2.3.1.291: sphingoid base N-palmitoyltransferase

This is an abbreviated version!
For detailed information about sphingoid base N-palmitoyltransferase, go to the full flat file.

Reaction

Synonyms

CerS4, CerS5, LASS5, longevity assurance homolog 5, mammalian ceramide synthase 5

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.291 sphingoid base N-palmitoyltransferase

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Results	in table
16	AA Sequence
8	Application
5	Cloned(Commentary)
6	Expression
10	General Information
2	Inhibitors
2	Localization
2	Natural Substrates/ Products (Substrates)
23	Organism
2	Pathway
5	Posttranslational Modification
2	Protein Variants
1	Reaction
23	Reference
23	Source Tissue
10	Substrates and Products (Substrate)
14	Synonyms
1	Systematic Name

Engineering

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Engineering on EC 2.3.1.291 - sphingoid base N-palmitoyltransferase

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Go to Protein Variants Search

H220A/H221A

Homo sapiens

Q8N5B7

complete loss of activity

754101

additional information

Homo sapiens

Q8N5B7

a mutant based on the backbone of CerS5 (which generates C16-ceramide), containing an 11-residue sequence of a loop located between the last two putative transmembrane domainsfrom CerS2 (which generates C22-C24-ceramides), is altered such that it generates C22-C24 and other ceramides. The mutant generates C22:0-ceramide and C16:0-ceramide to a similar extent but also generates C18:0-, C20:0-, and C24:1-ceramides

757217