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Adenocarcinoma
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Albuminuria
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease.
Alzheimer Disease
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Breast Neoplasms
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.
Carcinogenesis
Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis.
Carcinogenesis
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
Carcinogenesis
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.
Carcinogenesis
Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/?-catenin signaling while up-regulating ligand dependent transcription factor PPAR?
Colorectal Neoplasms
Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: Exploring NHE-1, intracellular calcium homeostasis and Calpain 9.
Diabetes Mellitus, Type 2
The calpain family and human disease.
Kidney Diseases
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease.
Lymphatic Metastasis
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.
Neoplasm Metastasis
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.
Neoplasms
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.
Stomach Neoplasms
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.
Stomach Neoplasms
Isolation of two novel genes, down-regulated in gastric cancer.
Stomach Neoplasms
The calpain family and human disease.
Stomach Neoplasms
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
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365-370
2003
Homo sapiens (O14815), Rattus norvegicus (O35920), Mus musculus (Q9D805), Mus musculus C57/BL6J (Q9D805)
brenda
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (Q9D805), Mus musculus C57/BL6J (Q9D805)
brenda
Lee, H.J.; Sorimachi, H.; Jeong, S.Y.; Ishiura, S.; Suzuki, K.
Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract
Biol. Chem.
379
175-183
1998
Homo sapiens (O14815), Homo sapiens, Rattus norvegicus (O35920), Mus musculus (Q9D805), Mus musculus
brenda
Yoshikawa, Y.; Mukai, H.; Hino, F.; Asada, K.; Kato, I.
Isolation of two novel genes, down-regulated in gastric cancer
Jpn. J. Cancer Res.
91
459-463
2000
Homo sapiens (O14815), Homo sapiens
brenda
Markmann, A.; Schaefer, S.; Linz, W.; Loehn, M.; Busch, A.E.; Wohlfart, P.
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease
Cell. Physiol. Biochem.
15
109-116
2005
Rattus norvegicus (O35920)
brenda
Salem, M.; Rexroad, C.E.; Yao, J.
Identification of a novel gill-specific calpain from rainbow trout (Oncorhynchus mykiss)
Fish Physiol. Biochem.
32
1-6
2006
Oncorhynchus mykiss (Q596C5)
brenda
Davis, T.L.; Walker, J.R.; Finerty, P.J.; Mackenzie, F.; Newman, E.M.; Dhe-Paganon, S.
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition
J. Mol. Biol.
366
216-229
2007
Homo sapiens
brenda
Chen, C.J.; Nguyen, T.; Shively, J.E.
Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells
Exp. Cell Res.
316
638-648
2010
Homo sapiens
brenda
Davis, J.; Martin, S.G.; Patel, P.M.; Green, A.R.; Rakha, E.A.; Ellis, I.O.; Storr, S.J.
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer
BMC Cancer
14
995
2014
Homo sapiens (O14815)
brenda
Cui, H.X.; Wang, S.L.; Guo, L.P.; Liu, L.; Liu, R.R.; Li, Q.H.; Zheng, M.Q.; Zhao, G.P.; Wen, J.
Expression and effect of Calpain9 gene genetic polymorphism on slaughter indicators and intramuscular fat content in chickens
Poult. Sci.
97
3414-3420
2018
Gallus gallus
brenda
Kim, D.H.; Beckett, J.D.; Nagpal, V.; Seman-Senderos, M.A.; Gould, R.A.; Creamer, T.J.; MacFarlane, E.G.; Chen, Y.; Bedja, D.; Butcher, J.T.; Mitzner, W.; Rouf, R.; Hata, S.; Warren, D.S.; Dietz, H.C.
Calpain 9 as a therapeutic target in TGFbeta-induced mesenchymal transition and fibrosis
Sci. Transl. Med.
11
eaau2814
2019
Mus musculus
brenda