Application | Comment | Organism |
---|---|---|
medicine | amantadine can be used to determine enzyme cellular activity by measuring excretion of N1-acetylamantadine which may indicate the presence of cancer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amantadine | Homo sapiens | - |
CoA + N1-acetylamantadine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
bronchial epithelial cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
mammary epithelial cell | - |
Homo sapiens | - |
additional information | the enzyme is not detected in noncancerous human cells | Homo sapiens | - |
prostate adenocarcinoma cell | - |
Homo sapiens | - |
prostate epithelium cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amantadine | - |
Homo sapiens | CoA + N1-acetylamantadine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase-1 | - |
Homo sapiens |
SSAT-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | high levels of enzyme expression are measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. Increases in enzyme protein contents and gene expression in primary tumors is linked to a concomitant higher level of N1-acetylamantadine in urine of cancer patients upon ingestion of amantadine | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays a critical role in cell growth | Homo sapiens |