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EC 2.3.1.135 Details
EC number
2.3.1.135
Accepted name
phosphatidylcholine—retinol O-acyltransferase
Reaction
phosphatidylcholine + retinol—[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester—[cellular-retinol-binding-protein]
Other name(s)
lecithin—retinol acyltransferase,
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase,
lecithin:retinol acyltransferase,
lecithin-retinol acyltransferase,
retinyl ester synthase,
LRAT,
lecithin retinol acyl transferase
Systematic name
phosphatidylcholine:retinol—[cellular-retinol-binding-protein] O-acyltransferase
CAS registry number
117444-03-8
Comment
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
History
created 1992, modified 2011
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992