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CMP + trisialoganglioside GT1a
CMP-N-acetylneuraminate + disialoganglioside GD1a
-
-
-
-
?
CMP-alpha-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-alpha-N-acetylneuraminate + NeuAc-alpha2,8-NeuAc-alpha2,3-Gal-beta1,4-Glc-beta-FCHASE
GMP + ?
CMP-N-acetylneuraminate + (11-azidoundecyl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosid)onic acid
CMP + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid
CMP-N-acetylneuraminate + (methyl S-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onic acid
CMP + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galactonon-2-ulopyranosylonic acid
CMP-N-acetylneuraminate + 4-chlorophenyl 6-S-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-1,6-dithio-beta-D-galactopyranoside
CMP + 4-chlorophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-S-1,6-dithio-beta-D-galactopyranoside
CMP-N-acetylneuraminate + a ganglioside GD1a
a ganglioside GT1a + CMP + H+
-
-
-
-
?
CMP-N-acetylneuraminate + a ganglioside GD3
a ganglioside GT3 + CMP + H+
-
-
-
-
?
CMP-N-acetylneuraminate + a ganglioside GM3
a ganglioside GD3 + CMP + H+
CMP-N-acetylneuraminate + a ganglioside GT1b
a ganglioside GQ1b + CMP + H+
-
-
-
-
?
CMP-N-acetylneuraminate + adenosine A2A receptor
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + alpha-2,8-linked polysialic acid
?
-
-
-
-
?
CMP-N-acetylneuraminate + alpha-2,8-linked polysialic acid
CMP + ?
-
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
-
i.e. sialosylneolactotetraosylceramide or ganglioside LM1
i.e. disialosylneolactotetraosylceramide or ganglioside LD1c
?
CMP-N-acetylneuraminate + beta-sialic acid
CMP + alpha-N-acetylneuraminyl-(2->8)-beta-N-acetylneuraminate
CMP-N-acetylneuraminate + bovine submaxillary mucin
CMP + ?
substrate for isoform ST8Sia-VI, 100% activity
-
-
?
CMP-N-acetylneuraminate + disialoganglioside GD1a
CMP + trisialoganglioside GT1a
-
-
-
?
CMP-N-acetylneuraminate + dopamine D1 receptor
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + dopamine D2 receptor
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GD3
ganglioside GT3 + CMP + H+
NeuNAcalpha(2->8)NeuNAcalpha(2->3)Galbeta(1->4)Glc->Cer
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
CMP-N-acetylneuraminate + ganglioside GM3
ganglioside GD3 + CMP + H+
NeuNAcalpha(2->3)Galbeta(1->4)Glc->Cer
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3 amide
CMP + ganglioside GD3 amide
-
11% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3 methyl ester
CMP + ganglioside GD3 methyl ester
-
10% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3 methylamide
CMP + ganglioside GD3 methylamide
-
1% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + ganglioside LM1
CMP + ganglioside LD1c
-
-
-
-
?
CMP-N-acetylneuraminate + ganglioside lyso-GM3
CMP + ganglioside lyso-GD3
-
70% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + ganglioside N-acetyl-lyso-GM3
CMP + ganglioside N-acetyl-lyso-GD3
-
120% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + ganglioside N-octanoyl-lyso-GM3
CMP + ganglioside N-octanoyl-lyso-GD3
-
101% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM3
CMP + ganglioside N1-pyrenyl-dodecanoyl-lyso-GD3
-
93% of the activity compared to ganglioside GM3
-
-
?
CMP-N-acetylneuraminate + methyl S-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galactonon-2-ulopyranosylonic acid)-(2->6)-(6-thio-beta-D-galactopyranosyl)-(1->4)-O-beta-D-glucopyranoside
CMP + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galactonon-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-(6-thio-beta-D-galactopyranosyl)-(1->4)-beta-D-glucopyranoside
-
-
19% yield
-
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-N-acetylneuraminate + N-butyrylneuraminyl-alpha-2,3-galactosyl-beta-1,4-glucosyl-beta-1,1-ceramide
CMP + ?
