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2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
2 glutathione + H2O2
glutathione disulfide + 2 H2O
-
-
-
?
2 glutathione + phosphatidylcholine hydroperoxide
glutathione disulfide + ? + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + 2-methylpropan-2-ol + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
glutathione + (beta-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-gamma-palmitoyl)-L-alpha-phosphatidylcholine
?
-
-
-
-
?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-3-phosphatidylcholine
?
-
-
-
-
?
glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine
?
-
-
-
-
?
glutathione + 3beta-hydroxycholest-5-ene-7alpha-hydroperoxide
cholest-5-ene-3beta,7alpha-diol + ?
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
glutathione + cardiolipin
?
glutathione + cholesterol hydroperoxide
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
glutathione + cumene hydroperoxide
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
glutathione + fatty acid hydroperoxides
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
glutathione + LDL hydroperoxides
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
glutathione + phosphatidic acid hydroperoxide
?
-
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
glutathione + phosphatidylethanolamine hydroperoxide
?
-
-
-
-
?
glutathione + phosphatidylserine hydroperoxide
?
-
-
-
-
?
glutathione + phospholipid hydroperoxide
oxidized glutathione + phospholipid + H2O
-
-
-
-
r
glutathione + phospholipid hydroperoxides
?
glutathione + QKSPCCPKSP
?
-
-
-
?
glutathione + t-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
glutathione + tert-butyl-hydroperoxide
?
glutathione + tert-butylhydroperoxide
?
-
-
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
GSH + H2O2
GSSG + ?
-
about 50% of the activity with cumene hydroperoxide
-
-
?
GSH + linoleic acid hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + phosphatidylcholine dilinoleoyl hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
KKSQCCQQKT + H2O2
KKSQ-L-cystinyl-QQKT + 2 H2O
-
-
-
?
KPPCCPPK + H2O2
KPP-L-cystinyl-PPK + 2 H2O
-
-
-
?
PKPPCCPPKP + H2O2
PKPP-L-cystinyl-PPKP + 2 H2O
-
-
-
?
PKSPCCPPKP + H2O2
PKSP-L-cystinyl-PPKP + 2 H2O
-
-
-
?
PKSPCCPPKS + H2O2
PKSP-L-cystinyl-PPKS + 2 H2O
-
-
-
?
PPCCPP + H2O2
PP-L-cystinyl-PP + 2 H2O
-
-
-
?
PPKPCCPPKP + H2O2
PPKP-L-cystinyl-PKP + 2 H2O
-
-
-
?
PPPPCCPPPP + H2O2
PPPP-L-cystinyl-PPPP + 2 H2O
-
-
-
?
QKPPCCPKSP + H2O2
QKPP-L-cystinyl-PKSP + 2 H2O
-
-
-
?
thioredoxin + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine
?
-
-
-
-
?
additional information
?
-
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
-
-
-
?
2 glutathione + tert-butyl hydroperoxide
glutathione disulfide + tert-butyl hydroxide + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
animal
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + cardiolipin
?
-
-
-
-
?
glutathione + cardiolipin
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cholesterol hydroperoxides
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
no activity
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + cumene hydroperoxide
?
-
-
-
-
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide
?
-
and derivatives of dilinoyl phosphatidylcholine hydroperoxide
-
-
?
glutathione + H2O2
?
activity assay
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
no activity
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
protein follows a pingpong mechanism, which is similar to that of native cytosolic glutathione peroxidase, EC 1.11.1.9
-
?
glutathione + H2O2
?
-
no activity
-
-
?
glutathione + H2O2
?
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
activity assay
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + H2O2
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
L-alpha-phosphatidylcholine hydroperoxide is a specific substrate of GPx4
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
dithiothreitol, 2-mercaptoethanol, cysteine and homocysteine also serve as reducing agents
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
dithiothreitol and dithioerythritol are 3fold more active than glutathione, while 2-mercaptoethanol and L-cysteine show 50% and 20% of the activity with glutathione as reductants, respectively
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
ir
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
reduces hydroperoxides of phosphatidylcholine and cholesteryllinolate alone or associated to oxidized LDL and oxidized HDL
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
wide specificity for lipid hydroperoxides
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
the oxidized active site of the enzyme can also be reduced by mercaptoethanol
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
enzyme reduces amphiphilic peroxides, possibly at the water-lipid interface
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
activity assay
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
activity assay
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
activity assay
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
-
-
?
glutathione + phosphatidylcholine hydroperoxide
?
