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EC 2.3.1.184 Details
EC number
2.3.1.184
Accepted name
acyl-homoserine-lactone synthase
Reaction
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5′-thioadenosine + an N-acyl-L-homoserine lactone
Other name(s)
acyl-homoserine lactone synthase,
acyl homoserine lactone synthase,
acyl-homoserinelactone synthase,
acylhomoserine lactone synthase,
AHL synthase,
AHS,
AHSL synthase,
AhyI,
AinS,
AinS protein,
autoinducer synthase,
autoinducer synthesis protein rhlI,
EsaI,
ExpISCC1; ExpISCC3065,
LasI,
LasR,
LuxI,
LuxI protein,
LuxM,
N-acyl homoserine lactone synthase,
RhlI,
YspI ,
acyl-[acyl carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Systematic name
acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
CAS registry number
176023-66-8
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1].
History
created 2007
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992