Cloned (Comment) | Organism |
---|---|
gene agk, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acylglycerol | Homo sapiens | - |
ADP + acyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q53H12 | gene agk | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | enzyme overexpression | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
SKBR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acylglycerol | - |
Homo sapiens | ADP + acyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme overexpression significantly enhances, whereas silencing endogenous enzyme AGK inhibits the proliferation and tumorigenicity of breast cancer cells both in vitro and in vivo. Overexpression of AGK enhances G1-S phase transition in breast cancer cells, which is associated with activation of AKT, suppression of FOXO1 transactivity, downregulation of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 and upregulation of the cell cycle regulator cyclin D1 | Homo sapiens |
physiological function | acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor, FOXO1 is considered to be a tumor suppressor. The enzyme significantly correlates with patients' clinicopathologic characteristics, including clinical stage and tumor-nodule-metastasis (TNM) classification | Homo sapiens |