-
-
-
-
?
glutathione + phospholipid hydroperoxides
?
-
-
-
-
?
glutathione + phospholipid hydroperoxides
?
-
-
-
-
?
glutathione + phospholipid hydroperoxides
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
no activity
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
-
-
-
-
?
glutathione + tert-butyl-hydroperoxide
?
-
-
-
?
glutathione + tert-butyl-hydroperoxide
?
-
activity assay
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + cumene hydroperoxide
GSSG + ?
-
-
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
-
about 80% of the activity with cumene hydroperoxide
-
-
?
GSH + tert-butyl hydroperoxide
GSSG + ?
-
-
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
in addition to a structural role, PHGPx may also be involved in the non-enzymatic protection of sperm surface against detrimental effects caused by accumulation of modified lipids
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase are counterparts in the metabolism of hydroperoxy lipids
-
-
?
additional information
?
-
-
enzyme inhibits peroxidation of microsomes
-
-
?
additional information
?
-
-
the enzyme appears to be indispensable for structural integrity of spermatozoa and to codetermine sperm motility and viability
-
-
?
additional information
?
-
-
the enzyme plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism
-
-
?
additional information
?
-
-
GPx4 can react with H2O2 and a wide range of lipid hydroperoxides including oxidized phospholipids and cholesterol hydroperoxides
-
-
?
additional information
?
-
different isomers of the hydroperoxide hydroperoxy-octadecadienoic acid (HpODE) are formed depending on whether linoleic acid is subjected to enzymatic, free radical, or non-radical attack
-
-
-
additional information
?
-
-
tyrosine phosphorylation of the enzyme may represent an important event in the signaling cascade associated with capacitation that may impact the regulation of hyperactivation of sperm motility and/or mitochondrial function
-
-
?
additional information
?
-
-
PHGPx-/- mice are embryonically lethal at gestation day 7.5. PHGPx+/- mice cells show decreased life span after exposure to irradiation and increased susceptibility to oxidative and genotoxic stress
-
-
?
additional information
?
-
-
preferred substrates are found to be hydroperoxide groups of phosphatidylcholine and on cumene and t-butyl hydroperoxides
-
-
?
additional information
?
-
-
reduces lipid hydroperoxides in biomembranes
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
-
-
?
additional information
?
-
-
controlled by gonadotropin
-
-
?
additional information
?
-
total GPx activity is determined in a photometric NADPH-coupled assay using tert-BHP as the substrate. The decrease of NADPH absorbance is monitored at 340 nm
-
-
-
additional information
?
-
total GPx activity is determined in a photometric NADPH-coupled assay using tert-BHP as the substrate. The decrease of NADPH absorbance is monitored at 340 nm
-
-
-
additional information
?
-
-
specifically detoxifies phospholipid peroxide
-
-
?
additional information
?
-
-
the enzyme shows phospholipid hydroperoxide glutathione peroxidase activity and thioredoxin peroxidase activity. Thioredoxin peroxidase activity is higher than phospholipid hydroperoxidase activity in terms of efficiency and substrate affinities. No activity with glutathione + H2O2
-
-
?
additional information
?
-
-
reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
PhGPx prevents NF-kappaB activation, oxLDL-induced proliferation and linoleic acid-induced apoptosis
-
-
?
additional information
?
-
PHGPx is an antioxidant enzyme that can reduce peroxidized phospholipids produced in cell membranes
-
-
?
additional information
?
-
-
the enzyme is not enzymatically active but may be able to interact with modified phospholipids on the membrane, thereby masking or removing potentially damaging lipids from the surface of the parasitpoids eggs
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
additional information
?
-
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
animal
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
enzyme reduces amphiphilic peroxides, possibly at the water-lipid interface
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
in addition to a structural role, PHGPx may also be involved in the non-enzymatic protection of sperm surface against detrimental effects caused by accumulation of modified lipids
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase are counterparts in the metabolism of hydroperoxy lipids
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-
?
additional information
?
