Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus | |
Calmodulin | dependent on | Homo sapiens | |
Calmodulin | dependent on | Rattus norvegicus | |
additional information | redox regulation of CaM-kinases, overview, CaM-KII and CaM-KIV activation mechanisms, overview | Mus musculus | |
additional information | redox regulation of CaM-kinases, overview, CaM-KII and CaM-KIV activation mechanisms, overview | Homo sapiens | |
additional information | redox regulation of CaM-kinases, overview, CaM-KII and CaM-KIV activation mechanisms, overview | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | CaM-kinases act as potential targets in cancer therapy, strategies, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Calmidazolium | calmodulin antagonist | Homo sapiens | |
Calmidazolium | calmodulin antagonist | Mus musculus | |
Calmidazolium | calmodulin antagonist | Rattus norvegicus | |
K252a | inhibits CaM-KII | Homo sapiens | |
K252a | inhibits CaM-KII | Mus musculus | |
K252a | inhibits CaM-KII | Rattus norvegicus | |
KN-62 | - |
Homo sapiens | |
KN-62 | - |
Mus musculus | |
KN-62 | - |
Rattus norvegicus | |
KN-93 | - |
Homo sapiens | |
KN-93 | - |
Mus musculus | |
KN-93 | - |
Rattus norvegicus | |
additional information | no inhibition by KN-92, redox regulation of CaM-kinases, inhibition mechanisms, overview | Homo sapiens | |
additional information | no inhibition by KN-92, redox regulation of CaM-kinases, inhibition mechanisms, overview | Mus musculus | |
additional information | no inhibition by KN-92, redox regulation of CaM-kinases, inhibition mechanisms, overview | Rattus norvegicus | |
trifluoperazine dimaleate | calmodulin antagonist | Homo sapiens | |
trifluoperazine dimaleate | calmodulin antagonist | Mus musculus | |
trifluoperazine dimaleate | calmodulin antagonist | Rattus norvegicus | |
W-13 | calmodulin antagonist | Homo sapiens | |
W-13 | calmodulin antagonist | Mus musculus | |
W-13 | calmodulin antagonist | Rattus norvegicus | |
W-7 | calmodulin antagonist | Homo sapiens | |
W-7 | calmodulin antagonist | Mus musculus | |
W-7 | calmodulin antagonist | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | CaM-KIV | Mus musculus | 5829 | - |
cytosol | CaM-KIV | Homo sapiens | 5829 | - |
cytosol | CaM-KIV | Rattus norvegicus | 5829 | - |
nucleus | CaM-KIV predominantly | Mus musculus | 5634 | - |
nucleus | CaM-KIV predominantly | Homo sapiens | 5634 | - |
nucleus | CaM-KIV predominantly | Rattus norvegicus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Homo sapiens | |
Ca2+ | dependent on | Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + I-kappaB | Mus musculus | substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | Homo sapiens | substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | Rattus norvegicus | substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB | ADP + phosphorylated I-kappaB | - |
? | |
additional information | Mus musculus | CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview | ? | - |
? | |
additional information | Homo sapiens | CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview | ? | - |
? | |
additional information | Rattus norvegicus | CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
CaM-KII is encoded by four different genes encoding isozymes alpha-delta, alternative splicing results in 24 different enzyme variants | - |
Mus musculus | - |
CaM-KII is encoded by four different genes encoding isozymes alpha-delta, alternative splicing results in 24 different enzyme variants | - |
Rattus norvegicus | - |
CaM-KII is encoded by four different genes encoding isozymes alpha-delta, alternative splicing results in 24 different enzyme variants | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CaM-KIV is phosphorylated and activated by the CaM-K kinase at Thr200, CaM-KI is also phosphorylated by CaM-KK, CaM-kinases II and IV become reversibly autophosphorylated after Ca2+/calmodulin-dependent activation, which renders the enzyme activity autonomous, CaM-KII is phosphorylated in the pseudosubstrate domain | Mus musculus |
phosphoprotein | CaM-KIV is phosphorylated and activated by the CaM-K kinase at Thr200, CaM-KI is also phosphorylated by CaM-KK, CaM-kinases II and IV become reversibly autophosphorylated after Ca2+/calmodulin-dependent activation, which renders the enzyme activity autonomous, CaM-KII is phosphorylated in the pseudosubstrate domain | Homo sapiens |
phosphoprotein | CaM-KIV is phosphorylated and activated by the CaM-K kinase at Thr200, CaM-KI is also phosphorylated by CaM-KK, CaM-kinases II and IV become reversibly autophosphorylated after Ca2+/calmodulin-dependent activation, which renders the enzyme activity autonomous, CaM-KII is phosphorylated in the pseudosubstrate domain | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
