Any feedback?
Information on EC 1.14.17.1 - dopamine beta-monooxygenase
for references in articles please use BRENDA:EC1.14.17.1Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.14.17.1 dopamine beta-monooxygenaseIUBMB Comments
A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.
Specify your search results
Word Map
- 1.14.17.1
- catecholamine
-
noradrenergic
- norepinephrine
- nerve
-
sympathetic
- noradrenaline
- adrenal
-
innervation
- medulla
- fiber
-
dopaminergic
-
neuropeptide
-
chromaffin
-
adrenergic
-
monoamine
-
neurotransmitter
- ganglia
- coeruleus
- hypothalamus
-
catecholaminergic
- phenylethanolamine
- npy
- epinephrine
-
cholinergic
- adrenaline
-
phenylethanolamine-n-methyltransferase
- n-methyltransferase
-
varicosity
-
vasoactive
-
rostrally
- reserpine
-
gene-related
-
catecholamine-synthesizing
- disulfiram
- peptidylglycine
-
preganglionic
-
adrenomedullary
-
th-immunoreactive
-
orthostatic
-
preoptic
-
ventrolateral
-
monoaminergic
-
parabrachial
- saporin
-
intermediolateral
-
hydroxylase-immunoreactive
-
cytoarchitectonic
- medicine
- drug development
- postrema
- diagnostics
-
histofluorescence
- alpha-methyl-p-tyrosine
The enzyme appears in viruses and cellular organisms
Synonyms
dopamine-beta-hydroxylase, dopamine beta-hydroxylase, dbetah, dopamine beta hydroxylase, dopamine beta-monooxygenase, dopamine-beta-monooxygenase, plasma dopamine beta-hydroxylase, dbetam, dopamine-b-hydroxylase, plasma dbetah activity, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3,4-dihydroxy-phenylethylamine, ascorbate: oxygen oxidoreductase (3-hydroxylating)
-
-
3,4-dihydroxyphenethylamine beta-oxidase
-
-
-
-
3,4-dihydroxyphenylethylamine beta-hydoxylase
-
-
-
-
4-(2-aminoethyl)pyrocatechol beta-oxidase
-
-
-
-
DbetaH
DBH
DBM
Dopa beta-hydroxylase
-
-
-
-
dopamine beta-hydrolase
-
-
-
-
dopamine beta-hydroxylase
dopamine beta-mono-oxygenase
dopamine beta-oxidase
-
-
-
-
dopamine hydroxylase
-
-
-
-
dopamine(3,4-dihydroxyphenethylamine)beta-mono-oxygenase
-
-
-
-
dopamine-beta-hydroxylase
EC 1.14.2.1
-
-
formerly
-
oxygenase, dopamine beta-mono-
-
-
-
-
phenylamine beta-hydroxylase
-
-
-
-
dopamine beta-hydroxylase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
-
-
-
-
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
mechanism
-
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
stoichiometry
-
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
ping pong mechanism
-
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
uni-uni bi-uni ping pong mechanism
-
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
new mechanism of enzyme
-
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
during the reaction, an O atom from molecular O2 is inserted at the beta-carbon in dopamine with retention of configuration, and the second O atom goes to water. The reaction also requires two electrons provided by two ascorbate molecules that are oxidized to semihydroascorbate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9013-38-1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-(4-hydroxybenzyl)imidazole + ascorbate + O2
4-hydroxybenzaldehyde + dehydroascorbate + H2O + ?
-
-
-
?
1-phenyl-1-aminomethylethene + ascorbate + O2
2,3-dihydroxy-2-phenylpropylamine + dehydroascorbate + H2O + ?
-
ascorbate and ferrocyanide can function as a electron donors
-
?
2-aminoindane + ascorbate + O2
trans-(1S,2S)-2-amino-1-indanol + H2O
-
Stereochemistry is in contrast to the stereochemical course of pro-R hydroxylation of the DBH/phenethylamine reaction. Studies with stereospecifically deuterium labelled substrate show that the production of (1S)-aminoindanol ir the result of sterospecific pro-S hydrogen abstraction followed by the oxygen binding with overall retention of configuration
-
?
2-bromo-3-(p-hydroxyphenyl)-1-propene + ascorbate + O2
2-bromo-3-hydroxy-3-(p-hydroxyphenyl)-1-propene + H2O
-
-
-
?
2-chlorophenethylamine + ascorbate + O2
2-amino-1-chloro-1-phenylethanol + dehydroascorbate + H2O
-
-
-
?
2-hydroxyphenethylamine + ascorbate + O2
2-amino-1-phenylethane-1,1-diol + dehydroascorbate + H2O
-
-
-
?
4-hydroxybenzyl cyanide + ascorbate + O2
4-hydroxymandelonitrile + dehydroascorbate + H2O
-
and benzyl cyanide analogs
-
?
4-hydroxyphenyl-2-aminoethyl sulfide + ascorbate + O2
4-hydroxyphenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
-
-
?
