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EC 2.3.1.261 Details

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EC number

2.3.1.261

Accepted name

(4-hydroxyphenyl)alkanoate synthase

Reaction

(1) 4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 16 H⁺ = 17-(4-hydroxyphenyl)heptadecanoyl-[(4-hydroxyphenyl)alkanoate synthase] + 8 CO₂ + 8 CoA + 16 NADP⁺ + 8 H₂O;;(2) 4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 18 H⁺ + holo-[(4-hydroxyphenyl)alkanoate synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(4-hydroxyphenyl)alkanoate synthase] + 9 CO₂ + 9 CoA + 18 NADP⁺ + 9 H₂O

Other name(s)

msl7 (gene name), Pks15/1

Systematic name

malonyl-CoA:4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] malonyltransferase [(4-hydroxyphenyl)alkanoate-forming]

Comment

The enzyme is part of the biosynthetic pathway of phenolphthiocerol, a lipid that serves as a virulence factor of pathogenic mycobacteria. It catalyses the elongation of 4-hydroxybenzoate that is loaded on its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate intermediates. The enzyme adds either 8 or 9 malonyl-CoA units, resulting in formation of 17-(4-hydroxyphenyl)heptadecanoate or 19-(4-hydroxyphenyl)nonadecanoate, respectively. As the enzyme lacks a thioesterase domain [1], the product remains loaded on the acyl-carrier domain at the end of catalysis, and has to be hydrolysed by an as-yet unknown mechanism.

