2.3.1.291: sphingoid base N-palmitoyltransferase
This is an abbreviated version!
For detailed information about sphingoid base N-palmitoyltransferase, go to the full flat file.
Reaction
Synonyms
CerS4, CerS5, LASS5, longevity assurance homolog 5, mammalian ceramide synthase 5
ECTree
2.3.1.291 sphingoid base N-palmitoyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.3.1.291 - sphingoid base N-palmitoyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
myristoyl-CoA + a sphingoid base
N-(myristoyl)-sphingoid base + CoA
-
-
-
?
palmitoyl-CoA + a sphingoid base
an N-(palmitoyl)-sphingoid base + CoA
-
-
-
?
stearoyl-CoA + a sphingoid base
an N-(stearoyl)-sphingoid base + CoA
about 10% of the activity with palmitoyl-CoA
-
-
?
additional information
?
-
expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides
-
-
-
additional information
?
-
isoform LASS5 preferentially produces C14:0 and C16:0 ceramides
-
-
?
additional information
?
-
the enzyme is higly selective toward palmitoyl-CoA as acyl donor
-
-
?
