Application | Comment | Organism |
---|---|---|
medicine | isoform FUT4 is a regulator of epithelial-mesenchymal transition in breast cancer cells and a target for cancer therapy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22083 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
fucosyltransferase IV | - |
Homo sapiens |
FUT4 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | breast cancer cell lines display increased expression of isoform FUT4 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | fucosyltransferase IV is implicated in the modulation of cell migration, invasion and cancer metastasis. The enzyme has a role in epithelial-mesenchymal transition through activation of the phosphatidylinositol 3-kinase/Akt and nuclear factor-kappaB signaling systems, which induce the key mediators Snail and MMP-9 and facilitate the acquisition of a mesenchymal phenotype | Homo sapiens |