History

created 2017

EC Tree

1 Oxidoreductases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.1 amino-acid N-acetyltransferase

2.3.1.2 imidazole N-acetyltransferase

2.3.1.3 glucosamine N-acetyltransferase

2.3.1.4 glucosamine-phosphate N-acetyltransferase

2.3.1.5 arylamine N-acetyltransferase

2.3.1.6 choline O-acetyltransferase

2.3.1.7 carnitine O-acetyltransferase

2.3.1.8 phosphate acetyltransferase

2.3.1.9 acetyl-CoA C-acetyltransferase

2.3.1.10 hydrogen-sulfide S-acetyltransferase

2.3.1.11 thioethanolamine S-acetyltransferase

2.3.1.12 dihydrolipoyllysine-residue acetyltransferase

2.3.1.13 glycine N-acyltransferase

2.3.1.14 glutamine N-phenylacetyltransferase

2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase

2.3.1.16 acetyl-CoA C-acyltransferase

2.3.1.17 aspartate N-acetyltransferase

2.3.1.18 galactoside O-acetyltransferase

2.3.1.19 phosphate butyryltransferase

2.3.1.20 diacylglycerol O-acyltransferase

2.3.1.21 carnitine O-palmitoyltransferase

2.3.1.22 2-acylglycerol O-acyltransferase

2.3.1.23 1-acylglycerophosphocholine O-acyltransferase

2.3.1.24 sphingosine N-acyltransferase

2.3.1.25 plasmalogen synthase

2.3.1.26 sterol O-acyltransferase

2.3.1.27 cortisol O-acetyltransferase

2.3.1.28 chloramphenicol O-acetyltransferase

2.3.1.29 glycine C-acetyltransferase

2.3.1.30 serine O-acetyltransferase

2.3.1.31 homoserine O-acetyltransferase

2.3.1.32 lysine N-acetyltransferase

2.3.1.33 histidine N-acetyltransferase

2.3.1.34 D-tryptophan N-acetyltransferase

2.3.1.35 glutamate N-acetyltransferase

2.3.1.36 D-amino-acid N-acetyltransferase

2.3.1.37 5-aminolevulinate synthase

2.3.1.38 [acyl-carrier-protein] S-acetyltransferase

2.3.1.39 [acyl-carrier-protein] S-malonyltransferase

2.3.1.40 acyl-[acyl-carrier-protein]—phospholipid O-acyltransferase

2.3.1.41 β-ketoacyl-[acyl-carrier-protein] synthase I

2.3.1.42 glycerone-phosphate O-acyltransferase

2.3.1.43 phosphatidylcholine—sterol O-acyltransferase

2.3.1.44 N-acetylneuraminate 4-O-acetyltransferase

2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

2.3.1.46 homoserine O-succinyltransferase

2.3.1.47 8-amino-7-oxononanoate synthase

2.3.1.48 histone acetyltransferase

2.3.1.49 deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase

2.3.1.50 serine C-palmitoyltransferase

2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase

2.3.1.52 2-acylglycerol-3-phosphate O-acyltransferase

2.3.1.53 phenylalanine N-acetyltransferase

2.3.1.54 formate C-acetyltransferase

2.3.1.55 created 1976, deleted 1999

2.3.1.56 aromatic-hydroxylamine O-acetyltransferase

2.3.1.57 diamine N-acetyltransferase

2.3.1.58 2,3-diaminopropionate N-oxalyltransferase

2.3.1.59 gentamicin 2′-N-acetyltransferase

2.3.1.60 gentamicin 3-N-acetyltransferase

2.3.1.61 dihydrolipoyllysine-residue succinyltransferase

2.3.1.62 2-acylglycerophosphocholine O-acyltransferase

2.3.1.63 1-alkylglycerophosphocholine O-acyltransferase

2.3.1.64 agmatine N⁴-coumaroyltransferase

2.3.1.65 bile acid-CoA:amino acid N-acyltransferase

2.3.1.66 leucine N-acetyltransferase

2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase

2.3.1.68 glutamine N-acyltransferase

2.3.1.69 monoterpenol O-acetyltransferase

2.3.1.70 CDP-acylglycerol O-arachidonoyltransferase

2.3.1.71 glycine N-benzoyltransferase

2.3.1.72 indoleacetylglucose—inositol O-acyltransferase

2.3.1.73 diacylglycerol—sterol O-acyltransferase

2.3.1.74 chalcone synthase

2.3.1.75 long-chain-alcohol O-fatty-acyltransferase

2.3.1.76 retinol O-fatty-acyltransferase

2.3.1.77 triacylglycerol—sterol O-acyltransferase

2.3.1.78 heparan-α-glucosaminide N-acetyltransferase

2.3.1.79 maltose O-acetyltransferase

