EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.2.1.127 | 1,6-alpha-L-fucosidase |
breast cancer cell |
- |
699825 |
2.3.1.B46 | 1-acylglycerophosphatidylinositol O-acyltransferase |
breast cancer cell |
- |
757632 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
breast cancer cell |
non-specific infiltrating duct and infiltrating lobular carcinomas |
721967 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
breast cancer cell |
- |
700197 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
breast cancer cell |
expression of the enzyme and the estrogen receptor is correlated |
668162 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
- |
685545, 711649, 713021, 726302, 740542, 740839, 740849, 761756, 761900 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
17beta-HSD1 is overexpressed in many breast tumors |
688272 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
the inhibition of the enzyme (17beta-HSD7) constitutes the basis of breast cancer cell proliferation |
761756 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
breast cancer cell |
- |
761900 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
- |
740017 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
breast cancer cell |
- |
675678 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
breast cancer cell |
- |
740017 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
- |
656788, 763397 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
3beta-hydroxysteroid dehydrogenase type 1 |
693887 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
isozyme 3beta-HSD1 |
662371 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
17beta-HSD7 is amplified in primary and progressive breast cancer |
763396 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
3beta-HSD1 is selectively expressed in human placenta, mammary glands and breast tumors in women |
763397 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
expression of 3beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth |
763404 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
selective expression of 3beta-HSD1 |
725813 |
2.4.1.152 | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase |
breast cancer cell |
- |
735901 |
3.6.1.62 | 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase |
breast cancer cell |
- |
758325 |
3.1.3.5 | 5'-nucleotidase |
breast cancer cell |
- |
682217, 691078, 693298, 750845 |
3.5.2.9 | 5-oxoprolinase (ATP-hydrolysing) |
breast cancer cell |
- |
694485 |
2.7.1.105 | 6-phosphofructo-2-kinase |
breast cancer cell |
- |
737973, 760902, 761915 |
7.6.2.2 | ABC-type xenobiotic transporter |
breast cancer cell |
- |
747044 |
6.4.1.2 | acetyl-CoA carboxylase |
breast cancer cell |
- |
672908, 675919 |
3.1.3.2 | acid phosphatase |
breast cancer cell |
- |
679089 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
breast cancer cell |
- |
764226 |
2.7.1.94 | acylglycerol kinase |
breast cancer cell |
enzyme overexpression |
739046 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
- |
670445, 719935, 754703, 754704, 755485 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
primary breast cancer cell BC1205 |
755485 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
primary breast cancer cell BC1302 |
755485 |
3.4.24.82 | ADAMTS-4 endopeptidase |
breast cancer cell |
- |
754958 |
3.5.4.4 | adenosine deaminase |
breast cancer cell |
- |
718704 |
3.5.4.4 | adenosine deaminase |
breast cancer cell |
the activity of isozyme ADA2 is increased |
668272 |
2.7.7.96 | ADP-D-ribose pyrophosphorylase |
breast cancer cell |
- |
761999, 762060 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
breast cancer cell |
- |
697114 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
breast cancer cell |
- |
696397, 703104, 728853 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
breast cancer cell |
overexpression of the enzyme is frequently observed in cancer tissues, such as breast cancer and glioblastoma |
728853 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
breast cancer cell |
- |
693867 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
breast cancer cell |
epithelial and metastatic |
758997 |
3.2.1.51 | alpha-L-fucosidase |
breast cancer cell |
- |
699825 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
breast cancer cell |
- |
681814, 727322 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
breast cancer cell |
- |
736910 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
breast cancer cell |
tissue samples of primary invasive breast cancer cases |
699089 |
1.13.11.33 | arachidonate 15-lipoxygenase |
breast cancer cell |
- |
676925 |
6.2.1.15 | arachidonate-CoA ligase |
breast cancer cell |
a breast cancer cell model, comprising different cell lines, expresses ACSL4 in all cell lines, high expression level |
716687 |
4.3.2.1 | argininosuccinate lyase |
breast cancer cell |
the enzynme is overexpressed in breast cancer |
748794 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
breast cancer cell |
different splicing variants |
748845 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
- |
735771, 735849, 756146 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