breast cancer cell | - |
Homo sapiens | - |
fibroblast | CaM-KI | Mus musculus | - |
fibroblast | CaM-KI | Homo sapiens | - |
fibroblast | CaM-KI | Rattus norvegicus | - |
HeLa cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
liver | CaM-KIV | Mus musculus | - |
liver | CaM-KIV | Homo sapiens | - |
liver | CaM-KIV | Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | - |
Homo sapiens | - |
neuron | - |
Rattus norvegicus | - |
prostate cancer cell | - |
Homo sapiens | - |
T-lymphocyte | high expression of CaM-KIV | Mus musculus | - |
T-lymphocyte | high expression of CaM-KIV | Homo sapiens | - |
T-lymphocyte | high expression of CaM-KIV | Rattus norvegicus | - |
testis | high expression of CaM-KIV | Mus musculus | - |
testis | high expression of CaM-KIV | Homo sapiens | - |
testis | high expression of CaM-KIV | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt | substrate of CaM-KII, phosphorylation at Thr308 | Mus musculus | ADP + phosphorylated Akt | - |
? | |
ATP + Akt | substrate of CaM-KII, phosphorylation at Thr308 | Homo sapiens | ADP + phosphorylated Akt | - |
? | |
ATP + Akt | substrate of CaM-KII, phosphorylation at Thr308 | Rattus norvegicus | ADP + phosphorylated Akt | - |
? | |
ATP + CREB | i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133 | Mus musculus | ADP + phosphorylated CREB | - |
? | |
ATP + CREB | i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133 | Homo sapiens | ADP + phosphorylated CREB | - |
? | |
ATP + CREB | i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133 | Rattus norvegicus | ADP + phosphorylated CREB | - |
? | |
ATP + I-kappaB | substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB | Mus musculus | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB | Homo sapiens | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB | Rattus norvegicus | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | substrate of CaM-KII | Mus musculus | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | substrate of CaM-KII | Homo sapiens | ADP + phosphorylated I-kappaB | - |
? | |
ATP + I-kappaB | substrate of CaM-KII | Rattus norvegicus | ADP + phosphorylated I-kappaB | - |
? | |
ATP + synapsin I | substrate of CaM-KI | Mus musculus | ADP + phosphorylated synapsin I | - |
? | |
ATP + synapsin I | substrate of CaM-KI | Homo sapiens | ADP + phosphorylated synapsin I | - |
? | |
ATP + synapsin I | substrate of CaM-KI | Rattus norvegicus | ADP + phosphorylated synapsin I | - |
? | |
ATP + synapsin II | substrate of CaM-KI | Mus musculus | ADP + phosphorylated synapsin II | - |
? | |
ATP + synapsin II | substrate of CaM-KI | Homo sapiens | ADP + phosphorylated synapsin II | - |
? | |
ATP + synapsin II | substrate of CaM-KI | Rattus norvegicus | ADP + phosphorylated synapsin II | - |
? | |
additional information | CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview | Mus musculus | ? | - |
? | |
additional information | CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview | Homo sapiens | ? | - |
? | |
additional information | CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
multimer | CaM-KII is a multimer of 10-12 catalytic subunits due to self-association | Mus musculus |
multimer | CaM-KII is a multimer of 10-12 catalytic subunits due to self-association | Homo sapiens |
multimer | CaM-KII is a multimer of 10-12 catalytic subunits due to self-association | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase | - |
Mus musculus |
calcium/calmodulin-dependent protein kinase | - |
Homo sapiens |
calcium/calmodulin-dependent protein kinase | - |
Rattus norvegicus |
CaM-K I | - |
Mus musculus |
CaM-K I | - |
Homo sapiens |
CaM-K I | - |
Rattus norvegicus |
CaM-K II | - |
Mus musculus |
CaM-K II | - |
Homo sapiens |
CaM-K II | - |
Rattus norvegicus |
CaM-K IV | - |
Mus musculus |
CaM-K IV | - |
Homo sapiens |
CaM-K IV | - |
Rattus norvegicus |
CaM-kinase I | - |
Mus musculus |
CaM-kinase I | - |
Homo sapiens |
CaM-kinase I | - |
Rattus norvegicus |
CaM-kinase II | - |
Mus musculus |
CaM-kinase II | - |
Homo sapiens |
CaM-kinase II | - |
Rattus norvegicus |
CaM-kinase III | - |
Mus musculus |
CaM-kinase III | - |
Homo sapiens |
CaM-kinase III | - |
Rattus norvegicus |
CaM-kinase IV | - |
Mus musculus |
CaM-kinase IV | - |
Homo sapiens |
CaM-kinase IV | - |
Rattus norvegicus |
More | the enzyme belongs to the family of CaM-kinases, overview | Mus musculus |
More | the enzyme belongs to the family of CaM-kinases, overview | Homo sapiens |
More | the enzyme belongs to the family of CaM-kinases, overview | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |