Literature summary for 1.1.1.270 extracted from

Wang, X.Q.; Aka, J.A.; Li, T.; Xu, D.; Doillon, C.J.; Lin, S.X.
Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78 (2017), J. Steroid Biochem. Mol. Biol., 172, 188-197 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P56937	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	17beta-HSD7 is amplified in primary and progressive breast cancer	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
17beta-HSD7	-	Homo sapiens
17beta-hydroxysteroid dehydrogenase type 7	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression is elevated in ER+ postmenopausal breast cancer and progressive breast cancer by TNM stage (local lymph node invasion and distant metastases)	up

General Information

General Information	Comment	Organism
metabolism	the anti-apoptotic protein GRP78 is a key regulatory protein related to 17beta-HSD7 inhibition and effect	Homo sapiens
metabolism	the enzyme (17beta-HSD7) promotes breast cancer cell growth via dual-catalytic activity by modulating estradiol and DHT	Homo sapiens

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Release 2023.1 (January 2023)