-
sialylated at about 60% the rate of GM3
-
-
?
CMP-N-acetylneuraminate + N-glycolylneuraminyl-alpha-2,3-galactosyl-beta-1,4-glucosyl-beta-1,1-ceramide
CMP + ?
-
-
-
-
?
CMP-N-acetylneuraminate + N-lyso-GM3
CMP + N-lyso-GD3
-
N-acetyl derivative is a better substrate than GM3, detergent-like effect
-
?
CMP-N-acetylneuraminate + neural cell adhesion molecule
?
-
-
-
-
?
CMP-N-acetylneuraminate + neural cell adhesion molecule
CMP + ?
CMP-N-acetylneuraminate + neuropilin-1
CMP + ?
neuropilin-1 is polysialylated at about 50% of the level of neuropilin-2 but not polysialylated when it lacks its cytoplasmic tail and transmembrane region and is secreted from the cell
-
-
?
CMP-N-acetylneuraminate + neuropilin-2
CMP + ?
CMP-N-acetylneuraminate + trisialoganglioside GT1b
CMP + ganglioside GQ1b
-
-
-
?
CMP-N-acetylneuraminate + type V adenylyl cyclase
CMP + ?
-
-
-
?
CMP-Neu5Ac + GT3-FCHASE
CMP + long polySia chains + ?
-
the trisialylganglioside analogue GT3-FCHASE as artificial acceptor substrate
-
-
?
additional information
?
-
CMP-alpha-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
-
-
?
CMP-alpha-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
branch-point enzyme in ganglioside biosynthetic sequence
-
-
?
CMP-alpha-N-acetylneuraminate + NeuAc-alpha2,8-NeuAc-alpha2,3-Gal-beta1,4-Glc-beta-FCHASE
GMP + ?
-
-
-
-
?
CMP-alpha-N-acetylneuraminate + NeuAc-alpha2,8-NeuAc-alpha2,3-Gal-beta1,4-Glc-beta-FCHASE
GMP + ?
-
-
-
-
?
CMP-N-acetylneuraminate + (11-azidoundecyl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosid)onic acid
CMP + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid
-
-
12%, 7.7%, 5.3%, 4.5%, and 2.2% yield, respectively
-
?
CMP-N-acetylneuraminate + (11-azidoundecyl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosid)onic acid
CMP + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + 11-azidoundecyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid
-
-
12%, 7.7%, 5.3%, 4.5%, and 2.2% yield, respectively
-
?
CMP-N-acetylneuraminate + (methyl S-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onic acid
CMP + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galactonon-2-ulopyranosylonic acid
-
-
17% and 10.1% yield, respectively
-
?
CMP-N-acetylneuraminate + (methyl S-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onic acid
CMP + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid + methyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galactonon-2-ulopyranosylonic acid
-
-
17% and 10.1% yield, respectively
-
?
CMP-N-acetylneuraminate + 4-chlorophenyl 6-S-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-1,6-dithio-beta-D-galactopyranoside
CMP + 4-chlorophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-S-1,6-dithio-beta-D-galactopyranoside
-
-
-
-
?
CMP-N-acetylneuraminate + 4-chlorophenyl 6-S-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-1,6-dithio-beta-D-galactopyranoside
CMP + 4-chlorophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-S-1,6-dithio-beta-D-galactopyranoside
-
-
-
-
?
CMP-N-acetylneuraminate + a ganglioside GM3
a ganglioside GD3 + CMP + H+
-
-
-
-
?
CMP-N-acetylneuraminate + a ganglioside GM3
a ganglioside GD3 + CMP + H+
-
-
-
-
?
CMP-N-acetylneuraminate + a ganglioside GM3
a ganglioside GD3 + CMP + H+
-
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
-
-
?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
ganglioside GD3 is the minimal acceptor required for polysialylation
-
-
?