-
-
enzyme inhibits peroxidation of microsomes
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-
?
additional information
?
-
-
the enzyme appears to be indispensable for structural integrity of spermatozoa and to codetermine sperm motility and viability
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?
additional information
?
-
-
the enzyme plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism
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-
?
additional information
?
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-
tyrosine phosphorylation of the enzyme may represent an important event in the signaling cascade associated with capacitation that may impact the regulation of hyperactivation of sperm motility and/or mitochondrial function
-
-
?
additional information
?
-
-
PHGPx-/- mice are embryonically lethal at gestation day 7.5. PHGPx+/- mice cells show decreased life span after exposure to irradiation and increased susceptibility to oxidative and genotoxic stress
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
-
-
?
additional information
?
-
-
controlled by gonadotropin
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
PhGPx prevents NF-kappaB activation, oxLDL-induced proliferation and linoleic acid-induced apoptosis
-
-
?
additional information
?
-
-
the enzyme is not enzymatically active but may be able to interact with modified phospholipids on the membrane, thereby masking or removing potentially damaging lipids from the surface of the parasitpoids eggs
-
-
?
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Ursini, F.; Maiorini, M.; Gregolin, C.
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase
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Sus scrofa
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Sus scrofa
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Sus scrofa
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Sus scrofa
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Zhang, L.; Maiorini, M.; Roveri, A.; Ursini, F.
Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases
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1989
Rattus norvegicus
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Avsian-Kretchmer, O.; Eshdat, Y.; Gueta-Dahan, Y.; Ben-Hayyim, G.
Regulation of stress-induced phospholipid hydroperoxide glutathione peroxidase expression in citrus
Planta
209
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Citrus sinensis
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Saito, Y.; Hayashi, T.; Tanaka, A.; Watanabe, Y.; Suzuki, M.; Saito, E.; Takahashi, K.
Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein P
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Homo sapiens
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Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases
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Saccharomyces cerevisiae
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Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity
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352
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Trypanosoma cruzi
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Purification of phospholipid hydroperoxide glutathione peroxidase from bovine retina
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12
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Bos taurus
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Tramer, F.; Micali, F.; Sandri, G.; Bertoni, A.; Lenzi, A.; Gandini, L.; Panfili, E.
Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages
Int. J. Androl.
25
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2002
Rattus norvegicus
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Chambers, S.J.; Lambert, N.; Williamson, G.
Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity
Int. J. Biochem.
26
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1994
Homo sapiens
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Schnurr, K.; Borchert, A.; Gerth, C.; Anton, M.; Kuhn, H.
Bacterial and nonbacterial expression of wild-type and mutant human phospholipid hydroperoxide glutathione peroxidase and purification of the mutant enzyme in the milligram scale
Protein Expr. Purif.
19
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2000
Homo sapiens
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Roveri, A.; Maiorino, M.; Nisii, C.; Ursini, F.
Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes
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1994
Rattus norvegicus
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Sattler, W.; Maiorino, M.; Stocker, R.
Reduction of HDL- and LDL-associated cholesterylester and phospholipid hydroperoxides by phospholipid hydroperoxide glutathione peroxidase and ebselen (PZ 51)
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309
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Sus scrofa
brenda
Maiorino, M.; Roche, C.; Kiess, M.; Koenig, K.; Gawlik, D.; Matthes, M.; Naldini, E.; Pierce, R.; Flohe, L.
A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni
Eur. J. Biochem.
238
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1996
Schistosoma mansoni
brenda
Nomura, K.; Imai, H.; Koumura, T.; Kobayashi, T.; Nakagawa, Y.
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
Biochem. J.
351
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2000
Rattus norvegicus
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Foresta, C.; Flohe, L.; Garolla, A.; Roveri, A.; Ursini, F.; Maiorino, M.
Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase
Biol. Reprod.
67
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2002
Homo sapiens
brenda
Nagdas, S.K.; Winfrey, V.P.; Olson, G.E.