4-hydroxyphenyl-2-aminopropyl selenide + ascorbate + O2
4-hydroxyphenyl-2-aminopropyl selenoxide + dehydroascorbate + H2O
-
-
-
?
beta,beta-dideuterated tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
dopamine + ascorbate + O2
norepinephrine + dehydroascorbate + H2O
-
-
-
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
tyramine + ascorbate + N,N,N',N'-tetramethyl-p-phenylenediamine
octopamine + dehydroascorbate + ?
-
-
-
-
?
tyramine + ascorbate + N,N-dimethyl-p-phenylenediamine
octopamine + dehydroascorbate + ?
-
-
-
-
?
tyramine + N-(4-chlorophenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-chlorophenyl)urea + (4-chlorophenyl)cyanamide + 1-oxo-2-(4-chlorophenyl)guanidine + H2O
-
-
-
-
?
tyramine + N-(4-isopropylphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-isopropylphenyl)urea + (4-isopropylphenyl)cyanamide + 1-oxo-2-(4-isopropylphenyl)guanidine + H2O
-
33% of the activity with N-(4-methoxyphenyl)-N-hydroxyguanidine
-
-
?
tyramine + N-(4-methoxyphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-methoxyphenyl)urea + (4-methoxyphenyl)cyanamide + 1-oxo-2-(4-methoxyphenyl)guanidine + H2O
-
-
-
-
?
tyramine + N-(4-methylphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-methylphenyl)urea + (4-methylphenyl)cyanamide + 1-oxo-2-(4-methylphenyl)guanidine + H2O
-
116% of the activity with N-(4-methoxyphenyl)-N-hydroxyguanidine
-
-
?
tyramine + N-(4-trifluoromethylphenyl)-N'-hydroxyguanidine + O2
octopamine + 1-(4-trifluoromethylphenyl)urea + (4-trifluoromethylphenyl)cyanamide + 1-oxo-2-(4-trifluoromethylphenyl)guanidine + H2O
-
16% of the activity with N-(4-methoxyphenyl)-N-hydroxyguanidine
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
N,N-dimethyl-1,4-phenylenediamine and ascorbic acid derivates are efficient reductants for the enzyme
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
ferrocyanide can function as a electron donor
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
D-xyloascorbic acid, L-araboascorbic acid or D-araboascorbic acid can replace L-xyloascorbic acid
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
3,4-dihydroxyphenethylamine is identical with 4-(2-aminoethyl)-1,2-benzendiol i.e. dopamine, ferricyanide can replace ascorbate
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
norepinephrine
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
-
-
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
and derivates
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
tyramine + ascorbate + O2
octopamine + dehydroascorbate + H2O
-
-
-
-
?
additional information
?
-
-
evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 positively regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, interaction between the two transcription factors GATA-3 and Sp1, overview
-
-
?
additional information
?
-
-
a significantly lower plasma DBH activity is found in combat veterans with posttraumatic stress disorder carrying the CC genotype as compared to veterans without posttraumatic stress disorder carrying the corresponding genotype, dependent on the genotype the regulation of DBH expression is different in response to trauma, overview
-
-
?
additional information
?
-
-
the plasma dopamine beta-hydroxylase activity is correlated with polymorphisms in the DBH gene in Eastern Indian population, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 positively regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
a noradrenalin-synthesizing enzyme from dopamine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dopamine + ascorbate + O2
norepinephrine + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
enzyme plays a key role in the biosynthetic interconversion of neurotransmitters
-
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
dopamine + ascorbate + O2
noradrenaline + dehydroascorbate + H2O
-
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
additional information
?
-
-
a significantly lower plasma DBH activity is found in combat veterans with posttraumatic stress disorder carrying the CC genotype as compared to veterans without posttraumatic stress disorder carrying the corresponding genotype, dependent on the genotype the regulation of DBH expression is different in response to trauma, overview
-
-
?
additional information
?
-
-
the plasma dopamine beta-hydroxylase activity is correlated with polymorphisms in the DBH gene in Eastern Indian population, overview
-
-
?
additional information
?
-
-
the zinc finger transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase, protein-protein interaction analyses both in vitro and in vivo, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ascorbate
DBH is an ascorbate-dependent glycoprotein that requires two type 2 bound copper ions per subunit to be active
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cu2+
Mg2+
-
regulates the translation of enzyme and affects the ratio of the two glycosylated forms of the enzyme
additional information
Cu2+
-
2,6-dimethylphenyl isocyanide as the isocyanide ligand demonstrated, first: the formation of a mono-DIMPI-four-coordinate complex at each copper, second: the formation of complexes containing more than one isocyanide per copper
Cu2+
-
1.1 Cu2+/subunit, increasing stimulation of activity by addition of up to 1 Cu2+/subunit, further additions up to at least 4 Cu/subunit gave neither stimulation nor inhibition
Cu2+
-
enzyme contains a constant amount of Cu2+, 2 mol per mol of protein, and a variable amount of Cu2+, copper content is a linear function of the purity of the enzyme
Cu2+
-
tyramine can bind to either the Cu(I) or Cu(II) forms of TbetaM
Cu2+
-
enzyme not activated by exogenous copper but activity decreases at high concentrations