CMP-N-acetylneuraminate + beta-sialic acid
CMP + alpha-N-acetylneuraminyl-(2->8)-beta-N-acetylneuraminate
-
-
21.5% yield
-
?
CMP-N-acetylneuraminate + beta-sialic acid
CMP + alpha-N-acetylneuraminyl-(2->8)-beta-N-acetylneuraminate
-
-
21.5% yield
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ?
substrate for isoform ST8Sia-I, 100% activity
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
-
-
?
CMP-N-acetylneuraminate + ganglioside GM3
CMP + ganglioside GD3
-
ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramideganglioside
-
-
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
-
-
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
i.e. sialosyllactosylceramide or ganglioside GM3, specificity is determined by the substrate's negative charge and the acyl-residue in amide bond to the amino group of neuraminic acid
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
poor substrates are GM3 methyl ester, GM3 amide or GM3 methyl amide, no substrates are neuraminyllactosylceramide or N-biotinylneuraminyllactosylceramide
i.e. disialosyllactosylceramide or ganglioside GD3
?
CMP-N-acetylneuraminate + neural cell adhesion molecule
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + neural cell adhesion molecule
CMP + ?
-
-
-
-
?
CMP-N-acetylneuraminate + neuropilin-2
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + neuropilin-2
CMP + ?
neuropilin-2 is polysialylated when either membraneassociated or soluble. The meprin A5 antigen-mu tyrosine phosphatase domain and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysialylation
-
-
?
additional information
?
-
-
(4-chlorophenyl 5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosid)onic acid is no substrate
-
-
?
additional information
?
-
-
(4-chlorophenyl 5-acetamido-3,5-dideoxy-2-thio-D-glycero-alpha-D-galacto-non-2-ulopyranosid)onic acid is no substrate
-
-
?
additional information
?
-
-
the minimum number of sialic acid residues on the acceptor molecule for activity in vitro is two, with a large increase in activity if the acceptor carries three sialic residues. The polysialyltransferase from Neisseria meningitidis generates longer reaction products than the enzyme from Escherichia coli on synthetic FCHASE acceptors. Products are a heterogeneous mixture, including products with more than 50 Neu5Ac residues
-
-
?
additional information
?
-
-
overexpression of recombinant UDP-GlcNAc 2-epimerase/ManNAc 6-kinase in human embryonic kidney (HEK AD293) cells leads to an increase in mRNA levels for ST3Gal5 (GM3 synthase) and ST8Sia1 (GD3 synthase) as well as the biosynthetic products of these sialyltransferases, the GM3 and GD3 gangliosides. Down-regulation of UDP-GlcNAc 2-epimerase/ManNAc 6-kinase by RNA interference methods has the opposite, but consistent, effect of lowering ST3Gal5 and ST8Sia1 mRNAs and reducing GM3 and GD3 levels
-
-
?
additional information
?
-
-
the expression of hST8Sia III gene via the PI-3K signaling pathway is enhanced during KCl-induced differentiation of U-87 cells by increasing expression of beta-tubulin III
-
-
?
additional information
?
-
-
NF-kappaB plays an essential role in the transcriptional activity of GD3 synthase gene in Fas-induced Jurkat T cells. The translocation of NF-kB-binding protein to nucleus by Fas activation is also crucial for the increased expression of the GD3 synthase gene in Fas-activated Jurkat T cells
-
-
?
additional information
?
-
-
mouse enzyme is specific toward N-linked oligosaccharides of glycoproteins
-
-
?
additional information
?
-
isoform ST8Sia-I shows no activity with bovine submaxillary mucin
-
-
?
additional information
?
-
isoform ST8Sia-I shows no activity with bovine submaxillary mucin
-
-
?
additional information
?
-
-
isoform ST8Sia-I shows no activity with bovine submaxillary mucin
-
-
?
additional information
?
-
isoform ST8Sia-VI shows no activity towards ganglioside GM3
-
-
?
additional information
?
