Literature summary for 2.3.1.21 extracted from

Menezes dos Reis, L.; Adamoski, D.; Ornitz Oliveira Souza, R.; Rodrigues Ascencao, C.F.; Sousa de Oliveira, K.R.; Correa-da-Silva, F.; Malta de Sa Patroni, F.; Meira Dias, M.; Consonni, S.R.; Mendes de Moraes-Vieira, P.M.; Silber, A.M.; Dias, S.M.G.
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells (2019), J. Biol. Chem., 294, 9342-9357 .

Application

Application	Comment	Organism
medicine	triple-negative breast cancer cells resistant to glutaminase inhibitor CB-839 have increased CPT2 protein and CPT1 activity levels. CB-839-resistant triple-negative breast cancer cells mobilize more fatty acids into mitochondria for oxidation	Homo sapiens
medicine	triple-negative breast cancer cells resistant to glutaminase inhibitor CB-839 have increased CPT2 protein and CPT1 activity levels. CB-839-resistant triple-negative breast cancer cells mobilize more fatty acids into mitochondria for oxidation. Inhibition of both glutaminase and CPT1 decreases cell proliferation and migration of CB-839-resistant cells compared with single inhibition of each enzyme	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Homo sapiens	P23786	-	-

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
BT-549 cell	-	Homo sapiens	-
HCC-1937 cell	-	Homo sapiens	-
HCC-70 cell	-	Homo sapiens	-
MDA-MB-157 cell	-	Homo sapiens	-
MDA-MB-453 cell	-	Homo sapiens	-
MDA-MB-468 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)