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(R,S)-S-adenosyl-L-methionine + L-homocysteine
L-methionine + S-adenosyl-L-homocysteine
(S,S)-S-adenosyl-L-methionine + L-homocysteine
L-methionine + S-adenosyl-L-homocysteine
-
Substrates: higher affinity for R,S form
Products: -
?
betaine + L-homocysteine
dimethylglycine + L-methionine
Substrates: -
Products: -
?
S-adenosyl-D-methionine + L-homocysteine
?
S-adenosyl-L-ethionine + L-homocysteine
S-adenosyl-L-homocysteine + L-ethionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + D-homocysteine
?
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + DL-cysteine
S-adenosyl-L-homocysteine + S-methyl-DL-cysteine
Substrates: -
Products: -
?
S-adenosyl-L-methionine + DL-homocysteine
L-methionine + S-adenosyl-L-homocysteine
Substrates: -
Products: -
?
S-adenosyl-L-methionine + DL-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-DL-selenocysteine
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-cysteine
S-adenosyl-L-homocysteine + S-methyl-L-cysteine
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
?
-
Substrates: low activity
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
S-adenosyl-L-methionine + L-homocysteine thiolactone
?
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
Substrates: -
Products: -
?
S-methyl-L-methionine + L-cysteine
?
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
S-methyl-L-methionine + L-homocysteine
?
S-methyl-L-methionine + L-homocysteine
L-methionine
S-methyl-L-methionine + selenohomocysteine
?
Substrates: -
Products: -
?
additional information
?
-
(R,S)-S-adenosyl-L-methionine + L-homocysteine
L-methionine + S-adenosyl-L-homocysteine
-
Substrates: -
Products: (R,S)-S-adenosyl-L-methionine is preferred over (S,S)-S-adenosyl-L-methionine
?
(R,S)-S-adenosyl-L-methionine + L-homocysteine
L-methionine + S-adenosyl-L-homocysteine
-
Substrates: -
Products: -
?
S-adenosyl-D-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-adenosyl-D-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-adenosyl-D-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-adenosyl-D-methionine + L-homocysteine
?
-
Substrates: low activity
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
Substrates: the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
Substrates: the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
Substrates: the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: enzymic preference of the pro-(R)-methyl group to the extent of 94% or more
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: biosynthesis of methionine
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: biosynthesis of methionine
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: synthesis of L-methionine from homocysteine
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: high homology to betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5), betaine is not a substrate for BHMT-2 but high activity with S-methyl-L-methionine
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
?
-
Substrates: S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine
Products: -
?
S-methyl-L-methionine + L-homocysteine
L-methionine
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
L-methionine
Substrates: metabolism of S-methylmethionine requires a functional YagD protein, since inactivation of the yagD gene abolishes the capacity to grow on S-methylmethionine
Products: -
?
additional information
?
-
Substrates: no activity with D-cysteine, L-cysteine, DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
Products: -
?
additional information
?
-
Substrates: no activity with D-cysteine, L-cysteine, DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
Products: -
?
additional information
?
-
Substrates: no activity with DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
Products: -
?
additional information
?
-
Substrates: no activity with DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
Products: -
?
additional information
?
-
Substrates: the enzyme also catalyzes the reaction of selenocysteine methyltransferase
Products: -
?
additional information
?
-
-
Substrates: the enzyme also catalyzes the reaction of selenocysteine methyltransferase
Products: -
?
additional information
?
-
-
Substrates: no substrate: S-ribosyl-L-methionine
Products: -
?
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S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
S-methyl-L-methionine + L-homocysteine
2 L-methionine
S-methyl-L-methionine + L-homocysteine
L-methionine
Substrates: metabolism of S-methylmethionine requires a functional YagD protein, since inactivation of the yagD gene abolishes the capacity to grow on S-methylmethionine
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
Substrates: the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: biosynthesis of methionine
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: biosynthesis of methionine
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
-
Substrates: -
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: synthesis of L-methionine from homocysteine
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
Products: -
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
Substrates: -
Products: -
?
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Balish, E.; Shapiro, S.K.
Methionine biosynthesis in Escherichia coli: induction and repression of methylmethionine(or adenosylmethionine):homocysteine methyltransferase
Arch. Biochem. Biophys.
119
62-68
1967
Escherichia coli, Escherichia coli Texas M
brenda
Shapiro, S.K.
Adenosylmethionine-homocysteine transmethylase
Biochim. Biophys. Acta
29
405-409
1958
Cyberlindnera jadinii, Equus caballus, Escherichia coli, Klebsiella aerogenes, Klebsiella aerogenes NRRL 199, Saccharomyces cerevisiae
brenda
Shapiro, S.K.; Yphantis, D.A.