Tyrosine phosphorylation generates multiple isoforms of the mitochondrial capsule protein, phospholipid hydroperoxide glutathione peroxidase (PHGPx), during hamster sperm capacitation
Biol. Reprod.
72
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2005
Mesocricetus auratus
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Herbette, S.; Lenne, C.; Leblanc, N.; Julien, J.L.; Drevet, J.R.; Roeckel-Drevet, P.
Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activities
Eur. J. Biochem.
269
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2002
Solanum lycopersicum
brenda
Maiorino, M.; Mauri, P.; Roveri, A.; Benazzi, L.; Toppo, S.; Bosello, V.; Ursini, F.
Primary structure of the nuclear forms of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat spermatozoa
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2005
Rattus norvegicus
brenda
Tramer, F.; Caponecchia, L.; Sgro, P.; Martinelli, M.; Sandri, G.; Panfili, E.; Lenzi, A.; Gandini, L.
Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR)does not differ between normo- and hypomotile human sperm samples
Int. J. Androl.
27
88-93
2004
Homo sapiens
brenda
Utomo, A.; Jiang, X.; Furuta, S.; Yun, J.; Levin, D.S.; Wang, Y.C.; Desai, K.V.; Green, J.E.; Chen, P.L.; Lee, W.H.
Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells
J. Biol. Chem.
279
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2004
Homo sapiens
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Li, D.; Blasevich, F.; Theopold, U.; Schmidt, O.
Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases
J. Insect Physiol.
49
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2003
Drosophila melanogaster, Venturia canescens
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Diaconu, M.; Tangat, Y.; Boehm, D.; Kuehn, H.; Michelmann, H.W.; Schreiber, G.; Haidl, G.; Glander, H.J.; Engel, W.; Nayernia, K.
Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene
Andrologia
38
152-157
2006
Homo sapiens
brenda
Hattori, H.; Imai, H.; Furuhama, K.; Sato, O.; Nakagawa, Y.
Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha
Biochem. Biophys. Res. Commun.
337
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2005
Homo sapiens
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Hattori, H.; Imai, H.; Hanamoto, A.; Furuhama, K.; Nakagawa, Y.
Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophils
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389
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2005
Rattus norvegicus
brenda
Januel, C.; El Hentati, F.; Carreras, M.; Arthur, J.R.; Calzada, C.; Lagarde, M.; Vericel, E.
Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization in resting platelets, and compartmental change during platelet activation
Biochim. Biophys. Acta
1761
1228-1234
2006
Homo sapiens
brenda
Puglisi, R.; Tramer, F.; Carlomagno, G.; Gandini, L.; Panfili, E.; Stefanini, M.; Lenzi, A.; Mangia, F.; Boitani, C.
PHGPx in spermatogenesis: how many functions?
Contraception
72
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2005
Rattus norvegicus
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Lapointe, J.; Kimmins, S.; Maclaren, L.A.; Bilodeau, J.F.
Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts
Endocrinology
146
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2005
Bos taurus (Q9N2J2), Bos taurus
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Steinbrenner, H.; Bilgic, E.; Alili, L.; Sies, H.; Brenneisen, P.
Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity
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2006
Homo sapiens
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Dash, B.; Metz, R.; Huebner, H.J.; Porter, W.; Phillips, T.D.
Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris
Gene
381
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2006
Hydra vulgaris (Q072C7), Hydra vulgaris
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Schneider, M.; Vogt Weisenhorn, D.M.; Seiler, A.; Bornkamm, G.W.; Brielmeier, M.; Conrad, M.
Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase
Gene Expr. Patterns
6
489-494
2006
Mus musculus
brenda
Liu, J.; Du, J.; Zhang, Y.; Sun, W.; Smith, B.J.; Oberley, L.W.; Cullen, J.J.
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase
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17
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2006
Homo sapiens
brenda
Cossio-Bayugar, R.; Miranda, E.; Holman, P.J.
Molecular cloning of a phospholipid-hydroperoxide glutathione peroxidase gene from the tick, Boophilus microplus (Acari: Ixodidae)
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35
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2005
Rhipicephalus microplus (Q2XW19), Rhipicephalus microplus
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Imai, H.; Saito, M.; Kirai, N.; Hasegawa, J.; Konishi, K.; Hattori, H.; Nishimura, M.; Naito, S.; Nakagawa, Y.
Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase
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140
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2006
Mus musculus
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Maiorino, M.; Roveri, A.; Benazzi, L.; Bosello, V.; Mauri, P.; Toppo, S.; Tosatto, S.C.; Ursini, F.
Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidase
J. Biol. Chem.
280
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2005
Rattus norvegicus (P36970)
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Borchert, A.; Wang, C.C.; Ufer, C.; Schiebel, H.; Savaskan, N.E.; Kuhn, H.
The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis
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281
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2006
Mus musculus
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Kriska, T.; Girotti, A.W.
A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides
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827
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2005
Homo sapiens
brenda
Conrad, M.; Moreno, S.G.; Sinowatz, F.; Ursini, F.; Koelle, S.; Roveri, A.; Brielmeier, M.; Wurst, W.; Maiorino, M.; Bornkamm, G.W.
The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
Mol. Cell. Biol.
25
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2005
Mus musculus
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Yang, X.D.; Dong, C.J.; Liu, J.Y.
A plant mitochondrial phospholipid hydroperoxide glutathione peroxidase: its precise localization and higher enzymatic activity
Plant Mol. Biol.
62
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2006
Raphanus sativus
brenda
Scheerer, P.; Borchert, A.; Krauss, N.; Wessner, H.; Gerth, C.; Hoehne, W.; Kuhn, H.
Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)
Biochemistry
46
9041-9049
2007
Homo sapiens (P36969), Homo sapiens
brenda
Conrad, M.; Schneider, M.; Seiler, A.; Bornkamm, G.W.
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals
Biol. Chem.
388
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Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Wang, F.; Zhou, H.; Kong, B.; Fan, J.; Chen, H.; Liu, J.
Urea-induced inactivation and unfolding of recombinant phospholipid hydroperoxide glutathione peroxidase from Oryza sativa
Chem. Res. Chin. Univ.
23
562-566
2007
Oryza sativa
brenda
Puglisi, R.; Bevilacqua, A.; Carlomagno, G.; Lenzi, A.; Gandini, L.; Stefanini, M.; Mangia, F.; Boitani, C.
Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertility
Endocrinology
148
4302-4309
2007
Mus musculus (O70325), Mus musculus
brenda
Dabkowski, E.R.; Williamson, C.L.; Hollander, J.M.
Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunction
Free Radic. Biol. Med.
45
855-865
2008
Mus musculus, Mus musculus (O70325)
brenda
Cejas, P.; Garcia-Cabezas, M.A.; Casado, E.; Belda-Iniesta, C.; De Castro, J.; Fresno, J.A.; Sereno, M.; Barriuso, J.; Espinosa, E.; Zamora, P.; Feliu, J.; Redondo, A.; Hardisson, D.A.; Renart, J.; Gonzalez-Baron, M.
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma
Free Radic. Res.
41
681-687
2007
Homo sapiens
brenda
Cai, G.B.; Bae, Y.A.; Kim, S.H.; Sohn, W.M.; Lee, Y.S.; Jiang, M.S.; Kim, T.S.; Kong, Y.
Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis
Int. J. Parasitol.
38
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2008
Clonorchis sinensis (A0SWV9), Clonorchis sinensis (A0SWW0), Clonorchis sinensis (A0SWW1), Clonorchis sinensis (A0SWW2), Clonorchis sinensis
brenda
Wang, Z.; Wang, F.; Duan, R.; Liu, J.Y.
Purification and physicochemical characterization of a recombinant phospholipid hydroperoxide glutathione peroxidase from Oryza sativa
J. Biochem. Mol. Biol.
40
412-418
2007
Oryza sativa
brenda
Baek, I.J.; Seo, D.S.; Yon, J.M.; Lee, S.R.; Jin, Y.; Nahm, S.S.; Jeong, J.H.; Choo, Y.K.; Kang, J.K.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice
J. Mol. Histol.
38
237-244
2007
Mus musculus
brenda
Baek, I.J.; Yon, J.M.; Lee, S.R.; Jin, Y.; Kim, M.R.; Ahn, B.; Hong, J.T.; Choo, Y.K.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes
J. Vet. Sci.
8
213-218
2007
Rattus norvegicus
brenda
Ding, W.Q.; Lind, S.E.
