insulin resistance are linked to altered levels of palmitate-enriched phosphatidic acid and diacylglycerol and altered mTORC2
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids in leaves, pollen, and seeds
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids. Isozyme GPAT1 plays a role in cutin biosynthesis, dephosphorylation, and pollen sperm cell differentiation
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids. Isozyme GPAT2 plays a role in cutin biosynthesis and dephosphorylation
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids. Isozyme GPAT3 plays a role in cutin biosynthesis, dephosphorylation, and other metabolic processes
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids. Isozyme GPAT5 plays a role in root and seed coat suberin synthesis
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids. Isozyme GPAT7 plays a role in suberin biosynthesis as a response to wounding in aerial tissues
physiological function
plant sn-glycerol-3-phosphate acyltransferases are biocatalysts involved in the biosynthesis of intracellular and extracellular lipids. Isozyme GPAT8 plays a role in cutin biosynthesis (functionally redundant with GPAT4)
physiological function
-
Suaeda salsa enzyme GPAT (SsGPAT) is involved in the plant's resistance to salt stress. Salt stress is known to inhibit photosynthesis through the process of photoinhibition. SsGPAT alleviates the photoinhibition of PSII and PSI under salt stress by improving the unsaturated fatty acid content of phosphatidylglycerol (PG). The enzyme transfers the acyl moiety from an acyl-coenzyme A (CoA) donor (or acyl-acyl carrier protein [ACP] in plastids) to the sn-1 position of a glycerol-3-phosphate (G3P) molecule, yielding 1-acylglycerol-3-phosphate (or lysophosphatidic acid, LPA)
physiological function
the biosynthesis of ester glycerolipids initiates with the stepwise addition of fatty acyl groups to glycerol-3-phosphate (G3P). The first fatty acyl group is added at the sn-1 position by a G3P acyltransferase (GPAT) to give 1-acyl-G3P or lysophosphatidic acid (LPA), while the second fatty acyl group is added to the sn-2 position by a 1-acyl-G3P acyltransferase to give phosphatidic acid (PA). The glycerol-3-phosphate acyltransferase TbGAT is dispensable for viability and the biosynthesis of glycerolipids, i.e. phosphatidylcholine, phosphatidylinositol, phosphatidylserine, and GPI-anchored protein procyclin, in Trypanosoma brucei. Recombinant TbGAT restores glycerol-3-phosphate acyltransferase activity when expressed in a Leishmania major deletion strain lacking this activity and exhibits preference for medium length, unsaturated fatty acyl-CoAs. Gene TbGAT encodes a GPAT enzyme with broad fatty acyl-CoA specificity but preference for oleoyl-CoA
physiological function
the enzyme transfers the acyl moiety from an acyl-coenzyme A (CoA) donor (or acyl-acyl carrier protein [ACP] in plastids) to the sn-1 position of a glycerol-3-phosphate (G3P) molecule, yielding 1-acylglycerol-3-phosphate (or lysophosphatidic acid, LPA)
physiological function
the glycerol-3-phosphate acyltransferase PLAT2 functions in the generation of docosahexaenoic acid (DHA)-rich glycerolipids in Aurantiochytrium limacinum strain F26-b. DHA-rich glycerolipids are produced from DHA-containing lysophosphatidic acid (LPA 22:6) as a precursor, which is generated by incorporating DHA to glycerol-3-phosphate (G3P) by phospholipid acyltransferase 2 (PLAT2)
physiological function
-
the enzyme is required for full virulence in Metarhizium robertsii
-
physiological function
-
the enzyme transfers the acyl moiety from an acyl-coenzyme A (CoA) donor (or acyl-acyl carrier protein [ACP] in plastids) to the sn-1 position of a glycerol-3-phosphate (G3P) molecule, yielding 1-acylglycerol-3-phosphate (or lysophosphatidic acid, LPA)
-
physiological function
-
GPAT3 is required for enhanced glycerolipid synthesis in activated macrophages
-
physiological function
-
a role for GPAT4 in suppressing inflammatory responses. GPAT4 is required for enhanced glycerolipid synthesis in activated macrophages
-
physiological function
-
glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step of the glycerophospholipid biosynthetic pathway that synthesizes the lipid precursors for triacylglycerol biosynthesis. GPAT catalyzes the acylation of glycerol-3-phosphate to form lysophosphatidic acid. Role of GPAT in dormancy-associated triacylglycerol synthesis in Mycobacterium tuberculosis
-
physiological function
-
glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step of the glycerophospholipid biosynthetic pathway that synthesizes the lipid precursors for triacylglycerol biosynthesis. GPAT catalyzes the acylation of glycerol-3-phosphate to form lysophosphatidic acid. Role of GPAT in dormancy-associated triacylglycerol synthesis in Mycobacterium tuberculosis
-
physiological function
-
GPATs play a pivotal role in the regulation of triglyceride and phospholipid synthesis. GPATs play a critical role in the development of obesity, hepatic steatosis, and insulin resistance. GPAT4 plays a unique role in triacylglycerol synthesis and maintains systemic energy balance during lactation in inguinal adipose tissue. GPAT4 is a positive regulator of body weight. GPAT4 plays a critical role in triacylglycerol synthesis during development
