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EC 2.3.1.193 Details
EC number
2.3.1.193
Accepted name
tRNAMet cytidine acetyltransferase
Reaction
[elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA + H2O = CoA + [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate
Other name(s)
YpfI, TmcA
Systematic name
acetyl-CoA:[elongator tRNAMet]-cytidine34 N4-acetyltransferase (ATP-hydrolysing)
Comment
The enzyme acetylates the wobble base cytidine34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine [1].
History
created 2011
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992