-
isoform ST8Sia-VI shows no activity towards ganglioside GM3
-
-
?
additional information
?
-
-
isoform ST8Sia-VI shows no activity towards ganglioside GM3
-
-
?
additional information
?
-
the glutamate receptors NR1, NR2A, NR2B, GluR1, and GluR2 are no substrates
-
-
-
additional information
?
-
-
the enzyme cannot use GM3 and GD3 gangliosides as substrates in B16 cells
-
-
-
additional information
?
-
-
the minimum number of sialic acid residues on the acceptor molecule for activity in vitro is two, with a large increase in activity if the acceptor carries three sialic residues. The polysialyltransferase from Neisseria meningitidis generates longer reaction products than the enzyme from Escherichia coli on synthetic FCHASE acceptors. Products are a heterogeneous mixture, including products with more than 50 Neu5Ac residues
-
-
?
additional information
?
-
-
enzyme is able to produce large polymers when it is part of the native capsule biosynthesis complex associated with the inner bacterial membrane
-
-
?
additional information
?
-
-
synthesizes long polysialic acid chains in a non-processive manner in vitro. PolyST activity towards short oligosialic acid acceptors (DP2 to DP5) is measured at constant CMP-Neu5Ac and enzyme concentrations
-
-
?
additional information
?
-
-
substrate specificity is strongly determined by the negative charge of the substrate and the acyl residue in amide bond to the amino group of neuraminic acid
-
-
?
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DELTA32I53S
-
truncated mutant. In addition to the alpha2,3- and alpha2,8-sialyltransferase activities of wild-type for the synthesis of GM3- and GD3-type oligosaccharides, respectively. The CstII DELTA32I53S mutant has alpha2,8-sialyltransferase, i. e. GT3 oligosaccharide synthase activity for the synthesis of GT3 oligosaccharide. It also has alpha2,8-sialidase i.e. GD3 oligosaccharide sialidase activity that catalyzes the specific cleavage of the alpha2,8-sialyl linkage of GD3-type oligosaccharides and alpha2,8-trans-sialidase, i. e. GD3 oligosaccharide trans-sialidase activity that catalyzes the transfer of a sialic acid from a GD3 oligosaccharide to a different GM3 oligosaccharide
H331K
catalytically inactive
N188D
mutation in a conserved residue identified by structure alignments between Campylobacter jejunii sialyltransferase CstII and human GD3-synthase, 6fold decrease in ratio Km to Vmax
R272A
mutation in a conserved residue identified by structure alignments between Campylobacter jejunii sialyltransferase CstII and human GD3-synthase, 4fold decrease in ratio Km to Vmax
S190A
mutation in a conserved residue identified by structure alignments between Campylobacter jejunii sialyltransferase CstII and human GD3-synthase, 4fold decrease in ratio Km to Vmax
A281V
the mutant of isoform ST8Sia-I shows 103.7% activity with ganglioside GM3
A328V
the mutant of isoform ST8Sia-VI shows 77.2% activity with bovine submaxillary mucin
C286A
the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3
C335A
the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin
E288N
the mutant of isoform ST8Sia-I shows 66.5% activity with ganglioside GM3
E333G
the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin
F277M
the mutant of isoform ST8Sia-I shows 81.1% activity with ganglioside GM3
G284E
the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3
I291L
the mutant of isoform ST8Sia-I shows 95.3% activity with ganglioside GM3
I327L
the mutant of isoform ST8Sia-VI shows 90% activity with bovine submaxillary mucin
K339S
the mutant of isoform ST8Sia-VI shows 34.6% activity with bovine submaxillary mucin
L278I
the mutant of isoform ST8Sia-I shows 11.9% activity with ganglioside GM3
L283V
the mutant of isoform ST8Sia-I shows 45.4% activity with ganglioside GM3
L340I
the mutant of isoform ST8Sia-VI shows 18.6% activity with bovine submaxillary mucin
M326F
the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin
N337E
the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin
S273A
the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3
S290K
the mutant of isoform ST8Sia-I shows 72.4% activity with ganglioside GM3
S322A
the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin
V279A
the mutant of isoform ST8Sia-I shows 85.6% activity with ganglioside GM3
V330A
the mutant of isoform ST8Sia-VI shows 92% activity with bovine submaxillary mucin
V332L
the mutant of isoform ST8Sia-VI shows 69.8% activity with bovine submaxillary mucin
W295A
the mutant of isoform ST8Sia-I shows 3.3% activity with ganglioside GM3
W344A
the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin
E153A
-
inactive, single-point mutation of NmB-polyST by QuickChange site-directed mutagenesis
G154A
-
inactive, single-point mutation of NmB-polyST by QuickChange site-directed mutagenesis
H278A
-
nearly inactive, single-point mutation of NmB-polyST by QuickChange site-directed mutagenesis. Vmax value for CMP-Neu5Ac is decreased by a factor 6 with respect to the wild-type enzyme and the Km value for CMP-Neu5Ac is 5fold
H278A/P279A
-
the H278A and P279A mutants maintain residual activity (below 10% of wild type), when both residues are changed to alanine simultaneously (H278A/P279A) enzyme activity is abolished
P279A
-
nearly inactive, single-point mutation of NmB-polyST by QuickChange site-directed mutagenesis. Vmax value for CMP-Neu5Ac is decreased by a factor of 4 with respect to the wild-type enzyme and the Km values for CMP-Neu5Ac is increased 3fold
additional information
morpholino knock-down of St8SiaIII leads to anomalous somite morphologies, including defects in segment boundary formation and myotendious-junction integrity
additional information
-
morpholino knock-down of St8SiaIII leads to anomalous somite morphologies, including defects in segment boundary formation and myotendious-junction integrity
additional information
-
construction of fusion proteins of polysialyltransferase enzyme with the bifunctional alpha-2,3/alpha-2,8-sialyltransferase from Campylobacter jejuni to create self priming polysialyltransferases. The bifunctional sialyltransferase utilizes various synthetic disaccharide acceptors with a terminal galactose
additional information
-
overexpression of GD3 synthase in Chang liver cells increases the expression of the microsomal triglyceride transfer protein gene, but GM3 synthase-transfected cells do not. The levels of GM3 and GD3 gangliosides in each of the transfected cells are increased in the cell extract as well as the medium. In addition, GD3 synthase-transfected cells show an increased secretion of triglyceride-enriched apoB. In contrast, the triglyceride content in GM3 synthase-transfected cells is relatively lower. Treatment with small interfering RNAs and GD3 antibody decreases apoB secretion
additional information
-
transfection of K-562 cells with GD3 synthase gene results in specific increase in membrane transglutaminase 2 protein and accelerate the erythroid differentiation. Treatment with GD3 synthase small interfering RNA results in decrease of membrane transglutaminase 2 protein
additional information
analysis of the role of enzyme GD3S in primary tumor formation and metastasis in syngeneic wild-type BALB/c mice, in which tumors are developed, and in 4T1 cells, inhibiting or supressing the enzyme by triptolide-treatment and expressing control shRNA or GD3S shRNA, respectively. FOXC2 is silenced in MDA-MB-231 and HMLE-Snail cells. Phenotypes, overview
additional information
-
analysis of the role of enzyme GD3S in primary tumor formation and metastasis in syngeneic wild-type BALB/c mice, in which tumors are developed, and in 4T1 cells, inhibiting or supressing the enzyme by triptolide-treatment and expressing control shRNA or GD3S shRNA, respectively. FOXC2 is silenced in MDA-MB-231 and HMLE-Snail cells. Phenotypes, overview
additional information
-