2.3.1.80 cysteine-S-conjugate N-acetyltransferase

2.3.1.81 aminoglycoside 3-N-acetyltransferase

2.3.1.82 aminoglycoside 6′-N-acetyltransferase

2.3.1.83 phosphatidylcholine—dolichol O-acyltransferase

2.3.1.84 alcohol O-acetyltransferase

2.3.1.85 fatty-acid synthase system

2.3.1.86 fatty-acyl-CoA synthase system

2.3.1.87 aralkylamine N-acetyltransferase

2.3.1.88 peptide α-N-acetyltransferase

2.3.1.89 tetrahydrodipicolinate N-acetyltransferase

2.3.1.90 β-glucogallin O-galloyltransferase

2.3.1.91 sinapoylglucose—choline O-sinapoyltransferase

2.3.1.92 sinapoylglucose—malate O-sinapoyltransferase

2.3.1.93 13-hydroxylupanine O-tigloyltransferase

2.3.1.94 6-deoxyerythronolide-B synthase

2.3.1.95 trihydroxystilbene synthase

2.3.1.96 glycoprotein N-palmitoyltransferase

2.3.1.97 glycylpeptide N-tetradecanoyltransferase

2.3.1.98 chlorogenate—glucarate O-hydroxycinnamoyltransferase

2.3.1.99 quinate O-hydroxycinnamoyltransferase

2.3.1.100 [myelin-proteolipid] O-palmitoyltransferase

2.3.1.101 formylmethanofuran—tetrahydromethanopterin N-formyltransferase

2.3.1.102 N⁶-hydroxylysine N-acetyltransferase

2.3.1.103 sinapoylglucose—sinapoylglucose O-sinapoyltransferase

2.3.1.104 1-alkenylglycerophosphocholine O-acyltransferase

2.3.1.105 alkylglycerophosphate 2-O-acetyltransferase

2.3.1.106 tartronate O-hydroxycinnamoyltransferase

2.3.1.107 deacetylvindoline O-acetyltransferase

2.3.1.108 α-tubulin N-acetyltransferase

2.3.1.109 arginine N-succinyltransferase

2.3.1.110 tyramine N-feruloyltransferase

2.3.1.111 mycocerosate synthase

2.3.1.112 D-tryptophan N-malonyltransferase

2.3.1.113 anthranilate N-malonyltransferase

2.3.1.114 3,4-dichloroaniline N-malonyltransferase

2.3.1.115 isoflavone-7-O-β-glucoside 6′′-O-malonyltransferase

2.3.1.116 flavonol-3-O-β-glucoside O-malonyltransferase

2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

2.3.1.118 N-hydroxyarylamine O-acetyltransferase

2.3.1.119 icosanoyl-CoA synthase

2.3.1.120 created 1990, deleted 1992

2.3.1.121 1-alkenylglycerophosphoethanolamine O-acyltransferase

2.3.1.122 trehalose O-mycolyltransferase

2.3.1.123 dolichol O-acyltransferase

2.3.1.124 created 1990, deleted 1992

2.3.1.125 1-alkyl-2-acetylglycerol O-acyltransferase

2.3.1.126 isocitrate O-dihydroxycinnamoyltransferase

2.3.1.127 ornithine N-benzoyltransferase

2.3.1.128 ribosomal-protein-alanine N-acetyltransferase

2.3.1.129 acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase

2.3.1.130 galactarate O-hydroxycinnamoyltransferase

2.3.1.131 glucarate O-hydroxycinnamoyltransferase

2.3.1.132 glucarolactone O-hydroxycinnamoyltransferase

2.3.1.133 shikimate O-hydroxycinnamoyltransferase

2.3.1.134 galactolipid O-acyltransferase

2.3.1.135 phosphatidylcholine—retinol O-acyltransferase

2.3.1.136 polysialic-acid O-acetyltransferase

2.3.1.137 carnitine O-octanoyltransferase

2.3.1.138 putrescine N-hydroxycinnamoyltransferase

2.3.1.139 ecdysone O-acyltransferase

2.3.1.140 rosmarinate synthase

2.3.1.141 galactosylacylglycerol O-acyltransferase

2.3.1.142 glycoprotein O-fatty-acyltransferase

2.3.1.143 β-glucogallin—tetrakisgalloylglucose O-galloyltransferase

2.3.1.144 anthranilate N-benzoyltransferase

2.3.1.145 piperidine N-piperoyltransferase

2.3.1.146 pinosylvin synthase

2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent)

2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent)

2.3.1.149 platelet-activating factor acetyltransferase

2.3.1.150 salutaridinol 7-O-acetyltransferase

2.3.1.151 2,3′,4,6-tetrahydroxybenzophenone synthase

2.3.1.152 alcohol O-cinnamoyltransferase

2.3.1.153 anthocyanin 5-(6′′′-hydroxycinnamoyltransferase)