methylation status and the transcriptional activity of NAT1 in breast cancer tissues: methylation of NAT1 gene is identified in 39 of the breast carcinomas (54.2%), 23 normal (76.7%) and 25 benign breast tissue samples (80.6%). Breast cancer tissues show significantly lower methylation rates of the NAT1 promoters than the normal and benign tissues. Cancer tissues show lower methylation density rates than normal and benign breast tissues. Tissues that show aberrant methylation of NAT1 show significantly less mRNA expression compared with the unmethylated cases. 20 cancers from the methylated group show positive staining for the estrogen receptor (ER) (51.3%), while 72.7% from the unmethylated group stain positive |
689296 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
NAT1 is overexpressed in estrogen receptor-positive breast cancer |
686256 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
patients with ductal carcinoma |
676155 |
3.1.6.1 | arylsulfatase (type I) |
breast cancer cell |
enzyme expression is unaltered in cancer tissue compared to nonmalignant tissue |
707966 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
breast cancer cell |
- |
759882 |
3.5.1.12 | biotinidase |
breast cancer cell |
analysis of gene expression in breast cancer plasma, diverse tissue samples, profiling, overview |
711589 |
2.6.1.42 | branched-chain-amino-acid transaminase |
breast cancer cell |
- |
758728 |
2.6.1.42 | branched-chain-amino-acid transaminase |
breast cancer cell |
BCATc and BCATm are increased in breast cancer |
758657 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
breast cancer cell |
- |
664865 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
breast cancer cell |
differential expression of CaM-KI and CaM-KII in cell lines MCF-7 and MCF-10A |
664506 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast cancer cell |
- |
671357, 695621 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast cancer cell |
the enzyme expression is reduced in breast cancer cell specimen compared to healthy breast tissue |
672857 |
3.4.22.B29 | calpain 9 |
breast cancer cell |
expression analysis |
731549 |
3.4.22.52 | calpain-1 |
breast cancer cell |
- |
710164 |
3.4.22.53 | calpain-2 |
breast cancer cell |
- |
732050 |
3.4.22.26 | cancer procoagulant |
breast cancer cell |
- |
668137 |
2.3.1.21 | carnitine O-palmitoyltransferase |
breast cancer cell |
- |
757235 |
3.4.22.63 | caspase-10 |
breast cancer cell |
- |
710209 |
3.4.22.56 | caspase-3 |
breast cancer cell |
- |
695620, 696872, 697055 |
3.4.22.56 | caspase-3 |
breast cancer cell |
a breast cancer Dox resistant MCF-7/Dox cell line |
697054 |
3.4.22.59 | caspase-6 |
breast cancer cell |
- |
647467 |
3.4.22.59 | caspase-6 |
breast cancer cell |
invasive operable pT1 and pT2 ductal breast carcinoma are analysed of 210 patients: caspase-6 is overexpressed in 52.9% |
680072 |
3.4.22.61 | caspase-8 |
breast cancer cell |
- |
695620, 697053, 697261 |
3.4.22.62 | caspase-9 |
breast cancer cell |
- |
717277, 731452 |
2.1.1.6 | catechol O-methyltransferase |
breast cancer cell |
- |
658443, 702678 |
3.4.22.1 | cathepsin B |
breast cancer cell |
- |
36625, 753138 |
3.4.23.5 | cathepsin D |
breast cancer cell |
- |
695419, 695654, 711855, 755627 |
3.4.22.41 | cathepsin F |
breast cancer cell |
- |
668085 |
3.4.22.38 | cathepsin K |
breast cancer cell |
biopsy sites, benign lesions, ductal carcinoma in situ, and invasive breast tumors of different stages. Neither epithelial nor stromal expression of CTSK is significantly associated with recurrence-free or overall survival |
697375 |
3.4.22.15 | cathepsin L |
breast cancer cell |
- |
752936, 755110 |
3.4.18.1 | cathepsin X |
breast cancer cell |
- |
710431 |
3.5.1.23 | ceramidase |
breast cancer cell |
- |
733498 |
2.4.1.80 | ceramide glucosyltransferase |
breast cancer cell |
- |
722787, 736201 |
2.7.1.138 | ceramide kinase |
breast cancer cell |
- |
761664 |
2.7.1.138 | ceramide kinase |
breast cancer cell |
CERK expression is associated with an increased risk of recurrence in women with breast cancer |
737976 |
2.7.1.138 | ceramide kinase |
breast cancer cell |
tissue samples of primary invasive breast cancer cases |
699089 |
2.7.11.12 | cGMP-dependent protein kinase |
breast cancer cell |
- |
721503, 723796 |
3.6.4.B10 | chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing) |
breast cancer cell |
- |
756668 |
3.3.2.11 | cholesterol-5,6-oxide hydrolase |
breast cancer cell |
enzyme ChEH is upregulated |
752861 |
2.7.1.32 | choline kinase |
breast cancer cell |
- |
671362, 672898, 723311, 759595, 760183 |
3.4.21.45 | complement factor I |
breast cancer cell |
- |
753137 |
2.7.11.22 | cyclin-dependent kinase |
breast cancer cell |
- |
491470, 665497, 681873, 723656 |
3.4.11.3 | cystinyl aminopeptidase |
breast cancer cell |
N-methyl nitrosourea (NMU)-induced breast cancer |
753943 |
5.3.3.8 | DELTA3-DELTA2-enoyl-CoA isomerase |
breast cancer cell |
- |
691485 |
2.7.1.74 | deoxycytidine kinase |
breast cancer cell |
- |
761315 |
2.7.1.107 | diacylglycerol kinase (ATP) |
breast cancer cell |
- |
761306 |
2.3.1.57 | diamine N-acetyltransferase |
breast cancer cell |
- |
756851 |
2.3.1.57 | diamine N-acetyltransferase |
breast cancer cell |
in breast tumors, SSAT is increased contributing to an increase in acetylated polyamines |
701622 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
breast cancer cell |
- |
686604, 688302, 689367 |
5.6.2.1 | DNA topoisomerase |
breast cancer cell |
- |
750368 |