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Literature summary for 2.4.3.8 extracted from

  • Takashima, S.; Matsumoto, T.; Tsujimoto, M.; Tsuji, S.
    Effects of amino acid substitutions in the sialylmotifs on molecular expression and enzymatic activities of alpha2,8-sialyltransferases ST8Sia-I and ST8Sia-VI (2013), Glycobiology, 23, 603-612.
    View publication on PubMed
Search for more literature for 2.4.3.8

Protein Variants

Protein Variants Comment Organism
A281V the mutant of isoform ST8Sia-I shows 103.7% activity with ganglioside GM3 Mus musculus
A328V the mutant of isoform ST8Sia-VI shows 77.2% activity with bovine submaxillary mucin Mus musculus
C286A the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3 Mus musculus
C335A the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
E288N the mutant of isoform ST8Sia-I shows 66.5% activity with ganglioside GM3 Mus musculus
E333G the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
F277M the mutant of isoform ST8Sia-I shows 81.1% activity with ganglioside GM3 Mus musculus
G284E the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3 Mus musculus
I291L the mutant of isoform ST8Sia-I shows 95.3% activity with ganglioside GM3 Mus musculus
I327L the mutant of isoform ST8Sia-VI shows 90% activity with bovine submaxillary mucin Mus musculus
K339S the mutant of isoform ST8Sia-VI shows 34.6% activity with bovine submaxillary mucin Mus musculus
L278I the mutant of isoform ST8Sia-I shows 11.9% activity with ganglioside GM3 Mus musculus
L283V the mutant of isoform ST8Sia-I shows 45.4% activity with ganglioside GM3 Mus musculus
L340I the mutant of isoform ST8Sia-VI shows 18.6% activity with bovine submaxillary mucin Mus musculus
M326F the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
N337E the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
S273A the mutant of isoform ST8Sia-I shows no activity with ganglioside GM3 Mus musculus
S290K the mutant of isoform ST8Sia-I shows 72.4% activity with ganglioside GM3 Mus musculus
S322A the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus
V279A the mutant of isoform ST8Sia-I shows 85.6% activity with ganglioside GM3 Mus musculus
V330A the mutant of isoform ST8Sia-VI shows 92% activity with bovine submaxillary mucin Mus musculus
V332L the mutant of isoform ST8Sia-VI shows 69.8% activity with bovine submaxillary mucin Mus musculus
W295A the mutant of isoform ST8Sia-I shows 3.3% activity with ganglioside GM3 Mus musculus
W344A the mutant of isoform ST8Sia-VI shows no activity with bovine submaxillary mucin Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q64687
-
-
Mus musculus Q8K4T1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
COS-7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + bovine submaxillary mucin substrate for isoform ST8Sia-VI, 100% activity Mus musculus CMP + ?
-
 ?
CMP-N-acetylneuraminate + ganglioside GM3 substrate for isoform ST8Sia-I, 100% activity Mus musculus CMP + ?
-
 ?
additional information isoform ST8Sia-I shows no activity with bovine submaxillary mucin Mus musculus ?
-
 ?
additional information isoform ST8Sia-VI shows no activity towards ganglioside GM3 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha2,8-sialyltransferase
-
 Mus musculus
ST8Sia-I isoform Mus musculus
ST8Sia-VI isoform Mus musculus

General Information

General Information Comment Organism
metabolism isoform ST8Sia-I is involved in the synthesis of ganglioside GD3 Mus musculus
metabolism isoform ST8Sia-VI isinvolved in the synthesis of disialic acid structures on O-glycans Mus musculus