2.3.1.154 propionyl-CoA C²-trimethyltridecanoyltransferase

2.3.1.155 acetyl-CoA C-myristoyltransferase

2.3.1.156 phloroisovalerophenone synthase

2.3.1.157 glucosamine-1-phosphate N-acetyltransferase

2.3.1.158 phospholipid:diacylglycerol acyltransferase

2.3.1.159 acridone synthase

2.3.1.160 vinorine synthase

2.3.1.161 lovastatin nonaketide synthase

2.3.1.162 taxadien-5α-ol O-acetyltransferase

2.3.1.163 10-hydroxytaxane O-acetyltransferase

2.3.1.164 isopenicillin-N N-acyltransferase

2.3.1.165 6-methylsalicylic-acid synthase

2.3.1.166 2α-hydroxytaxane 2-O-benzoyltransferase

2.3.1.167 10-deacetylbaccatin III 10-O-acetyltransferase

2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

2.3.1.169 CO-methylating acetyl-CoA synthase

2.3.1.170 6′-deoxychalcone synthase

2.3.1.171 anthocyanin 6′′-O-malonyltransferase

2.3.1.172 anthocyanin 5-O-glucoside 6′′′-O-malonyltransferase

2.3.1.173 flavonol-3-O-triglucoside O-coumaroyltransferase

2.3.1.174 3-oxoadipyl-CoA thiolase

2.3.1.175 deacetylcephalosporin-C acetyltransferase

2.3.1.176 propanoyl-CoA C-acyltransferase

2.3.1.177 3,5-dihydroxybiphenyl synthase

2.3.1.178 diaminobutyrate acetyltransferase

2.3.1.179 β-ketoacyl-[acyl-carrier-protein] synthase II

2.3.1.180 β-ketoacyl-[acyl-carrier-protein] synthase III

2.3.1.181 lipoyl(octanoyl) transferase

2.3.1.182 (R)-citramalate synthase

2.3.1.183 phosphinothricin acetyltransferase

2.3.1.184 acyl-homoserine-lactone synthase

2.3.1.185 tropine acyltransferase

2.3.1.186 pseudotropine acyltransferase

2.3.1.187 acetyl-S-ACP:malonate ACP transferase

2.3.1.188 ω-hydroxypalmitate O-feruloyl transferase

2.3.1.189 mycothiol synthase

2.3.1.190 acetoin dehydrogenase system

2.3.1.191 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase

2.3.1.192 glycine N-phenylacetyltransferase

2.3.1.193 tRNA^Met cytidine acetyltransferase

2.3.1.194 acetoacetyl-CoA synthase

2.3.1.195 (Z)-3-hexen-1-ol acetyltransferase

2.3.1.196 benzyl alcohol O-benzoyltransferase

2.3.1.197 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose 3-N-acetyltransferase

2.3.1.198 glycerol-3-phosphate 2-O-acyltransferase

2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

2.3.1.200 lipoyl amidotransferase

2.3.1.201 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase

2.3.1.202 UDP-4-amino-4,6-dideoxy-N-acetyl-β-L-altrosamine N-acetyltransferase

2.3.1.203 UDP-N-acetylbacillosamine N-acetyltransferase

2.3.1.204 octanoyl-[GcvH]:protein N-octanoyltransferase

2.3.1.205 fumigaclavine B O-acetyltransferase

2.3.1.206 3,5,7-trioxododecanoyl-CoA synthase

2.3.1.207 β-ketodecanoyl-[acyl-carrier-protein] synthase

2.3.1.208 4-hydroxycoumarin synthase

2.3.1.209 dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase

2.3.1.210 dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase

2.3.1.211 bisdemethoxycurcumin synthase

2.3.1.212 benzalacetone synthase

2.3.1.213 cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6′′′-O-hydroxycinnamoyltransferase

2.3.1.214 pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4′′′-malonyltransferase

2.3.1.215 anthocyanidin 3-O-glucoside 6′′-O-acyltransferase

2.3.1.216 5,7-dihydroxy-2-methylchromone synthase

2.3.1.217 curcumin synthase

2.3.1.218 phenylpropanoylacetyl-CoA synthase

2.3.1.219 demethoxycurcumin synthase

2.3.1.220 2,4,6-trihydroxybenzophenone synthase

2.3.1.221 noranthrone synthase

2.3.1.222 phosphate propanoyltransferase

2.3.1.223 3-oxo-5,6-didehydrosuberyl-CoA thiolase

2.3.1.224 acetyl-CoA-benzylalcohol acetyltransferase

2.3.1.225 protein S-acyltransferase

2.3.1.226 carboxymethylproline synthase

2.3.1.227 GDP-perosamine N-acetyltransferase

2.3.1.228 isovaleryl-homoserine lactone synthase

2.3.1.229 4-coumaroyl-homoserine lactone synthase

2.3.1.230 2-heptyl-4(1H)-quinolone synthase

2.3.1.231 tRNA^Phe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine³⁷-N}-methoxycarbonyltransferase