-
physiological function
-
the glycerol-3-phosphate acyltransferase PLAT2 functions in the generation of docosahexaenoic acid (DHA)-rich glycerolipids in Aurantiochytrium limacinum strain F26-b. DHA-rich glycerolipids are produced from DHA-containing lysophosphatidic acid (LPA 22:6) as a precursor, which is generated by incorporating DHA to glycerol-3-phosphate (G3P) by phospholipid acyltransferase 2 (PLAT2)
-
physiological function
-
the biosynthesis of ester glycerolipids initiates with the stepwise addition of fatty acyl groups to glycerol-3-phosphate (G3P). The first fatty acyl group is added at the sn-1 position by a G3P acyltransferase (GPAT) to give 1-acyl-G3P or lysophosphatidic acid (LPA), while the second fatty acyl group is added to the sn-2 position by a 1-acyl-G3P acyltransferase to give phosphatidic acid (PA). The glycerol-3-phosphate acyltransferase TbGAT is dispensable for viability and the biosynthesis of glycerolipids, i.e. phosphatidylcholine, phosphatidylinositol, phosphatidylserine, and GPI-anchored protein procyclin, in Trypanosoma brucei. Recombinant TbGAT restores glycerol-3-phosphate acyltransferase activity when expressed in a Leishmania major deletion strain lacking this activity and exhibits preference for medium length, unsaturated fatty acyl-CoAs. Gene TbGAT encodes a GPAT enzyme with broad fatty acyl-CoA specificity but preference for oleoyl-CoA
-
additional information
identification and quantification of lipid metabolites in wild-type and mutant strains
additional information
-
identification and quantification of lipid metabolites in wild-type and mutant strains
additional information
the enzyme sequence contains four acyltransferase motifs, sequence comparisons, overview
additional information
-
the enzyme sequence contains four acyltransferase motifs, sequence comparisons, overview
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P)
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P). GPAT3 probably contains two transmembrane domains, and the active site of GPAT3 is located in the N-terminal domain
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P). GPAT3 probably contains two transmembrane domains, and the active site of GPAT3 is located in the N-terminal domain
additional information
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g., G3P). GPAT3 probably contains two transmembrane domains, and the active site of GPAT3 is located in the N-terminal domain
additional information
the GPAT/AGPAT family acyltransferases contain four wellconserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P). GPAT4 possesses a series of membrane insertion helices which form hairpin loops in the membrane or monolayer. The active acyltransferase domain is located close to the C-terminus
additional information
the GPAT/AGPAT family acyltransferases contain four wellconserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P). GPAT4 possesses a series of membrane insertion helices which form hairpin loops in the membrane or monolayer. The active acyltransferase domain is located close to the C-terminus
additional information
the GPAT/AGPAT family acyltransferases contain four wellconserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P). GPAT4 possesses a series of membrane insertion helices which form hairpin loops in the membrane or monolayer. The active acyltransferase domain is located close to the C-terminus
additional information
the N-terminal domain of GPAT2 associates with the active site, which possesses the maximum homology to that of GPAT1. The GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P). The motif IV of GPAT2 is restricted to the mitochondrial membrane, but the remaining acyltransferase motifs are exposed to the cytoplasmic side of the mitochondria
additional information
the N-terminal domain of GPAT2 associates with the active site, which possesses the maximum homology to that of GPAT1. The GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P). The motif IV of GPAT2 is restricted to the mitochondrial membrane, but the remaining acyltransferase motifs are exposed to the cytoplasmic side of the mitochondria
additional information
the N-terminal domain of GPAT2 associates with the active site, which possesses the maximum homology to that of GPAT1. The GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P). The motif IV of GPAT2 is restricted to the mitochondrial membrane, but the remaining acyltransferase motifs are exposed to the cytoplasmic side of the mitochondria
additional information
-
identification and quantification of lipid metabolites in wild-type and mutant strains
-
additional information
-
the GPAT/AGPAT family acyltransferases contain four well-conserved domains (motif I-IV), which catalyze the transferase reaction and are involved in binding to the substrate (acyl acceptor, e.g. G3P)
-
additional information
-
the enzyme sequence contains four acyltransferase motifs, sequence comparisons, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.