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EC 2.3.1.176 Details
EC number
2.3.1.176
Accepted name
propanoyl-CoA C-acyltransferase
Reaction
3α,7α,12α-trihydroxy-5β-cholanoyl-CoA + propanoyl-CoA = CoA + 3α,7α,12α-trihydroxy-24-oxo-5β-cholestanoyl-CoA
Other name(s)
SCP2 (gene name),
peroxisomal thiolase 2,
sterol carrier protein-χ,
SCPχ,
PTE-2 (ambiguous),
propionyl-CoA C2-trimethyltridecanoyltransferase,
3-oxopristanoyl-CoA hydrolase,
3-oxopristanoyl-CoA thiolase,
peroxisome sterol carrier protein thiolase,
sterol carrier protein,
oxopristanoyl-CoA thiolase,
peroxisomal 3-oxoacyl coenzyme A thiolase,
SCPx,
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Systematic name
3α,7α,12α-trihydroxy-5β-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Comment
Also acts on dihydroxy-5β-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R′) by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3].
History
created 2005 (EC 2.3.1.154 created 2000, incorporated 2015)
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992