2.3.1.232 methanol O-anthraniloyltransferase

2.3.1.233 1,3,6,8-tetrahydroxynaphthalene synthase

2.3.1.234 N⁶-L-threonylcarbamoyladenine synthase

2.3.1.235 tetracenomycin F2 synthase

2.3.1.236 5-methylnaphthoic acid synthase

2.3.1.237 neocarzinostatin naphthoate synthase

2.3.1.238 monacolin J acid methylbutanoate transferase

2.3.1.239 10-deoxymethynolide synthase

2.3.1.240 narbonolide synthase

2.3.1.241 Kdo₂-lipid IV_A acyltransferase

2.3.1.242 Kdo₂-lipid IV_A palmitoleoyltransferase

2.3.1.243 acyl-Kdo₂-lipid IV_A acyltransferase

2.3.1.244 2-methylbutanoate polyketide synthase

2.3.1.245 3-hydroxy-5-phosphooxypentane-2,4-dione thiolase

2.3.1.246 3,5-dihydroxyphenylacetyl-CoA synthase

2.3.1.247 3-keto-5-aminohexanoate cleavage enzyme

2.3.1.248 spermidine disinapoyl transferase

2.3.1.249 spermidine dicoumaroyl transferase

2.3.1.250 [Wnt protein] O-palmitoleoyl transferase

2.3.1.251 lipid IV_A palmitoyltransferase

2.3.1.252 mycolipanoate synthase

2.3.1.253 phloroglucinol synthase

2.3.1.254 N-terminal methionine N^α-acetyltransferase NatB

2.3.1.255 N-terminal amino-acid N^α-acetyltransferase NatA

2.3.1.256 N-terminal methionine N^α-acetyltransferase NatC

2.3.1.257 N-terminal L-serine N^α-acetyltransferase NatD

2.3.1.258 N-terminal methionine N^α-acetyltransferase NatE

2.3.1.259 N-terminal methionine N^α-acetyltransferase NatF

2.3.1.260 tetracycline polyketide synthase

2.3.1.261 (4-hydroxyphenyl)alkanoate synthase

2.3.1.262 anthraniloyl-CoA anthraniloyltransferase

2.3.1.263 2-amino-4-oxopentanoate thiolase

2.3.1.264 β-lysine N⁶-acetyltransferase

2.3.1.265 phosphatidylinositol dimannoside acyltransferase

2.3.1.266 [ribosomal protein S18]-alanine N-acetyltransferase

2.3.1.267 [ribosomal protein S5]-alanine N-acetyltransferase

2.3.1.268 ethanol O-acetyltransferase

2.3.1.269 apolipoprotein N-acyltransferase

2.3.1.270 lyso-ornithine lipid O-acyltransferase

2.3.1.271 L-glutamate-5-semialdehyde N-acetyltransferase

2.3.1.272 2-acetylphloroglucinol acetyltransferase

2.3.1.273 diglucosylglycerate octanoyltransferase

2.3.1.274 phosphate acyltransferase

2.3.1.275 acyl phosphate:glycerol-3-phosphate acyltransferase

2.3.1.276 galactosamine-1-phosphate N-acetyltransferase

2.3.1.277 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase

2.3.1.278 mycolipenoyl-CoA—2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase

2.3.1.279 long-chain-acyl-CoA—trehalose acyltransferase

2.3.1.280 (aminoalkyl)phosphonate N-acetyltransferase

2.3.1.281 5-hydroxydodecatetraenal polyketide synthase

2.3.1.282 phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase

2.3.1.283 2′-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

2.3.1.284 3′-(hydroxy)phthioceranyl-2′-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

2.3.1.285 (13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase

2.3.1.286 protein acetyllysine N-acetyltransferase

2.3.1.287 phthioceranic/hydroxyphthioceranic acid synthase

2.3.1.288 2-O-sulfo trehalose long-chain-acyltransferase

2.3.1.289 aureothin polyketide synthase system

2.3.1.290 spectinabilin polyketide synthase system

2.3.1.291 sphingoid base N-palmitoyltransferase

2.3.1.292 (phenol)carboxyphthiodiolenone synthase

2.3.1.293 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

2.3.1.294 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II

2.3.1.295 mycoketide-CoA synthase

2.3.1.296 ω-hydroxyceramide transacylase

2.3.1.297 very-long-chain ceramide synthase

2.3.1.298 ultra-long-chain ceramide synthase

2.3.1.299 sphingoid base N-stearoyltransferase

2.3.1.300 branched-chain β-ketoacyl-[acyl-carrier-protein] synthase

2.3.1.301 mycobacterial β-ketoacyl-[acyl carrier protein] synthase III

2.3.1.302 hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase

2.3.1.303 α-L-Rha-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Gal-PP-Und 2^IV-O-acetyltransferase

2.3.1.304 poly[(R)-3-hydroxyalkanoate] polymerase

2.3.1.305 acyl-[acyl-carrier protein]—UDP-2-acetamido-3-amino-2,3-dideoxy-α-D-glucopyranose N-acyltransferase

2.3.1.306 acetyl-CoA:lysine N⁶-acetyltransferase

2.3.1.307 6-diazo-5-oxo-L-norleucine N^α-acetyltranferase

2.3.1.308 tubulin N-terminal N-acetyltransferase NAT9

2.3.1.309 [β-tubulin]-L-lysine N-acetyltransferase

2.3.1.310 benzoylsuccinyl-CoA thiolase

2.3.2 Aminoacyltransferases

2.3.3 Acyl groups converted into alkyl groups on transfer

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)