examination of amyloid beta-ganglioside interactions in neural tissue from mice lacking the gene coding for GD3 synthase, St8sia1, and in a double-transgenic mouse model of Alzheimers disease mutated in amyloid precursor protein APP and presenilin PSEN1 cross-bred with GD3 synthase deficient mice. In primary neurons and astrocytes lacking GD3S, amyloid beta-induced cell death and amyloid beta aggregation are inhibited. Like GD3 synthase eficient and APP/PSEN1 double-transgenic mice, APP/PSEN1/GD3 synthase deficient triple-mutant mice are indistinguishable from wild-type mice on casual examination. APP/PSEN1 double-transgenics exhibit robust impairments on a number of reference-memory tasks. In contrast, APP/PSEN1/GD3 synthase deficient triple-mutant mice perform as well as wild-type control and GD3-synthase deficient mice. Consistent with the behavioral improvements, both aggregated and unaggregated amyloid beta and associated neuropathology are almost completely eliminated in triple-mutant mice
additional information
-
study on electrophysiological parameters of synaptic transmission at the neuromuscular junction ex vivo of a GD3 synthase knockout mouse, expressing only the O- and a-series gangliosides, as well as of a GM2/GD2-synthase*GD3-synthase double-knockout mouse, lacking all gangliosides except GM3. No major synaptic deficits are found in either null-mutant. Some extra degree of rundown of acetylcholine release at high intensity use is present at the dKO NMJ and a temperature-specific increase in acetylcholine release at 35°C is observed in GD3-synthase knockout neuromuscular junctions, compared with wild-type
additional information
comparisons of relative expressions of ganglioside metabolism genes in wild-type and IDUA knockout mice, overview
additional information
-
comparisons of relative expressions of ganglioside metabolism genes in wild-type and IDUA knockout mice, overview
-
additional information
-
construction of fusion proteins of polysialyltransferase enzyme with the bifunctional alpha-2,3/alpha-2,8-sialyltransferase from Campylobacter jejuni to create self priming polysialyltransferases. The bifunctional sialyltransferase utilizes various synthetic disaccharide acceptors with a terminal galactose and can be used to create polysialic acid on O-linked glycopeptides
additional information
-
mutational analysis of NmBpolyST, emphasized by structural data available for the Pasteurella multocida sialyltransferase PmST1, functional importance of the two functional motifs for enzyme catalysis and CMP-Neu5Ac binding shown
additional information
-
removal of 23 (DELTA23NmBpolyST) and 33 (DELTA33NmB-polyST) amino acids from the N-terminus has only slight effects on solubility and activity of NmB-polyST. Deletion of the first 64 amino acids (DELTA64NmB-polyST) shifts the majority of the expressed protein to the insoluble fraction and no enzymatic activity is detected in soluble or insoluble fractions. Truncated NmBpolySTs lacking the C-terminal domain either partially (NmB-polySTDELTA22, NmB-polySTDELTA60) or completely (NmB-polySTDELTA94, NmB-polySTDELTA95, NmB-polySTDELTA97): each C-terminal truncation completely abolished enzymatic activity
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Daniotti, J.L.; Martina, J.A.; Giraudo, C.G.; Zurita, A.R.; Maccioni, H.J.F.
GM3 alpha2,8-sialyltransferase (GD3 synthase): protein characterization and sub-Golgi location in CHO-K1 cells
J. Neurochem.
74
1711-1720
2000
Gallus gallus
brenda
Klein, D.; Pohlentz, G.; Schwarzmann, G.; Sandhoff, K.
Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver
Eur. J. Biochem.
167
417-424
1987
Rattus norvegicus
brenda
Yusuf, H.K.M.; Schwarzmann, G.; Pohlentz, G.; Sandhoff, K.
Oligosialogangliosides inhibit GM2- and GD3-synthesis in isolated Golgi vesicles from rat liver
Biol. Chem. Hoppe-Seyler
368
455-462
1987
Rattus norvegicus
brenda
Higashi, H.; Basu, M.; Basu, S.
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain
J. Biol. Chem.
260
824-828
1985
Gallus gallus
brenda
Freischutz, B.; Saito, M.; Rahmann, H.; Yu, R.K.