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity
Mol. Cancer Ther.
6
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2007
Homo sapiens
brenda
Zafiriou, M.P.; Deva, R.; Ciccoli, R.; Siafaka-Kapadai, A.; Nigam, S.
Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?
Prostaglandins Leukot. Essent. Fatty Acids
77
209-215
2007
Rattus norvegicus
brenda
Dong, C.J.; Yang, X.D.; Liu, J.Y.
Enzymatic properties of a recombinant phospholipid hydroperoxide glutathione peroxidase from Momordica charantia and its complementation function in yeast
Biochemistry (Moscow)
74
502-508
2009
Momordica charantia (Q8W259), Momordica charantia
brenda
Conrad, M.
Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4
Biochim. Biophys. Acta
1790
1575-1585
2009
Mus musculus
brenda
Bae, Y.; Cai, G.; Kim, S.; Zo, Y.; Kong, Y.
Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals
BMC Evol. Biol.
9
72
2009
animal
brenda
Hu, Z.; Lee, K.S.; Choo, Y.M.; Yoon, H.J.; Kim, I.; Wei, Y.D.; Gui, Z.Z.; Zhang, G.Z.; Sohn, H.D.; Jin, B.R.
Molecular characterization of a phospholipid-hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus
Comp. Biochem. Physiol. B
155
54-61
2010
Bombus ignitus (C3VVL8), Bombus ignitus
brenda
Hermesz, E.; Ferencz, A.
Identification of two phospholipid hydroperoxide glutathione peroxidase (gpx4) genes in common carp
Comp. Biochem. Physiol. C
150
101-106
2009
Cyprinus carpio
brenda
Kadota, Y.; Suzuki, S.; Ideta, S.; Fukinbara, Y.; Kawakami, T.; Imai, H.; Nakagawa, Y.; Sato, M.
Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells
Eur. J. Pharmacol.
626
166-170
2009
Rattus norvegicus
brenda
Chen, H.; Lin, C.; Ken, C.; Wen, L.; Lin, C.
Putative phospholipid hydroperoxide glutathione peroxidase from Antrodia camphorata
Food Chem.
115
476-482
2009
Taiwanofungus camphoratus (B8K1J5)
brenda
Guo, Z.; Ran, Q.; Roberts, L.J.; Zhou, L.; Richardson, A.; Sharan, C.; Wu, D.; Yang, H.
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice
Free Radic. Biol. Med.
44
343-352
2008
Homo sapiens
brenda
Li, T.; Yang, X.; Liu, J.
Tissue and induction expression profiles of rice phospholipid hydroperoxide glutathione peroxidase at protein level
Prog. Biochem. Biophys.
36
77-82
2009
Oryza sativa
-
brenda
Kernstock, R.M.; Girotti, A.W.
New strategies for the isolation and activity determination of naturally occurring type-4 glutathione peroxidase
Protein Expr. Purif.
62
216-222
2008
Rattus norvegicus
brenda
Zhang, W.; He, Y.; Yang, Z.; Yu, J.; Chen, Y.; Zhou, C.
Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae
Proteins Struct. Funct. Genet.
73
1058-1062
2008
Saccharomyces cerevisiae
brenda
Dimastrogiovanni, D.; Anselmi, M.; Miele, A.E.; Boumis, G.; Petersson, L.; Angelucci, F.; Nola, A.D.; Brunori, M.; Bellelli, A.
Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase
Proteins
78
259-270
2009
Schistosoma mansoni
brenda
Stradaioli, G.; Sylla, L.; Monaci, M.; Maiorino, M.
Phospholipid hydroperoxide glutathione peroxidase in bull spermatozoa provides a unique marker in the quest for semen quality analysis
Theriogenology
72
91-98
2009
Bos taurus
brenda
Baseler, W.A.; Dabkowski, E.R.; Jagannathan, R.; Thapa, D.; Nichols, C.E.; Shepherd, D.L.; Croston, T.L.; Powell, M.; Razunguzwa, T.T.; Lewis, S.E.; Schnell, D.M.; Hollander, J.M.
Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
304
R553-R565
2013
Mus musculus
brenda
Han, X.; Fan, Z.; Yu, Y.; Liu, S.; Hao, Y.; Huo, R.; Wei, J.
Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase
IUBMB Life
65
951-956
2013
Homo sapiens (D6W5Y2), Homo sapiens
brenda
Janowski, R.; Scanu, S.; Niessing, D.; Madl, T.
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4
Acta Crystallogr. Sect. F
72
743-749
2016
Mus musculus (O70325), Mus musculus
brenda
Yu, Y.; Song, J.; Guo, X.; Wang, S.; Yang, X.; Chen, L.; Wei, J.
Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli
Free Radic. Biol. Med.
71
332-338
2014
Homo sapiens (P36969), Homo sapiens
brenda
Moosmayer, D.; Hilpmann, A.; Hoffmann, J.; Schnirch, L.; Zimmermann, K.; Badock, V.; Furst, L.; Eaton, J.; Viswanathan, V.; Schreiber, S.; Gradl, S.; Hillig, R.
Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162
Acta Crystallogr. D Struct. Biol.
77
237-248
2021
Homo sapiens (P36969), Homo sapiens
brenda
Ferro, D.; Bakiu, R.; Pucciarelli, S.; Miceli, C.; Vallesi, A.; Irato, P.; Santovito, G.
Molecular characterization, protein-protein interaction network, and evolution of four glutathione peroxidases from Tetrahymena thermophila
Antioxidants (Basel)
9
1-15
2020
Tetrahymena thermophila (I7LVV4), Tetrahymena thermophila SB210 (I7LVV4)
brenda
Corteselli, E.M.; Gibbs-Flournoy, E.; Simmons, S.O.; Bromberg, P.; Gold, A.; Samet, J.M.
Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4
Biochim. Biophys. Acta
1863
950-959
2019
Homo sapiens (P36969)
brenda
Kruemmel, B.; Ploetz, T.; Joerns, A.; Lenzen, S.; Mehmeti, I.
The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death
Biochim. Biophys. Acta
1867
166114
2021
Rattus norvegicus (P36970), Rattus norvegicus Lewis-1AR1 (P36970)
brenda
Borchert, A.; Kalms, J.; Roth, S.; Rademacher, M.; Schmidt, A.; Holzhutter, H.; Kuhn, H.; Scheerer, P.
Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1863
1095-1107
2018
Homo sapiens (P36969), Homo sapiens
brenda
Jelinek, A.; Heyder, L.; Daude, M.; Plessner, M.; Krippner, S.; Grosse, R.; Diederich, W.E.; Culmsee, C.
Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis
Free Radic. Biol. Med.
117
45-57
2018
Mus musculus (O70325), Mus musculus
brenda
Krehelova, A.; Kovarikova, V.; Domorakova, I.; Solar, P.; Pastornicka, A.; Pavliuk-Karachevtseva, A.; Rybarova, S.; Hodorova, I.; Mihalik, J.
Characterization of glutathione peroxidase 4 in rat oocytes, preimplantation embryos, and selected maternal tissues during early development and implantation
Int. J. Mol. Sci.
22
5174
2021
Rattus norvegicus (P36970)
brenda
Gao, S.Q.; Liu, J.Q.; Han, Y.L.; Deji, Q.Z.; Zhaba, W.D.; Deng, H.J.; Liu, X.L.; Zhou, M.L.
Neuroprotective role of glutathione peroxidase 4 in experimental subarachnoid hemorrhage models
Life Sci.
257
118050
2020
Rattus norvegicus (P36970), Rattus norvegicus Sprague-Dawley (P36970)
brenda
Wang, Z.; Zhang, P.; Shao, Y.; Xu, T.; Jia, X.; Zhang, X.; Si, W.; Jia, J.
Molecular cloning and the expression pattern of a phospholipid hydroperoxide glutathione peroxidase in Kalidium foliatum under NaCl treatment
Russ. J. Plant Physiol.
67
750-757
2020
Kalidium foliatum
-
brenda