Assay of S-methylmethionine and S-adenosylmethionine homocysteine transmethylases
Biochim. Biophys. Acta
36
241-244
1959
Klebsiella aerogenes, Saccharomyces cerevisiae, Escherichia coli, Rattus norvegicus
brenda
Shapiro, S.K.
S-Adenosylmethionine:L-homocysteine S-methyltransferase (Saccharomyces cerevisiae)
Methods Enzymol.
17B
400-405
1971
Klebsiella aerogenes, Saccharomyces cerevisiae, Rattus norvegicus
-
brenda
Nakamura, K.D.; Schlenk, F.
The activity of adenosyl-D-methionine and adenosyl-2-methylmethionine in transmethylations
Arch. Biochem. Biophys.
177
170-175
1976
Saccharomyces cerevisiae
brenda
Ranocha, P.; Bourgis, F.; Ziemak, M.J.; Rhodes, D.; Gage, D.A.; Hanson, A.D.
Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis
J. Biol. Chem.
275
15962-15968
2000
Arabidopsis thaliana (Q9M1W4), Arabidopsis thaliana (Q9SDL7)
brenda
Thomas, D.; Becker, A.; Surdin-Kerjan, Y.
Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells
J. Biol. Chem.
275
40718-40724
2000
Saccharomyces cerevisiae
brenda
Matsuyama, N.; Yamaguchi, M.; Toyosato, M.; Takayama, M.; Mizuno, K.
New enzymatic colorimetric assay for total homocysteine
Clin. Chem.
47
2155-2157
2001
Saccharomyces cerevisiae
brenda
Mudd, S.H.; Datko, A.H.
The S-methylmethionine cycle in Lemna paucicostata
Plant Physiol.
93
623-630
1990
Lemna aequinoctialis
brenda
Lyi, S.M.; Zhou, X.; Kochian, L.V.; Li, L.
Biochemical and molecular characterization of the homocysteine S-methyltransferase from broccoli (Brassica oleracea var. italica)
Phytochemistry
68
1112-1119
2007
Brassica oleracea (A4ZGQ8)
brenda
Szegedi, S.S.; Castro, C.C.; Koutmos, M.; Garrow, T.A.
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase
J. Biol. Chem.
283
8939-8945
2008
Homo sapiens
brenda
Thanbichler, M.; Neuhierl, B.; Bck A.
S-Methylmethionine metabolism in Escherichia coli
J. Bacteriol.
181
662-665
1999
Escherichia coli (Q47690), Escherichia coli
brenda
Neuhierl, B.; Thanbichler, M.; Lottspeich, F.; Bck, A.
A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation
J. Biol. Chem.
274
5407-5414
1999
Escherichia coli (Q47690), Escherichia coli
brenda
Grue-Sorensen, G.; Kelstrup, E.; Kjaer, A.; Madsen, J.O.
Diastereospecific, enzymically catalysed transmethylation from S-methyl-L-Lmethionine to L-homocysteine, a naturally occurring process
J. Chem. Soc. Perkin Trans. I
1984
1091-1097
1989
Canavalia ensiformis
-
brenda
Ranocha, P.; McNeil, S.D.; Ziemak, M.J.; Li, C.; Tarczynski, M.C.; Hanson, A.D.
The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity
Plant J.
25
575-584
2001
Arabidopsis thaliana (Q8LAX0)
brenda
Vinci, C.R.; Clarke, S.G.
Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae
J. Biol. Chem.
285
20526-20531
2010
Saccharomyces cerevisiae
brenda
Bradbury, L.M.; Ziemak, M.J.; El Badawi-Sidhu, M.; Fiehn, O.; Hanson, A.D.
Plant-driven repurposing of the ancient S-adenosylmethionine repair enzyme homocysteine S-ethyltransferase
Biochem. J.
463
279-286
2014
Escherichia coli
brenda
Li, K.; Li, G.; Bradbury, L.M.; Hanson, A.D.; Bruner, S.D.
Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli
Biochem. J.
473
277-284
2015
Escherichia coli (Q47690), Escherichia coli
brenda
Perez-Miguelsanz, J.; Vallecillo, N.; Garrido, F.; Reytor, E.; Perez-Sala, D.; Pajares, M.A.
Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle
Biochim. Biophys. Acta
1864
1165-1182
2017
Rattus norvegicus (O09171)
brenda
Wu, L.; Shang, Y.; Liu, T.; Chen, W.; Liu, B.; Zhang, L.; Liu, D.; Zhang, B.; Zhang, H.
Characterization of a selenium-resistance-enhancing homocysteine s-methyltransferase from Aegilops tauschii
Cereal Res. Commun.
46
263-274
2018
Aegilops tauschii (M8C0H7)
-
brenda