Activities of five different sialyltransferases in fish and rat brains
J. Neurochem.
62
1965-1973
1994
Oreochromis mossambicus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Busam, K.; Decker, K.
Ganglioside biosynthesis in rat liver. Characterization of three sialyltransferases
Eur. J. Biochem.
160
23-30
1986
Rattus norvegicus
brenda
Iber, H.; van Echten, G.; Sandhoff, K.
Substrate specificity of alpha 2->3-sialyltransferases in ganglioside biosynthesis of rat liver Golgi
Eur. J. Biochem.
195
115-120
1991
Rattus norvegicus
brenda
Fishman, P.H.; Bradley, R.M.; Henneberry, R.C.
Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase
Arch. Biochem. Biophys.
172
618-626
1976
Homo sapiens
brenda
Trinchera, M.; Pirovano, B.; Ghidoni, R.
Sub-Golgi distribution in rat liver of CMP-NeuAc GM3- and CMP-NeuAc:GT1b alpha 2->8sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis
J. Biol. Chem.
265
18242-18247
1990
Rattus norvegicus
brenda
Gu, X.B.; Gu, T.J.; Yu, R.K.
Purification to homogeneity of GD3 synthase and partial purification of GM3 synthase from rat brain
Biochem. Biophys. Res. Commun.
166
387-393
1990
Rattus norvegicus
brenda
Eppler, C.M.; Morr, D.J.; Keenan, T.W.
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides
Biochim. Biophys. Acta
619
332-343
1980
Rattus norvegicus
brenda
Eppler, C.M.; Morr, D.J.; Keenan, T.W.
Ganglioside biosynthesis in rat liver: characterization of cytidine-5-monophospho-n-acetylneuraminic acid:hematoside (GM3) sialyltransferase
Biochim. Biophys. Acta
619
318-331
1980
Rattus norvegicus
brenda
Yohe, H.C.; Yu, R.K.
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a
J. Biol. Chem.
255
608-613
1980
Gallus gallus
brenda
Sasaki, K.; Kurata, K.; Kojima, N.; Kurosawa, N.; Ohta, S.; Hanai, N.; Tsuji, S.; Nishi, T.
Expression cloning of a GM3-specific alpha 2,8-sialyltransferase (GD3 synthase)
J. Biol. Chem.
269
15950-15956
1994
Homo sapiens (Q92185), Homo sapiens
brenda
Kojima, N.; Yoshida, Y.; Kurosawa, N.; Lee, Y.C.; Tsuji, S.
Enzymatic activity of a developmentally regulated member of the sialyltransferase family (STX): evidence for alpha 2,8-sialyltransferase activity toward N-linked oligosaccharides
FEBS Lett.
360
1-4
1995
Mus musculus
brenda
Watanabe, Y.; Nara, K.; Takahashi, H.; Nagai, Y.; Sanai, Y.
The molecular cloning and expression of alpha 2,8-sialyltransferase (GD3 synthase) in a rat brain
J. Biochem.
120
1020-1027
1996
Rattus norvegicus
brenda
Bieberich, E.; Tencomnao, T.; Kapitonov, D.; Yu, R.K.
Effect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells
J. Neurochem.
74
2359-2364
2000
Mus musculus, Rattus norvegicus
brenda
Ardail, D.; Popa, I.; Bodennec, J.; Louisot, P.; Schmitt, D.; Portoukalian, J.
The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases
Biochem. J.
371
1013-1019
2003
Rattus norvegicus
brenda
Tomassini, B.; Malisan, F.; Franchi, L.; Nicolo, C.; Calvo, G.B.; Saito, T.; Testi, R.
Calnexin suppresses GD3 synthase-induced apoptosis
FASEB J.
18
1553-1555
2004
Homo sapiens
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Ha, K.T.; Lee, Y.C.; Kim, C.H.
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Homo sapiens
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Homo sapiens
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